FOLLOWUS
Blood stasis syndrome of coronary heart disease: A perspective of modern medicine
- Chinese Journal of Integrative Medicine Vol. 20, Issue 4, Pages: 300-306(2014)
- Affiliations：
Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. 81173116)
DOI：10.1007/s11655-013-1332-3
CLC：Published：2014，
Published Online：27 July 2013，
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Yu, G., Wang, J. Blood stasis syndrome of coronary heart disease: A perspective of modern medicine., Chin. J. Integr. Med. 20, 300–306 (2014). https://doi.org/10.1007/s11655-013-1332-3
Gui Yu, Jie Wang. Blood stasis syndrome of coronary heart disease: A perspective of modern medicine. [J]. Chinese Journal of Integrative Medicine 20(4):300-306(2014)
Yu, G., Wang, J. Blood stasis syndrome of coronary heart disease: A perspective of modern medicine., Chin. J. Integr. Med. 20, 300–306 (2014). https://doi.org/10.1007/s11655-013-1332-3 DOI：
Gui Yu, Jie Wang. Blood stasis syndrome of coronary heart disease: A perspective of modern medicine. [J]. Chinese Journal of Integrative Medicine 20(4):300-306(2014) DOI： 10.1007/s11655-013-1332-3.
摘要
The medical community as a whole is attempting to start preventive therapy for coronary heart disease (CHD) patients earlier in life. However
the main limitations of such interventions are drug resistance and adverse reactions. Additionally
traditional biomarker discovery methods for CHD focus on the behavior of individual biomarkers regardless of their relevance. These limitations have led to attempting novel approaches to multi-dimensionally investigate CHD and identify safe and efficacious therapies for preventing CHD. Recently
the benefit of Chinese medicine (CM) in CHD has been proven by increasing clinical evidence. More importantly
linking CM theory with modern biomedicine may lead to new scientific discoveries. According to CM theory
all treatments for patients should be based on patients’ syndromes. A recent epidemiological investigation has demonstrated that blood stasis syndrome (BSS) is the major syndrome type of CHD. BSS is a type of complex pathophysiological state characterized by decreased or impeded blood flow. Common clinical features of BSS include a darkish complexion
scaly dry skin
and cyanosis of the lips and nails
a purple or dark tongue with purple spots
a thready and hesitant pulse
and stabbing or pricking pain fixed in location accompanied by tenderness
mass formation and ecchymosis or petechiae. The severity of BSS is significantly correlated with the complexity of coronary lesions and the degree of stenosis
and is an important factor affecting the occurrence of restenosis after percutaneous coronary intervention. The mechanisms of BSS of CHD patients should be investigated from a modern medicine perspective. Although many studies have attempted to explore the biomedical mechanisms of BSS of CHD
from hemorheological disorders to inflammation and immune responses
the global picture of BSS of CHD is still unclear. In this article
the current status of studies investigating the biomedical mechanisms of BSS of CHD and future perspectives are discussed.
Abstract
The medical community as a whole is attempting to start preventive therapy for coronary heart disease (CHD) patients earlier in life. However
the main limitations of such interventions are drug resistance and adverse reactions. Additionally
traditional biomarker discovery methods for CHD focus on the behavior of individual biomarkers regardless of their relevance. These limitations have led to attempting novel approaches to multi-dimensionally investigate CHD and identify safe and efficacious therapies for preventing CHD. Recently
the benefit of Chinese medicine (CM) in CHD has been proven by increasing clinical evidence. More importantly
linking CM theory with modern biomedicine may lead to new scientific discoveries. According to CM theory
all treatments for patients should be based on patients’ syndromes. A recent epidemiological investigation has demonstrated that blood stasis syndrome (BSS) is the major syndrome type of CHD. BSS is a type of complex pathophysiological state characterized by decreased or impeded blood flow. Common clinical features of BSS include a darkish complexion
scaly dry skin
and cyanosis of the lips and nails
a purple or dark tongue with purple spots
a thready and hesitant pulse
and stabbing or pricking pain fixed in location accompanied by tenderness
mass formation and ecchymosis or petechiae. The severity of BSS is significantly correlated with the complexity of coronary lesions and the degree of stenosis
and is an important factor affecting the occurrence of restenosis after percutaneous coronary intervention. The mechanisms of BSS of CHD patients should be investigated from a modern medicine perspective. Although many studies have attempted to explore the biomedical mechanisms of BSS of CHD
from hemorheological disorders to inflammation and immune responses
the global picture of BSS of CHD is still unclear. In this article
the current status of studies investigating the biomedical mechanisms of BSS of CHD and future perspectives are discussed.
关键词
Blood Stasis Syndromecoronary heart diseaseModern Medicine
Keywords
Blood Stasis Syndromecoronary heart diseaseModern Medicine
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