Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats

Min-you Qi; Gao-yu Xie; Kai Chen; Yan-hui Su; Su-qing Yu; Hao-ran Liu

doi:10.1007/s11655-013-1532-5

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Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats

Updated：2021-08-27

- Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats
- Chinese Journal of Integrative Medicine Vol. 20, Issue 6, Pages: 456-461(2014)
- Affiliations：
  
  1. Department of Pharmacology, College of Pharmaceutical Sciences, Zhejiang University of Technology,Hangzhou,China
  2. Department of Basic Guiyang College of Traditional Chinese Medicine,Guiyang,China
  3. Department of Pharmacy, College of Chemical and Chemistry Engineering, Hu’nan University,Changsha,China
- Author bio：
- Funds：
  
  Supported by a Project Supported by Scientific Research Fund of Zhejiang Provincial Education Department (No. Z201121669) and a Project of Chinese Medica Science Foundation of Zhejiang Province (No. 2009CA080);These authors contribute equally to this work
- DOI：10.1007/s11655-013-1532-5
  CLC：
- Published：2014，
  
  Published Online：28 January 2014，
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Qi, My., Xie, Gy., Chen, K. et al. Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats., Chin. J. Integr. Med. 20, 456–461 (2014). https://doi.org/10.1007/s11655-013-1532-5

Min-you Qi, Gao-yu Xie, Kai Chen, et al. Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats. [J]. Chinese Journal of Integrative Medicine 20(6):456-461(2014)
Qi, My., Xie, Gy., Chen, K. et al. Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats., Chin. J. Integr. Med. 20, 456–461 (2014). https://doi.org/10.1007/s11655-013-1532-5 DOI：

Min-you Qi, Gao-yu Xie, Kai Chen, et al. Total triterpene acids, isolated from Corni Fructus, ameliorate progression of renal damage in streptozotocin-induced diabetic rats. [J]. Chinese Journal of Integrative Medicine 20(6):456-461(2014) DOI： 10.1007/s11655-013-1532-5.

摘要

To investigate whether total triterpene acids (TTAs)

isolated from Cornus Fructus

attenuates renal function by reducing oxidative stress and down-regulating the expression of transforming growth factor β1 (TGF-β1). Diabetes was induced by an injection of streptozotocin (40 mg/kg intravenously). Thirty rats were randomly divided into three groups: control group

diabetic model group and TTAs treatment group (50 mg/kg

intragastrically) administrated for 8 weeks from 5th to 12th week. All rats were anaesthetized and then were killed to remove kidneys. The renal function and redox enzyme system parameters were tested. Glomerular morphology was observed by a light microscopy. Immunohistochemistry and Western blot assays were employed to determine the protein levels of TGF-β1. TTAs attenuated the levels of urinary protein

serum creatinine and blood urea nitrogen

although it did not significantly reduce the level of glucose. In addition

TTAs decreased the malondialdehyde while increased superoxide dismutase

catalase and glutathione peroxide activities in diabetic rats. The renal pathological changes in TTAs treatment group were ameliorated. Furthermore

TTAs also ameliorated the expression of TGF-β1. TTAs improved renal function via reducing oxidative stress and down-regulation the expression of TGF-β1 in diabetic rats.

Abstract

To investigate whether total triterpene acids (TTAs)

isolated from Cornus Fructus

diabetic model group and TTAs treatment group (50 mg/kg

serum creatinine and blood urea nitrogen

although it did not significantly reduce the level of glucose. In addition

TTAs decreased the malondialdehyde while increased superoxide dismutase

catalase and glutathione peroxide activities in diabetic rats. The renal pathological changes in TTAs treatment group were ameliorated. Furthermore

TTAs also ameliorated the expression of TGF-β1. TTAs improved renal function via reducing oxidative stress and down-regulation the expression of TGF-β1 in diabetic rats.

关键词

total triterpene acidsdiabetic nephropathyoxidative stresstransforming growth factor β1

Keywords

total triterpene acidsdiabetic nephropathyoxidative stresstransforming growth factor β1

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