Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.

Xiao-xin Zhu; Yu-jie Li; Lan Yang; Dong Zhang; Ying Chen; Eva Kmonickova; Xiao-gang Weng; Qing Yang; Zdeněk Zídek

doi:10.1007/s11655-013-1460-4

Your Location：

Home >

Browse articles >

Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.

Updated：2021-08-27

- Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.
- Chinese Journal of Integrative Medicine Vol. 19, Issue 10, Pages: 761-770(2013)
- Affiliations：
  
  1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing,China
  2. Department of Pharmacology, Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
  3. Institute of Pharmacology and Toxicology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic
- Author bio：
- Funds：
  
  Supported by the International Science and Technology Cooperation Program of the People’s Republic of China (No. 2011DFA30870), and by the bilateral grant from the Ministry of Education, Youth and Sports of the Czech Republic (No. ME10116).
- DOI：10.1007/s11655-013-1460-4
  CLC：
- Published：2013，
  
  Published Online：5 August 2013，
Scan for full text
Zhu, Xx., Li, Yj., Yang, L. et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.., Chin. J. Integr. Med. 19, 761–770 (2013). https://doi.org/10.1007/s11655-013-1460-4

Xiao-xin Zhu, Yu-jie Li, Lan Yang, et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.. [J]. Chinese Journal of Integrative Medicine 19(10):761-770(2013)
Zhu, Xx., Li, Yj., Yang, L. et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.., Chin. J. Integr. Med. 19, 761–770 (2013). https://doi.org/10.1007/s11655-013-1460-4 DOI：

Xiao-xin Zhu, Yu-jie Li, Lan Yang, et al. Divergent immunomodulatory effects of extracts and phenolic compounds from the fern Osmunda japonica Thunb.. [J]. Chinese Journal of Integrative Medicine 19(10):761-770(2013) DOI： 10.1007/s11655-013-1460-4.

摘要

To study possible immunobiological potential of Osmunda japonica Thunb. Immunomodulatory effects of ethanol extracts prepared from rhizomes of O. japonica and phenolic compounds isolated from the extracts were investigated under the in vitro conditions using the rat peritoneal cells (2×106/mL; 24 h culture). Biosynthesis of nitric oxide (NO) was assayed by Griess reagent

production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. The extracts activated dose dependently

with the onset at 2.5–5 μmol/L concentrations

the high output NO production

and secretion of interferon-γ (IFN-γ)

tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3

4-hydroxybenzaldehyde. In contrasts

the acetone-type phenolics 4-hydroxybenzalacetone and 3

4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α

IL-1β

IL-6)

and PGE2. The 3

4-hydroxybenzalacetone was more effective than 4-hydroxybenzaldehyde. The IC50s estimates ranged within the interval of 5–10 μmol/L. No signs of cytotoxicity were observed up to the 50 μmol/L concentration of the compounds. Phenolic compounds contained in medicinal herb Osmunda japonica possess distinct immunomodulatory activity.

Abstract

production of prostaglandin E2 (PGE2) and secretion of cytokines were determined by enzyme-linked immunoabsorbent assay. The extracts activated dose dependently

with the onset at 2.5–5 μmol/L concentrations

the high output NO production

and secretion of interferon-γ (IFN-γ)

tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Mild enhancement of NO was produced by the aldehyde-type phenolics 4-hydroxybenzaldehyde and 3

4-hydroxybenzaldehyde. In contrasts

the acetone-type phenolics 4-hydroxybenzalacetone and 3

4-hydroxybenzalacetone inhibited production of immune mediators including cytokines (TNF-α

IL-1β

IL-6)

and PGE2. The 3

关键词

Osmunda japonica L.extractsphenolic compoundscytokinesNitric Oxideprostaglandin E2

Keywords

Osmunda japonica L.extractsphenolic compoundscytokinesNitric Oxideprostaglandin E2

references

Cai SQ, Li J, eds. Species systematization and quality evaluation of commonly used Chinese traditional drugs: North-China Edition II, 10:66. In Lou Z (ed): Beijing: Beijing Medical University Press; 1995:1236.

Woo ER, Kim HJ, Kwak JH, Lim YK, Park SK, Kim HS, et al. Anti-herpetic activity of various medicinal plant extracts. Arch Pharm Res 1997;20:58–67.

Zhao ZL, Leng CH, Wang ZT. Identification of Dryopteris crassirhizoma and the adulterant species based on cpDNA rbcL and translated amino acid sequences. Planta Med 2007;73:1230–1233.

Zhang ZH, He YF. Primary study on bacteriostatic activities of extracts from Osmunda japonica Thunb. Natural Sci E 2008;30:95–98.

Numata A, Takahashi C, Fujiki R, Kitano E, Kitajima A, Takemura T. Plant constituents biologically active to insects. VI. Antifeedants for larvae of the yellow butterfly, Eurema hecabe mandarina, in Osmunda japonica. (2). Chem Pharm Bull 1990;38:2862–2865.

Yu YM, Yang JS, Peng CZ, Caer V, Cong PZ, Zou ZM, et al. Lactones from Angiopteris caudatiformis. J Nat Prod 2009;72:921–924.

Watanabe K, Hayashi H, Mori Y. Effect of a benzylidene derivative, a novel antirheumatic agent, on IL-1 production. Pharmacol Res 1993;28:59–72.

Su BN, Jones WP, Cuendet M, Kardono LB, Ismail R, Riswan S, et al. Constituents of the stems of Macrococculus pomiferus and their inhibitory activities against cyclooxygenases-1 and -2. Phytochemistry 2004;65:2861–2866.

Lee JY, Jang YW, Kang HS, Moon H, Sim SS, Kim CJ. Anti-inflammatory action of phenolic compounds from Gastrodia elata root. Arch Pharm Res 2006;29:849–858.

Morikawa T, Ando S, Matsuda H, Kataoka S, Muraoka O, Yoshikawa M. Inhibitors of nitric oxide production from the rhizomes of Alpinia galanga: structures of new 8–9′ linked neolignans and sesquineolignan. Chem Pharm Bull 2005;53:625–630.

Hsieh YH, Kuo PM, Chien SC, Shyur LF, Wang SY. Effects of Chamaecyparis formosensis Matasumura extractives on lipopolysaccharide-induced release of nitric oxide. Phytomedicine 2007;14:675–680.

Chang ZQ, Gebru E, Lee SP, Rhee MH, Kim JC, Cheng H, et al. In vitro antioxidant and anti-inflammatory activities of protocatechualdehyde isolated from Phellinus gilvus. J Nutr Sci Vitaminol (Tokyo) 2011;57:118–122.

Marletta MA, Yoon PS, Iyengar R, Leaf CD, Wishnok JS. Macrophage oxidation of L-arginine to nitrite and nitrate. Biochemistry 1988;27:8706–8711.

Zídek Z, Farghali H, Kmoníčková E.Intrinsic nitric oxide-stimulatory activity of lipoteichoic acids from different Grampositive bacteria. Nitric Oxide 2010;23:300–310.

Punzón C, Alcaide A, Fresno M. In vitro anti-inflammatory activity of Phlebodium decumanum. Modulation of tumor necrosis factor and soluble TNF receptors. Int Immunopharmacol 2003;3:1293–1299.

Jańczyk A, Garcia-Lopez MA, Fernandez-Peñas P, Alonso-Lebrero JL, Benedicto I, López-Cabrera M, et al. A Polypodium leucotomos extract inhibits solar-simulated radiation-induced TNF-alpha and iNOS expression, transcriptional activation and apoptosis. Exp Dermatol 2007;16:823–829.

Nogal-Ruiz JJ, Gómez-Barrio A, Escario JA, Martínez-Fernández AR. Modulation by Polypodium leucotomos extract of cytokine patterns in experimental trichomoniasis model. Parasite 2003;10:73–78.

Philips N, Conte J, Chen YJ, Natrajan P, Taw M, Keller T, et al. Beneficial regulation of matrixmetalloproteinases and their inhibitors, fibrillar collagens and transforming growth factor-beta by Polypodium leucotomos, directly or in dermal fibroblasts, ultraviolet radiated fibroblasts, and melanoma cells. Arch Dermatol Res 2009;301:487–495.

Wills PJ, Asha VV. Protective mechanism of Lygodium flexuosum extract in treating and preventing carbon tetrachloride induced hepatic fibrosis in rats. Chem Biol Interact 2007;165:76–85.

Wu MJ, Weng CY, Wang L, Lian TW. Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.). J Ethnopharmacol 2005;98:73–81.

Yang JH, Kondratyuk TP, Marler LE, Qiu X, Choi Y, Cao H, et al. Isolation and evaluation of kaempferol glycosides from the fern Neocheiropteris palmatopedata. Phytochemistry 2010;71:641–647.

Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production. J Immunol 1988;141:2407–2412.

Wildfeuer A, Heymer B, Schleifer KH, Haferkamp O. Investigations on the specificity of the Limulus test for the detection of endotoxin. Appl Microbiol 1974;28:867–871.

Wilson M, Moore J, Kieser JB. Identity of limulus amoebocyte lysate-active root surface materials from periodontally involved teeth. J Clin Periodontol 1986;13:743–747.

Takemoto T, Okuyama T, Jin H, Arai T, Kawahara M, Konno C, et al. Isolation of phytoecdysones from Japanese ferns. I. Chem Pharm Bull 1973;21:2336–2338.

Koyama K, Fuke F, Kimura J, Toru O. The constituents of Osmunda spp. (I). Shoyakugaku Zasshi 1978;32:126–128.

Okuyama T, Hosoyama K, Hiraga Y. The constituents of Osmunda spp. II. A new flavonol glycoside of Osmunda asiatica. Chem Pharm Bull 1978;26:3071–3074.

Okuyama T, Ohta Y, Shibata S. The constituents of Osmunda spp. III. Studies on the sporophyll of Osmunda japonica. Shoyakugaku Zasshi 1979;33:185–186.

Li BW, Zhang D, Yang L, Fu MH, Fang J. Determination of polysaccharides from rhizoma of Osmunda japonica. Chin J Exp Tradit Med Formulae (Chin) 2010;16:41–43.

Li BW, Zhang D, Liu WG, Yang L. Determination of tannins in rhizoma of Osmunda japonica. Chin J Inform Tradit Chin Med (Chin) 2010;17:45–46.

Liew FY, Li Y, Millot S. Tumor necrosis factor-alpha synergizes with IFN-gamma in mediating killing of Leishmania major through the induction of nitric oxide. J Immunol 1990;145:4306–4310.

Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Curr Opin Immunol 1991;3:65–70.

Karupiah G, Xie QW, Buller RML, Nathan C, Duarte C, MacMicking JD. Inhibition of viral replication by interferon-γ-induced nitric oxide synthase. Science 1993;261:1445–1448.

Croen KD. Evidence for an antiviral effect of nitric oxide. Inhibition of herpes simplex virus type 1 replication. J Clin Invest 1993;91:2446–2452.

James SL. Role of nitric oxide in parasitic infections. Microbiol Rev 1995;59:533–547.

Rao CV, Indranie C, Simi B, Manning PT, Connor JR, Reddy BS. Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor. Cancer Res 2002;62:165–170.

Murakami A, Ohigashi H. Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 2007;121:2357–2363.

Laszlo F, Whittle BJ, Moncada S. Time-dependent enhancement or inhibition of endotoxin-induced vascular injury in rat intestine by nitric oxide synthase inhibitors. Br J Pharmacol 1994;111:1309–1315.

Dudhgaonkar SP, Tandan SK, Kumar D, Raviprakash V, Kataria M. Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats. Inflammopharmacology 2007;15:188–195.

Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 2007;42:3–27.

FULL TEXT LINK

More>

Views

917

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Anti-Inflammatory mechanism of total glycosides of Acanthopanax Giraldii

Effect of Shengmai injection (生脉注射液) on diaphragmatic contractility in doxorubicin-treated rats

Metabolic regulatory and anti-oxidative effects of modified bushen huoxue decoction (补肾活血方) on experimental rabbit model of osteoarthritis

Effects and potential mechanisms of Danzhi Xiaoyao Pill (丹栀逍遥丸) on proliferation of MCF-7 human breast cancer cells in vitro

Related Author

No data

Related Institution

Shenzhen Buji People’s Hospital

Department of Pharmacy, the First Affiliated Hospital, Sun Yat-sen University

Institute of Clinical Pharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University

Department of Hematology, the Affiliated Hospital of Guiyang Medical College

Key Laboratory of Basic Pharmacology of Guizhou and Department of Pharmacology, Zunyi Medical College

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰