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Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy
- Chinese Journal of Integrative Medicine Vol. 19, Issue 1, Pages: 73-79(2013)
- Affiliations：
1. Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran,Iran
2. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran,Iran
- Author bio：
- Funds：
DOI：10.1007/s11655-013-1327-0
CLC：Published：2013，
Published Online：29 December 2012，
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Rahimi, R., Ardekani, M.R.S. Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy., Chin. J. Integr. Med. 19, 73–79 (2013). https://doi.org/10.1007/s11655-013-1327-0
Roja Rahimi, Mohammad Reza Shams Ardekani. Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. [J]. Chinese Journal of Integrative Medicine 19(1):73-79(2013)
Rahimi, R., Ardekani, M.R.S. Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy., Chin. J. Integr. Med. 19, 73–79 (2013). https://doi.org/10.1007/s11655-013-1327-0 DOI：
Roja Rahimi, Mohammad Reza Shams Ardekani. Medicinal properties of Foeniculum vulgare Mill. in traditional Iranian medicine and modern phytotherapy. [J]. Chinese Journal of Integrative Medicine 19(1):73-79(2013) DOI： 10.1007/s11655-013-1327-0.
摘要
Foeniculum vulgare Mill. (F. vulgare)
commonly known as Fennel
is a popular medicinal plant with various pharmacological activities mentioned in traditional Iranian medicine (TIM) and modern phytotherapy such as antioxidant
cytotoxic
anti-inflammatory
antimicrobial
bronchodilatory
estrogenic
diuretic
lithontripic
galactogogue
emmenagogue
antithrombotic
hypotensive
gastroprotective
hepatoprotective
memory enhancing
and antimutagenic activities. No serious adverse events were recorded after ingestion of F. vulgare except some cases of allergic reactions. The estrogenic activity of F. vulgare brings some side effects such as decrease in protein concentration and acid and alkaline phosphatase in male genital organs
increase in weight of mammary glands and reproductive organs in women and premature thelarche in girls. However
no evidence of teratogenicity was recorded
it is better not to use F. vulgare during pregnancy due to its estrogenic activity. Because of inhibition of cytochrome P450 3A4 (CYP3A4)
the pharmacokinetic parameters of drugs mainly metabolized by this isozyme may be affected by F. vulgare. In addition
a significant interaction between cyprofloxacin and F. vulgare was demonstrated. The aim of current paper is to review pharmacological properties
toxicity and adverse events
and drug interactions of vulgare and brings conclusive results about the use of this plant in men
women and during pregnancy.
Abstract
Foeniculum vulgare Mill. (F. vulgare)
commonly known as Fennel
is a popular medicinal plant with various pharmacological activities mentioned in traditional Iranian medicine (TIM) and modern phytotherapy such as antioxidant
cytotoxic
anti-inflammatory
antimicrobial
bronchodilatory
estrogenic
diuretic
lithontripic
galactogogue
emmenagogue
antithrombotic
hypotensive
gastroprotective
hepatoprotective
memory enhancing
and antimutagenic activities. No serious adverse events were recorded after ingestion of F. vulgare except some cases of allergic reactions. The estrogenic activity of F. vulgare brings some side effects such as decrease in protein concentration and acid and alkaline phosphatase in male genital organs
increase in weight of mammary glands and reproductive organs in women and premature thelarche in girls. However
no evidence of teratogenicity was recorded
it is better not to use F. vulgare during pregnancy due to its estrogenic activity. Because of inhibition of cytochrome P450 3A4 (CYP3A4)
the pharmacokinetic parameters of drugs mainly metabolized by this isozyme may be affected by F. vulgare. In addition
a significant interaction between cyprofloxacin and F. vulgare was demonstrated. The aim of current paper is to review pharmacological properties
toxicity and adverse events
and drug interactions of vulgare and brings conclusive results about the use of this plant in men
women and during pregnancy.
关键词
Foeniculum vulgare Mill.Fennelpharmacological activitytraditional Iranian medicinemodern phytotherapy
Keywords
Foeniculum vulgare Mill.Fennelpharmacological activitytraditional Iranian medicinemodern phytotherapy
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