Boulet LP, Lemière C, Archambault F, Carrier G, Descary MC, Deschesnes F. Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation. Chest 2006;129:661–668.

Gauvreau GM, Inman MD, Kelly M, Watson RM, Dorman SC, O’Byrne PM. Increased levels of airway neutrophils reduce the inhibitory effects of inhaled glucocorticosteroids on allergen-induced airway eosinophils. Can Respir J 2002;9:26–32.

Douwes J, Gibson P, Pekkanen J, Pearce N. Noneosinophilic asthma: importance and possible mechanisms. Thorax 2002;57:643–648.

Kamath AV, Pavord ID, Ruparelia PR, Chilvers ER. Is the neutrophil the key effector cell in severe asthma? Thorax 2005;60:529–530.

Gundel RH, Wegner CD, Torcellini CA, Letts LG. The role of intercellular adhesion molecule-1 in chronic airway inflammation. Clin Exp Allergy 1992;22:569–575.

Hyduk S, Cybulsky M. VCAM-1 and its functions in development and inflammatory diseases. Prog Inflam Res 2007;141–174

Knudsen H, Andersen CB, Ladefoged SD. Expression of the intercellular adhesion molecule-3 (ICAM-3) in human renal tissue with relation to kidney transplants and various inflammatory diseases. APMIS 1995;103:593–596.

Pilewski JM, Albelda SM. Cell adhesion molecules in asthma: homing, activation, and airway remodeling. Am J Respir Cell Mol Biol 1995;12:1–3.

Yusuf-Makagiansar H, Anderson ME, Yakovleva TV, Murray JS, Siahaan TJ. Inhibition of LFA-1/ICAM-1 and VLA-4/VCAM-1 as a therapeutic approach to inflammation and autoimmune diseases. Med Res Rev 2002;22:146–167.

Guo XG, Chen JZ, Zhang X, Xia Q. Effect of puerarin on L-type calcium channel in isolated rat ventricular myocytes. China J Chin Mater Med (Chin) 2004;29:248–251.

Wang YL, Liu W, Jiang P. Myocardial protective effect of puerarin injection in children with severe pneumonia. Chin J Integr Tradit West Med (Chin) 2005;25:502–504.

Wu L, Qiao H, Li Y, Li L. Cardioprotective effects of the combined use of puerarin and Danshensu on acute ischemic myocardial injury in rats. Phytother Res 2007;21:751–756.

Zhang HY, Liu YH, Wang HQ, Xu JH, Hu HT. Puerarin protects PC12 cells against beta-amyloid-induced cell injury. Cell Biol Int 2008;32:1230–1237.

Gu L, Yang Y, Sun Y, Zheng X. Puerarin inhibits acid sensing ion channels and protects against neuron death induced by acidosis. Planta Med 2010;76:583–588.

Saklatvala J. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol 2004;4:372–377.

Lentsch AB, Ward PA. Regulation of experimental lung inflammation. Respir Physiol 2001;128:17–22.

Malm-Erjefalt M, Stevens T, Perssona C, Erjefalt J. Discontinuous Percoll gradient centrifugation combined with immunomagnetic separation obviates the need for erythrocyte lysis and yields isolated eosinophils with minimal granule abnormalities. J Immunol Methods 2004;288:99–109.

Pang W, Lan XM, Wang CB. Effect of puerarin on the release of interleukin-8 in co-culture of human bronchial epithelial cells and neutrophils. Chin J Integr Med 2012;18:283–287.

Wang CB, Wong CK, Ip WK, Li MLY, Tian YP, Lam CWK. Induction of IL-6 in co-culture of bronchial epithelial cells and eosinophils is regulated by p38 MAPK and NF-kB. Allergy 2005;60:1378–1385.

Wong CK, Li ML, Wang CB, Ip WK, Tian YP, Lam CW. House dust mite allergen Der p 1 elevates the release of inflammatory cytokines and expression of adhesion molecules in co-culture of human eosinophils and bronchial epithelial cells. Int Immunol 2006;18:1327–1335.

Lee IT, Yang CM. Inflammatory signalings involved in airway and pulmonary diseases. Mediators Inflamm 2013; doi:10.1155/2013/791231.

Gerthofer WT, Singer CA. MAPK regulation of gene expression in airway smooth muscle. Respir Physiol Neurobiol 2003;137:237–250.

Liu W, Liang Q, Balzar S, Wenzel S, Gorska M, Alam R. Cell-speciic activation proile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogenactivated protein kinases in asthmatic airways. J Allergy Clin Immunol 2008;121:893–902.

Lee JC, Laydon JT, McDonnell PC. A protein kinase involved in the regulation of inlammatory cytokine biosynthesis. Nature 1994;372:739–746.

Rahman A, Fazal F. Blocking NF-κB: an inflammatory issue. Proceedings Am Horacic Soc 2 2011;8:497–503.

Lee YC, Lee KS, Park SJ. Blockade of airway hyperresponsiveness and inflammation in a marine model of asthma by a prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid. FASEB J 2004;18:1917–1919.

Poynter ME, Irvin CG, Janssen-Heininger YMW. Rapid activation of nuclear factor-κB in airway epithelium in a murine model of allergic airway inflammation. Am J Pathol 2 2002;160:1325–1334.

Tang Y, Zhong ZY, Ge YZ, Sheng GT, Cao PL. Effects of puerarin on the expression of heat shock protein 70 in ischemia/reperfusion injured myocardium. J Clin Rehabil Tissue Eng Res 2007;11:10265–10268.

Wang YX, He LR. Pharmaceutical action of puerarin on cardiovascular system and its mechanisms. Shanghai J Tradit Chin Med (Chin) 2004;38:62–64.

Yang R, Liu A, Ma X, Li L, Su D, Liu J. Sodium tanshinone IIA sulfonate protects cardiomyocytes against oxidative stress-mediated apoptosis through inhibiting JNK activation. J Cardiovasc Pharmacol 2008;51:396–401.

Xie RQ, Du J, Hao YM. Myocardial protection and mechanism of Puerarin Injection on patients of coronary heart disease with ischemia/reperfusion. Chin J Integr Tradit West Med (Chin) 2003;23:895–897.

Hu W, Zhang Q, Yang X, Wang Y, Sun L. Puerarin inhibits adhesion molecule expression in TNF-α-stimulated human endothelial cells via modulation of the nuclear factor κB pathway. Pharmacology 2010;85:27–35.

Zhang SY, Chen G, Wei PF, Huang XS, Dai Y, Shen YJ, et al. The effect of puerarin on serum nitric oxide concentration and myocardial eNOS expression in rats with myocardial infarction. J Asian Natural Products Res 2008;10(3–4):373–381.

Lee JC, PR Young. Role of CSBP/p38/RK stress response kinase in LPS and cytokine signaling mechanisms. J Leukocyte Biol 1996;59:152–157.

Hao LN, Zhang YQ, Shen YH, Wang ZY, Wang YH, Zhang HF, et al. Effect of puerarin on retinal pigment epithelial cells apoptosis induced partly by peroxynitrite via Fas/FasL pathway. Int J Ophthalmol 2010;3:283–287.