Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis

Xin Deng; Jian Liang; Zhen-wei Liu; Fa-sheng Wu; Xuan Li

doi:10.1007/s11655-013-1433-7

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Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis

Updated：2021-08-27

- Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis
- Chinese Journal of Integrative Medicine Vol. 19, Issue 4, Pages: 289-296(2013)
- Affiliations：
  
  Ruikang Hospital of Guangxi University of Chinese Medical,Nanning,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81160433) and the Guangxi Natural Science Foundation (No. 2011GXNSFD018035 and GZKZZ1103)
- DOI：10.1007/s11655-013-1433-7
  CLC：
- Published：2013，
  
  Published Online：2 April 2013，
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Deng, X., Liang, J., Liu, Zw. et al. Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis., Chin. J. Integr. Med. 19, 289–296 (2013). https://doi.org/10.1007/s11655-013-1433-7

Xin Deng, Jian Liang, Zhen-wei Liu, et al. Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis. [J]. Chinese Journal of Integrative Medicine 19(4):289-296(2013)
Deng, X., Liang, J., Liu, Zw. et al. Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis., Chin. J. Integr. Med. 19, 289–296 (2013). https://doi.org/10.1007/s11655-013-1433-7 DOI：

Xin Deng, Jian Liang, Zhen-wei Liu, et al. Treatment of posthepatitic cirrhosis by Fuzheng Huayu Tablet (扶正化瘀片) for reinforcing qi and resolving stasis. [J]. Chinese Journal of Integrative Medicine 19(4):289-296(2013) DOI： 10.1007/s11655-013-1433-7.

摘要

To investigate the efficacy and safety of the Fuzheng Huayu Tablet (扶正化瘀片

FZHYT)

which is used to reinforce qi and resolve stasis in patients with posthepatitic cirrhosis (PHC). A multicenter

randomized

controlled clinical trial was conducted in 180 patients with PHC. The patients were randomly assigned using random numbers to a treatment group treated with FZHYT and a placebo group; the treatment course was 6 months for both groups. Overall response

adverse events (AEs)

and the 2-year survival rate were assessed after treatment. Evaluations were made on changes in liver function

liver fibrosis

coagulation

hemodynamics

degrees of esophagogastric varices

ascites

quality of life (QOL)

and scores of main symptoms. The overall response was significantly higher in the treatment group than the placebo group (86.7% vs. 62.2%

P<0.01). Patients in both groups had significant improvements in liver function [total bilirubin (TBIL)

albumin (ALB)]

liver fibrosis [hyaluronic acid (HA)

type IV collagen (CIV)]

coagulation [prothrombin time (PT)

activated partial thromboplastin time (APTT)

fibrinogen (FIB)

and thrombin time (TT)]

hemodynamics portal venous flow (PVF)

and splenic vein flow (SVF) after treatment. Between-group comparisons showed that compared with the placebo group patients in the treatment group achieved significantly greater improvements in TBIL

ALB

C IV

APTT

PVF

SVF

time to ascites resolution

2-year survival

QOL

and symptom scores (P<0.05 or P<0.01). There were no significant AEs during the treatment. FZHYT is effective and safe for the treatment of hepatic cirrhosis as it is associated with improved liver function

liver fibrosis

coagulation

portal hypertension state

QOL

2-year survival rate

and fewer AEs.

Abstract

To investigate the efficacy and safety of the Fuzheng Huayu Tablet (扶正化瘀片

FZHYT)

which is used to reinforce qi and resolve stasis in patients with posthepatitic cirrhosis (PHC). A multicenter

randomized

adverse events (AEs)

and the 2-year survival rate were assessed after treatment. Evaluations were made on changes in liver function

liver fibrosis

coagulation

hemodynamics

degrees of esophagogastric varices

ascites

quality of life (QOL)

and scores of main symptoms. The overall response was significantly higher in the treatment group than the placebo group (86.7% vs. 62.2%

P<0.01). Patients in both groups had significant improvements in liver function [total bilirubin (TBIL)

albumin (ALB)]

liver fibrosis [hyaluronic acid (HA)

type IV collagen (CIV)]

coagulation [prothrombin time (PT)

activated partial thromboplastin time (APTT)

fibrinogen (FIB)

and thrombin time (TT)]

hemodynamics portal venous flow (PVF)

and splenic vein flow (SVF) after treatment. Between-group comparisons showed that compared with the placebo group patients in the treatment group achieved significantly greater improvements in TBIL

ALB

C IV

APTT

PVF

SVF

time to ascites resolution

2-year survival

QOL

liver fibrosis

coagulation

portal hypertension state

QOL

2-year survival rate

and fewer AEs.

关键词

posthepatitic cirrhosisFuzheng Huayu Tabletblood-activatingstasis-resolvingclinical trial

Keywords

posthepatitic cirrhosisFuzheng Huayu Tabletblood-activatingstasis-resolvingclinical trial

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