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Research progress of ursolic acid’s anti-tumor actions
- Chinese Journal of Integrative Medicine Vol. 20, Issue 1, Pages: 72-79(2014)
- Affiliations：
Pharmacology Department, Dalian Medical University,Liaoning Province,Dalian,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China ( No. 30772601)
DOI：10.1007/s11655-013-1541-4
CLC：Published：2014，
Published Online：29 December 2013，
Scan for full text
Zang, Ll., Wu, Bn., Lin, Y. et al. Research progress of ursolic acid’s anti-tumor actions., Chin. J. Integr. Med. 20, 72–79 (2014). https://doi.org/10.1007/s11655-013-1541-4
Li-li Zang, Bao-ning Wu, Yuan Lin, et al. Research progress of ursolic acid’s anti-tumor actions. [J]. Chinese Journal of Integrative Medicine 20(1):72-79(2014)
Zang, Ll., Wu, Bn., Lin, Y. et al. Research progress of ursolic acid’s anti-tumor actions., Chin. J. Integr. Med. 20, 72–79 (2014). https://doi.org/10.1007/s11655-013-1541-4 DOI：
Li-li Zang, Bao-ning Wu, Yuan Lin, et al. Research progress of ursolic acid’s anti-tumor actions. [J]. Chinese Journal of Integrative Medicine 20(1):72-79(2014) DOI： 10.1007/s11655-013-1541-4.
摘要
Ursolic acid (UA) is a sort of pentacyclic triterpenoid carboxylic acid purified from natural plant. UA has a series of biological effects such as sedative
anti-inflammatory
anti-bacterial
anti-diabetic
antiulcer
etc. It is discovered that UA has a broad-spectrum anti-tumor effect in recent years
which has attracted more and more scholars’ attention. This review explained anti-tumor actions of UA
including (1) the protection of cells’ DNA from different damages; (2) the anti-tumor cell proliferation by the inhibition of epidermal growth factor receptor/mitogen-activated protein kinase signal or of FoxM1 transcription factors
respectively; (3) antiangiogenesis
(4) the immunological surveillance to tumors; (5) the inhibition of tumor cell migration and invasion; (6) the effect of UA on caspase
cytochromes C
nuclear factor kappa B
cyclooxygenase
tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or mammalian target of rapamycin signal to induce tumor cell apoptosis respectively
and etc. Moreover
UA has selective toxicity to tumor cells
basically no effect on normal cells. With further studies
UA would be one of the potential anti-tumor agents.
Abstract
Ursolic acid (UA) is a sort of pentacyclic triterpenoid carboxylic acid purified from natural plant. UA has a series of biological effects such as sedative
anti-inflammatory
anti-bacterial
anti-diabetic
antiulcer
etc. It is discovered that UA has a broad-spectrum anti-tumor effect in recent years
which has attracted more and more scholars’ attention. This review explained anti-tumor actions of UA
including (1) the protection of cells’ DNA from different damages; (2) the anti-tumor cell proliferation by the inhibition of epidermal growth factor receptor/mitogen-activated protein kinase signal or of FoxM1 transcription factors
respectively; (3) antiangiogenesis
(4) the immunological surveillance to tumors; (5) the inhibition of tumor cell migration and invasion; (6) the effect of UA on caspase
cytochromes C
nuclear factor kappa B
cyclooxygenase
tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) or mammalian target of rapamycin signal to induce tumor cell apoptosis respectively
and etc. Moreover
UA has selective toxicity to tumor cells
basically no effect on normal cells. With further studies
UA would be one of the potential anti-tumor agents.
关键词
Ursolic Acidanti-tumorresearch progress
Keywords
Ursolic Acidanti-tumorresearch progress
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