Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model

Xiao-bo Chang; Xiao-nong Fan; Shu Wang; Zhi-hong Meng; Xue Yang; Xue-min Shi

doi:10.1007/s11655-013-1530-7

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Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model

Updated：2021-08-27

- Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model
- Chinese Journal of Integrative Medicine Vol. 19, Issue 11, Pages: 853-858(2013)
- Affiliations：
  
  1. College of Acupuncture-Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine,Tianjin,China
  2. Critical Research Room of Encephalopathy Acupuncture Therapy,Tianjin,China
  3. The First Hospital Affiliated to Tianjin University of Traditional Chinese Medicine,Tianjin,China
  4. Class III Laboratory of Acupuncture Quantity-Effect Relationship Affiliated to the State Administration of Traditional Chinese Medicine,Tianjin,China
  5. Mathematics College of Tianjin Polytechnic University,Tianjin,China
  6. Tianjin Key Laboratory of Acupuncture and Moxibustion Science,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the National Program on Key Basic Research Project (973 Program, No. 2006CB504504, 2010CB530500 and 2012 CB 518505)
- DOI：10.1007/s11655-013-1530-7
  CLC：
- Published：2013，
  
  Published Online：30 October 2013，
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Chang, Xb., Fan, Xn., Wang, S. et al. Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model., Chin. J. Integr. Med. 19, 853–858 (2013). https://doi.org/10.1007/s11655-013-1530-7

Xiao-bo Chang, Xiao-nong Fan, Shu Wang, et al. Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model. [J]. Chinese Journal of Integrative Medicine 19(11):853-858(2013)
Chang, Xb., Fan, Xn., Wang, S. et al. Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model., Chin. J. Integr. Med. 19, 853–858 (2013). https://doi.org/10.1007/s11655-013-1530-7 DOI：

Xiao-bo Chang, Xiao-nong Fan, Shu Wang, et al. Cluster analysis for acupoint specificity of acupuncture effect based on cerebral infarction rat model. [J]. Chinese Journal of Integrative Medicine 19(11):853-858(2013) DOI： 10.1007/s11655-013-1530-7.

摘要

To study the acupoint specificity through the comprehensive evaluation of the acupuncture effect on rat model with the middle cerebral artery occlusion (MCAO). Duplicated MCAO model by Zea-longa’s thread ligation was assessed by Zausinger’s six-point method

and rats with 1–3 scores were chosen to be grouped. According to the randomized and controlled principle

rats were divided into 6 basic control groups (including normal group

sham group

model control group

model group without intervention

Nimodipine group

lateral-to-Renzhong group) and 6 acupuncture groups [including Neiguan (PC6) group

Weizhong (BL40) group

Chize (LU5) group

Sanyinjiao (SP6) group

Renzhong (DU6) group and non-acupoint group]; in each acupoint or non-acupoint 9 different parameter combinations were respectively set by orthogonal intersection method. There were in total 60 groups

and each group had 12 rats. The rats were treated by acupuncture with the lifting-thrusting manipulation every 12 h

in total 6 times. Indices of neurobehavioral scores

cerebral blood flow

infarction rate

microcirculation

and light microscope

etc. were measured. In order to comprehensively evaluate the acupuncture effect to research the specificity of acupoint

a cluster analysis was made with SPSS17.0 for the comprehensive effect scores of the samples computed according to the comprehensive evaluation models

and then sorting and classification were made for the comprehensive effect scores. In the acupuncture groups every acupoint had different therapeutic effect due to different acupuncture parameter combinations; among the acupuncture groups the orders of curative effect were as followings: Neiguan group was of exceptional result

Weizhong group and Sanyinjiao group were of valid results in upper level

Chize group and Renzhong group were of valid results in lower level

and non-acupoint group was of invalid result; the therapeutic result of acupoint group was superior to non-acupoint group; and the curative effect of acupuncture group was also superior to basic control group. The acupoint has the specificity of acupuncture effect

and the acupoint specificity is relative.

Abstract

and rats with 1–3 scores were chosen to be grouped. According to the randomized and controlled principle

rats were divided into 6 basic control groups (including normal group

sham group

model control group

model group without intervention

Nimodipine group

lateral-to-Renzhong group) and 6 acupuncture groups [including Neiguan (PC6) group

Weizhong (BL40) group

Chize (LU5) group

Sanyinjiao (SP6) group

and each group had 12 rats. The rats were treated by acupuncture with the lifting-thrusting manipulation every 12 h

in total 6 times. Indices of neurobehavioral scores

cerebral blood flow

infarction rate

microcirculation

and light microscope

etc. were measured. In order to comprehensively evaluate the acupuncture effect to research the specificity of acupoint

a cluster analysis was made with SPSS17.0 for the comprehensive effect scores of the samples computed according to the comprehensive evaluation models

Weizhong group and Sanyinjiao group were of valid results in upper level

Chize group and Renzhong group were of valid results in lower level

and the acupoint specificity is relative.

关键词

model rats of middle cerebral artery occlusionacupuncture effectcomprehensive evaluationacupoint specificitycluster analysis

Keywords

model rats of middle cerebral artery occlusionacupuncture effectcomprehensive evaluationacupoint specificitycluster analysis

references

Tang Y, Yu SG, Liu XG, Li Y, Yin HY, Liang FR. Discussion on ideas and methods of acupoint specificity. Acta Chengdu Univ Tradit Chin Med (Chin) 2007;30(2):3–4.

Linde K, Jobst K, Panton J. Acupuncture for chronic asthma. Cochrane Database Syst Rev 2004;(1):CD000008.

Tulder MW Van, Cherkin DC, Berman B, Lao L, Koes BW. Acupuncture for low back pain. Cochrane Database Syst Rev 2005;(1):CD001351.

White AR, Rampes H, Ernst E. Acupuncture for smoking cessation. Cochrane Database Syst Rev 2006;(1):CD000009.

Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989;20(1):84–91.

Zausinger S, Hungerhuber E, Baethmann A, Reulen H, Schmid-Elsaesser R. Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms. Brain Res 2000;863:94–105.

Li ZR, ed. Experimental acupuncture science. Beijing: China Press of Traditional Chinese Medicine; 2003:327.

Bao XM, Shu SY, eds. The rat brain in stereotaxic coordinates. Beijing: People’s Medical Publishing House 1991;21–29.

Qin LX. State the acupoint non-specificity. Chin J Shanghai Acupunct Moxibust (Chin) 2004;23(12):34–36.

Zhu J, Fu P, Liang J. Advances in studies on acupoints. Chin J Chin Acupunct Moxibust (Chin) 2003;23:183–186.

Yu JC, Yu T, Han JX. Analysis on difference of acupuncture effects between acupoint and non-acupoint from difference of gene expression. Chin J Chin Acupunct Moxibust (Chin) 2002;22:749–751.

Xu WD, Liu X, Zhu B. Study on the central mechanism of specificity and extensiveness of EA action in suppressing nociceptive response of trigeminal convergent neurons. Chin J Acupunct Res (Chin) 2000;25:248–253.

Chen RX, Kang MF. Clinical application of acupoint heatsensitization. Chin J Chin Acupunct Moxibust (Chin) 2007;27:199–202.

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