Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits

Xiao-xi Tian; Bo-liang Wang; Yi-zhan Cao; Yue-xia Zhong; Yan-yang Tu; Jian-bo Xiao; Qian-feng He; Li-na Zhai

doi:10.1007/s11655-013-1513-8

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Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits

Updated：2021-08-27

- Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits
- Chinese Journal of Integrative Medicine Vol. 21, Issue 3, Pages: 229-233(2015)
- Affiliations：
  
  Emergency Department, Tangdu Hospital, Fourth Military Medical University,Xi’an,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1513-8
  CLC：
- Published：2015，
  
  Published Online：19 October 2013，
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Tian, Xx., Wang, Bl., Cao, Yz. et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits., Chin. J. Integr. Med. 21, 229–233 (2015). https://doi.org/10.1007/s11655-013-1513-8

Xiao-xi Tian, Bo-liang Wang, Yi-zhan Cao, et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits. [J]. Chinese Journal of Integrative Medicine 21(3):229-233(2015)
Tian, Xx., Wang, Bl., Cao, Yz. et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits., Chin. J. Integr. Med. 21, 229–233 (2015). https://doi.org/10.1007/s11655-013-1513-8 DOI：

Xiao-xi Tian, Bo-liang Wang, Yi-zhan Cao, et al. Comparison of protective effects of safflor injection and extract of Ginkgo biloba on lung ischemia/reperfusion injury in rabbits. [J]. Chinese Journal of Integrative Medicine 21(3):229-233(2015) DOI： 10.1007/s11655-013-1513-8.

摘要

To observe the protective effects of safflor Injection (SI) and extract of Ginkgo biloba (EGB) on lung ischemia-reperfusion injury (LIRI) and investigate its mechanism. In vivo rabbit model of LIRI was reconstructed. Forty rabbits were randomly and equally divided into four groups: sham-operation group (sham group)

ischemia-reperfusion group (model group)

ischemia-reperfusion plus SI group (safflor group) and ischemia-reperfusion plus EGB injection group (EGB group). Malondialdehyde (MDA) content

superoxide dismutase (SOD) and xanthine oxidase (XO) activity in serum were measured. The wet/dry weight ratio (W/D) of the lung tissue and activity of myeloperoxidase (MPO) were also tested. Ultrastructure change of the lung tissue was observed by the electron microscope. The expression of intercellular adhesion molecule-1 (ICAM-1) was measured by immunohistochemistry (IHC). In the model group

MDA and XO increased and SOD decreased in serum compared with the sham group (P<0.01). The values of W/D

MPO and ICAM-1 of the model group were higher than those of the sham group (P<0.01)

but those of the safflor group and EGB group were significantly lower than those of the model group (P<0.01). The IHC demonstrated that ICAM-1 expression in lung tissue of the model group was significantly higher than those of the safflor group (P<0.01). Compared with safflor group

in the EGB group MDA

MPO decreased

SOD and ICAM-1 expression increased (P<0.05)

but the change of W/D was not statistically significant (P>0.05). SI and EGB may attenuate LIRI through antioxidation

inhibition of neutrophil aggregation and down-regulation of ICAM-1 expression. But EGB had more effect on the antioxidation

while SI did better on regulating ICAM-1 expression.

Abstract

ischemia-reperfusion group (model group)

ischemia-reperfusion plus SI group (safflor group) and ischemia-reperfusion plus EGB injection group (EGB group). Malondialdehyde (MDA) content

MDA and XO increased and SOD decreased in serum compared with the sham group (P<0.01). The values of W/D

MPO and ICAM-1 of the model group were higher than those of the sham group (P<0.01)

in the EGB group MDA

MPO decreased

SOD and ICAM-1 expression increased (P<0.05)

but the change of W/D was not statistically significant (P>0.05). SI and EGB may attenuate LIRI through antioxidation

inhibition of neutrophil aggregation and down-regulation of ICAM-1 expression. But EGB had more effect on the antioxidation

while SI did better on regulating ICAM-1 expression.

关键词

Safflor InjectionGinkgo biloba extractionlungischemia-reperfusion injuryintercellular adhesion molecule-1

Keywords

Safflor InjectionGinkgo biloba extractionlungischemia-reperfusion injuryintercellular adhesion molecule-1

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Department of Neurology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine

Department of Pharmacology, Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University

Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College

The Laboratory Research Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences

Yunnan Pharmaceutical Institute

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