Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats

Jue Song; Jun Li; Shi-rui Zheng; Yong Jin; Yan Huang

doi:10.1007/s11655-013-1442-6

Your Location：

Home >

Browse articles >

Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats

Updated：2021-08-27

- Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats
- Chinese Journal of Integrative Medicine Vol. 19, Issue 5, Pages: 353-359(2013)
- Affiliations：
  
  School of Pharmacy, Anhui Medical University,Hefei,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No.30973917) and Foundation of Provincial Key Laboratory of Anhui Medical University (No. SBSYS-0803)
- DOI：10.1007/s11655-013-1442-6
  CLC：
- Published：2013，
  
  Published Online：15 March 2013，
Scan for full text
Song, J., Li, J., Zheng, Sr. et al. Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats., Chin. J. Integr. Med. 19, 353–359 (2013). https://doi.org/10.1007/s11655-013-1442-6

Jue Song, Jun Li, Shi-rui Zheng, et al. Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats. [J]. Chinese Journal of Integrative Medicine 19(5):353-359(2013)
Song, J., Li, J., Zheng, Sr. et al. Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats., Chin. J. Integr. Med. 19, 353–359 (2013). https://doi.org/10.1007/s11655-013-1442-6 DOI：

Jue Song, Jun Li, Shi-rui Zheng, et al. Anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风) powder on chronic bronchitis rats. [J]. Chinese Journal of Integrative Medicine 19(5):353-359(2013) DOI： 10.1007/s11655-013-1442-6.

摘要

To investigate the anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风

YPF) Powder and its components in rats. A rat chronic bronchitis (CB) model was developed using lipopolysaccharide (LPS) combined with bacillus Calmette Guerin (BCG). YPF

simple recipe Astragalus membranaceus (Fisch.) Bge (AM) and Astragalus membranaceus (Fisch.) Bge plus rhizome of Atractylodes macrocephala Koidz (AM+RA) decoction were administered (intragastric administration

once a day for 21 days) to rats

to prevent and treat CB. Immunoregulatory and anti-inflammatory effects of YPF

AM and AM+RA were tested by serum pharmacology in vitro on splenic lymphocytes of normal rats and alveolar macrophages of CB rats. Inflammation in the pulmonary tissue and the bronchus of CB rats was significantly reduced in the YPF-treatment groups

AM and AM+RA groups demonstrating the efficacy of YPF. Serum samples collected at different times from rats after administration of YPF

AM and AM+RA demonstrated increased proliferation of splenic lymphocytes with area under the effect curve (AUE) of 552.6%

336.3% and 452.0%

respectively. Treatment of alveolar macrophages with serum samples in YPF

AM or AM+RA group inhibited interleukin-8 (IL-8) in the cell culture media

and the effect was much better in the YPF group compared with AM or AM+RA group

with a higher maximal effect (Emax

P<0.05) and larger AUE (P <0.01 and P<0.05). Moreover

serum from rats treated with AM or AM+RA had similar efficacy

while the efficiency was lower than that treated with YPF. YPF demonstrated anti-inflammatory and immunoregulatory effects in a rat model of CB

and timedependent relationships were demonstrated in vitro.

Abstract

To investigate the anti-inflammatory and immunoregulatory effects of Yupingfeng (玉屏风

YPF) Powder and its components in rats. A rat chronic bronchitis (CB) model was developed using lipopolysaccharide (LPS) combined with bacillus Calmette Guerin (BCG). YPF

once a day for 21 days) to rats

to prevent and treat CB. Immunoregulatory and anti-inflammatory effects of YPF

AM and AM+RA groups demonstrating the efficacy of YPF. Serum samples collected at different times from rats after administration of YPF

AM and AM+RA demonstrated increased proliferation of splenic lymphocytes with area under the effect curve (AUE) of 552.6%

336.3% and 452.0%

respectively. Treatment of alveolar macrophages with serum samples in YPF

AM or AM+RA group inhibited interleukin-8 (IL-8) in the cell culture media

and the effect was much better in the YPF group compared with AM or AM+RA group

with a higher maximal effect (Emax

P<0.05) and larger AUE (P <0.01 and P<0.05). Moreover

serum from rats treated with AM or AM+RA had similar efficacy

while the efficiency was lower than that treated with YPF. YPF demonstrated anti-inflammatory and immunoregulatory effects in a rat model of CB

and timedependent relationships were demonstrated in vitro.

关键词

Chinese MedicinepharmacodynamicsYupingfenganti-inflammatoryimmunoregulatory

Keywords

Chinese MedicinepharmacodynamicsYupingfenganti-inflammatoryimmunoregulatory

references

Wang SJ, Jiao CY, Sun XD. Clinical observation of effect of jiawei yupingfeng mixture for prevention and treatment of 100 children with repeated respiratory tract infection. Chin J Integr Tradit West Med (Chin) 2009;29:742–745.

Makino T. Pharmacological properties of Gyokuheifusan, a traditional Kampo medicinal formula. Yakugaku Zasshi 2005;125:349–354.

Makino T, Ito Y, Sasaki SY, Fujimura Y, Kano Y. Preventive and curative effects of Gyokuheifu-san, a formula of traditional Chinese medicine, on allergic rhinitis induced with Japanese cedar pollens in guinea pig. Biol Pharm Bull 2004;27:554–558.

Makino T, Sasaki SY, Ito Y, Kano Y. Pharmacological properties of raditional medicine: effects of gyokuheifusan on murine antigen-specific antibody production. Biol Pharm Bull 2005;28:110–113.

Gao J, Li J, Shao X, Jin Y, Lu XW, Ge JF, et al. Antiinflammatory and immunoregulatory effects of total glucosides of Yupingfeng powder. Chin Med J 2009;122:1636–1641.

Fang SP, Tanaka T, Tago F, Okamoto T, Kojima S. Immunomodulatory effects of gyokuheifusan on INFgamma/ IL-4 (Th1/Th2) balance in ovalbumin (OVA)-induced asthma model mice. Biol Pharm Bull 2005;28:829–833.

Jin ZF, Wang C, ed. Yu Ping Feng Powder. Beijing: Chin Med Sci Press; 2009:4–12.

Chinese Pharmacopoeia Commission ed. The Chinese Pharmacopoeia I. Beijing: Chemical Industry Press; 2005:409.

Huang Y, Li J, Meng XM, Jiang GL, Li H, Cao Q, et al. Effect of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. leaf and MAPK signal transduction pathway on inducible nitric oxide synthase expression in alveolar macrophage of chronic bronchitis rats. Am J Chin Med 2009;37:1099–1111.

Ge JF, Li J, Lu XW, Jin Y, Yao HW, Zhang L, et al. Establishment of chronic bronchitis rat model by combined utilization of Bacillus Calmette-Guerin (BCG) and lipopolysaccharide (LPS). Chin Pharm Bull (Chin) 2004;7:830–834.

Denizit F, Lang R. Rapid colorimetric assay for cell growth and survival. J Immunol Methods 1986;89:271–277.

Song J, Lu T, Xie L, Liu XD. A serum pharmacological study on antioxidation effects of Huanglian Jiedu Decoction. Chin J Exp Tradit Med Form (Chin) 2010;16:118–122.

Zeng ZP, Jiang JG. Analysis of the adverse reactions induced by natural product-derived drugs. Br J Pharmacol 2010;159:1374–1391.

Iwama H, Amagaya S, Ogihara Y. Effect of Shosaikoto, a Japanese and Chinese herbal medicinal mixture, on the mitogentic activity of Lipopolysaccharide; a new pharmacological testing method. J Ethmopharmacol 1987;21:45–53.

Bochu W, Liancai Z, Qi C. Primary study on the application of serum pharmacology in Chinese traditional medicine. Colloids Surf B Biointerfaces 2005;43:194–197.

Umeda M, Amagaya S, Ogihara Y. Effect of certain herbal medicines on the biotransformation of arachidonic acid. A new pharmacological testing method using serum. J Ethmopharmacol 1988;23:91–98.

FULL TEXT LINK

More>

Views

989

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Protective effects of Xiongshao Capsule (芎芍胶囊) on anti-inflammatory function of high-density lipoprotein in an atherosclerosis rabbit model

Review of Anemone raddeana Rhizome and its pharmacological effects

Future view and development of immunology: Exploring the immunology based on Chinese medicine and culture

Cost-effectiveness analysis of combined Chinese medicine and Western medicine for ischemic stroke patients

Objective tongue inspection on 142 liver cancer patients with damp-heat syndrome

Related Author

No data

Related Institution

Department of Emergency, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Department of General Medicine, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Administration Office, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Medical College, Hangzhou Normal University

Suzhou Dongrui Pharmaceutical Co., Ltd.

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰