Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice

Hai-xia Li; Xin-yu Guo; Yan Xie; Ming-xiao Ge; Qi-long Yuan; De-wei Lin; Lu Xiong; Wei-min Deng; Jin-yu Zhang

doi:10.1007/s11655-013-1463-1

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Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice

Updated：2021-08-27

- Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice
- Chinese Journal of Integrative Medicine Vol. 19, Issue 10, Pages: 755-760(2013)
- Affiliations：
  
  Reproductive Medicine Center, Department of Obstetrics and Gynecology, General Hospital of Guangzhou Military Command, Liuhuaqiao Hospital,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1463-1
  CLC：
- Published：2013，
  
  Published Online：5 August 2013，
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Li, Hx., Guo, Xy., Xie, Y. et al. Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice., Chin. J. Integr. Med. 19, 755–760 (2013). https://doi.org/10.1007/s11655-013-1463-1

Hai-xia Li, Xin-yu Guo, Yan Xie, et al. Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice. [J]. Chinese Journal of Integrative Medicine 19(10):755-760(2013)
Li, Hx., Guo, Xy., Xie, Y. et al. Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice., Chin. J. Integr. Med. 19, 755–760 (2013). https://doi.org/10.1007/s11655-013-1463-1 DOI：

Hai-xia Li, Xin-yu Guo, Yan Xie, et al. Yiqixue Buganshen Recipe (益气血补肝肾方) regulates the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice. [J]. Chinese Journal of Integrative Medicine 19(10):755-760(2013) DOI： 10.1007/s11655-013-1463-1.

摘要

To observe the effect of Yiqixue Buganshen recipe(益气血补肝肾方

YBR) on the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice. A total of 180 mice were divided into three groups: model group

treatment group and control group. The treatment and model groups were intraperitoneally injected with gonadotropin-releasing hormone analogue for 7 days; pregnant mare serum gonadotropin was also injected on the 7th day. After 48 h

human chorionic gonadotropin was injected. The control group was injected with an equal volume of saline at the same time. From the start of the experiment

the treatment group was intragastrically administered Jinghouzengzhi Recipe(经后增殖方) and Cuhuangti Recipe(促黄体方). The model group and the control group were intragastrically administered an equal volume of saline. Real-time reverse transcription polymerase chain reaction and Western blotting were used to detect the mRNA and protein expression of integrin ανβ3 in mouse endometrium. Integrin ανβ3 was expressed in mouse endometrium in all groups. Integrin αββ3 expression increased gradually along with pregnancy

progressing from pregnant day (Pd) 1. Integrin ανβ3 expression significantly increased on Pd 4

then began to decrease on Pd 6. Integrin ανβ3 expression in the treatment group was higher than in the model group

and the difference was statistically significant (P <0.05). The difference between the treatment group and the control group was not statistically significant (P >0.05). YBR improves endometrial receptivity

and may play an important role in embryonic implantation.

Abstract

To observe the effect of Yiqixue Buganshen recipe(益气血补肝肾方

YBR) on the expression of integrin ανβ3 in the endometrium of controlled ovarian hyperstimulation mice. A total of 180 mice were divided into three groups: model group

human chorionic gonadotropin was injected. The control group was injected with an equal volume of saline at the same time. From the start of the experiment

progressing from pregnant day (Pd) 1. Integrin ανβ3 expression significantly increased on Pd 4

then began to decrease on Pd 6. Integrin ανβ3 expression in the treatment group was higher than in the model group

and may play an important role in embryonic implantation.

关键词

Yiqixue Buganshen Recipe(益气血补肝肾方 YBR)controlled ovarian hyperstimulationintegrin ανβ3endometrial receptivityChinese Medicine

Keywords

Yiqixue Buganshen Recipe(益气血补肝肾方 YBR)controlled ovarian hyperstimulationintegrin ανβ3endometrial receptivityChinese Medicine

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Reproductive Center, the Affiliated Hospital of Shandong, University of Traditional Chinese Medicine

Basic Medicine Research Institution, Shandong Academy of Medical Sciences

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The Key Laboratory of Geriatrics, Beijing Hospital and Beijing Institute of Geriatrics’ Ministry of Public Health

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