Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial

Jie Wang; Yong Li; Yan-li Tang; Hong-sheng Lin; Xin-fang Wu; Jie Liu

doi:10.1007/s11655-013-1449-z

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Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial

Updated：2021-08-27

- Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial
- Chinese Journal of Integrative Medicine Vol. 19, Issue 5, Pages: 340-346(2013)
- Affiliations：
  
  Guang’anmen Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by Chinese Ministry of Science and Technology (No. 2008ZX10005-004)
- DOI：10.1007/s11655-013-1449-z
  CLC：
- Published：2013，
  
  Published Online：15 March 2013，
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Wang, J., Li, Y., Tang, Yl. et al. Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial., Chin. J. Integr. Med. 19, 340–346 (2013). https://doi.org/10.1007/s11655-013-1449-z

Jie Wang, Yong Li, Yan-li Tang, et al. Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 19(5):340-346(2013)
Wang, J., Li, Y., Tang, Yl. et al. Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial., Chin. J. Integr. Med. 19, 340–346 (2013). https://doi.org/10.1007/s11655-013-1449-z DOI：

Jie Wang, Yong Li, Yan-li Tang, et al. Effect of Immune No. 2 (免疫2号方) on the immune reconstitution in patients with HIV/AIDS after highly active antiretroviral treatment: A randomized double blind placebo controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 19(5):340-346(2013) DOI： 10.1007/s11655-013-1449-z.

摘要

To observe the Immune No. 2 (免疫2号方) on the immune reconstitution in patients with human immunodeficiency virus or acquired immune deficiency syndrome (HIV/AIDS) after highly active antiretroviral therapy (HAART). A randomized

double-blind

placebo-controlled clinical trial was designed. 233 patients failing immune reconstitution after HAART were randomly divided into treatment group (116 cases) and control group (117 cases)

respectively using Immune No. 2 plus HAART and placebo combined with HAART for 6 months. CD4

CD45RA

CD45RO cell numbers

as well as the symptoms

signs and integral improvement rates were observed in order to evaluate the immune reconstitution efficiency. after the intervention for 1 month

the effective rate of the treatment group (18.97%

22/116) was significantly higher than that of the control group (9.40%

11/117) (P=0.02); 3 months after treatment

the effective rate of the treatment group (27.59%

32/116) was no difference from that of the control group (22.22%

26/117) (P=0.31); 6 months after treatment

the effective rate of the treatment group (34.48%

40/116) was significantly superior to the control group (21.37%

25/117) (P=0.02). CD4

CD45RA

CD45RO count of the treatment group was significantly higher than that of the control group (P<0.05). The total score of symptoms and signs in the treatment group was significantly lowered compared with the control group (P=0.02)

and the improvement of fatigue

muscle and joint pain

pruritus and shortness of breath in the treatment group was better than the control group (P<0.05). Immune No. 2 can effectively improve the numbers of CD4 cells and its subgroups

as well as the main clinical symptoms and signs of patients after HAART

thereby promoting the immune reconstitution.

Abstract

double-blind

placebo-controlled clinical trial was designed. 233 patients failing immune reconstitution after HAART were randomly divided into treatment group (116 cases) and control group (117 cases)

respectively using Immune No. 2 plus HAART and placebo combined with HAART for 6 months. CD4

CD45RA

CD45RO cell numbers

as well as the symptoms

signs and integral improvement rates were observed in order to evaluate the immune reconstitution efficiency. after the intervention for 1 month

the effective rate of the treatment group (18.97%

22/116) was significantly higher than that of the control group (9.40%

11/117) (P=0.02); 3 months after treatment

the effective rate of the treatment group (27.59%

32/116) was no difference from that of the control group (22.22%

26/117) (P=0.31); 6 months after treatment

the effective rate of the treatment group (34.48%

40/116) was significantly superior to the control group (21.37%

25/117) (P=0.02). CD4

CD45RA

and the improvement of fatigue

muscle and joint pain

pruritus and shortness of breath in the treatment group was better than the control group (P<0.05). Immune No. 2 can effectively improve the numbers of CD4 cells and its subgroups

as well as the main clinical symptoms and signs of patients after HAART

thereby promoting the immune reconstitution.

关键词

HIV/AIDSimmune reconstitutionImmune No. 2

Keywords

HIV/AIDSimmune reconstitutionImmune No. 2

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