Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats

Hui Dong; Jian-hong Wang; Fu-er Lu; Li-jun Xu; Yan-lin Gong; Xin Zou

doi:10.1007/s11655-013-1560-1

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Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats

Updated：2021-08-27

- Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats
- Chinese Journal of Integrative Medicine Vol. 19, Issue 9, Pages: 668-674(2013)
- Affiliations：
  
  Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by grants from National Natural Science Foundation of China (No. 30801492)
- DOI：10.1007/s11655-013-1560-1
  CLC：
- Published：2013，
  
  Published Online：24 August 2013，
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Dong, H., Wang, Jh., Lu, Fe. et al. Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats., Chin. J. Integr. Med. 19, 668–674 (2013). https://doi.org/10.1007/s11655-013-1560-1

Hui Dong, Jian-hong Wang, Fu-er Lu, et al. Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats. [J]. Chinese Journal of Integrative Medicine 19(9):668-674(2013)
Dong, H., Wang, Jh., Lu, Fe. et al. Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats., Chin. J. Integr. Med. 19, 668–674 (2013). https://doi.org/10.1007/s11655-013-1560-1 DOI：

Hui Dong, Jian-hong Wang, Fu-er Lu, et al. Jiaotai pill (交泰丸) enhances insulin signaling through phosphatidylinositol 3-kinase pathway in skeletal muscle of diabetic rats. [J]. Chinese Journal of Integrative Medicine 19(9):668-674(2013) DOI： 10.1007/s11655-013-1560-1.

摘要

To investigate the effect of Jiaotai Pill (交泰丸

JTP) at different constitutional proportions on insulin signaling through phosphatidylinositol 3-kinase (PI3K) pathway in the skeletal muscle of diabetic rats. The rat model of type 2 diabetes mellitus (T2DM) was established by intravenous injection of a small dose of streptozotoein plus high fat diet feeding. JTP at the same dosage of cinnamon and the increasing dosage of Coptis chinensis was administered to diabetic rats for nine weeks respectively. Plasma glucose and insulin levels were assayed. The expressions of proteins were determined by Western blot method. All the three formulations of JTP decreased plasma glucose and fasting insulin levels as well as increased the protein expressions of insulin receptor β (InsRβ) subunit

insulin receptor substrate-1 (IRS-1)

PI3K p85 subunit and glucose transporter 4 (GLUT4) in skeletal muscle. Meanwhile

JTP increased the tyrosine phosphorylation of InsRβ subunit and IRS-1

and reduced the serine phosphorylation of IRS-1 in skeletal muscle. Interestingly

the effect of JTP on improving insulin sensitivity was not dose-dependent. In contrast

JTP containing the least amount of Coptis chinensis exhibited the best effect. JTP at different constitutional proportions attenuates the development of diabetes in a rat model of T2DM. The mechanism might be associated with enhancing insulin signaling through PI3K pathway in the skeletal muscle.

Abstract

To investigate the effect of Jiaotai Pill (交泰丸

insulin receptor substrate-1 (IRS-1)

PI3K p85 subunit and glucose transporter 4 (GLUT4) in skeletal muscle. Meanwhile

JTP increased the tyrosine phosphorylation of InsRβ subunit and IRS-1

and reduced the serine phosphorylation of IRS-1 in skeletal muscle. Interestingly

the effect of JTP on improving insulin sensitivity was not dose-dependent. In contrast

关键词

Jiaotai Pillinsulin signalingphosphatidylinositol 3-kinaseskeletal musclediabetes mellitusChinese Medicine

Keywords

Jiaotai Pillinsulin signalingphosphatidylinositol 3-kinaseskeletal musclediabetes mellitusChinese Medicine

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Related Institution

Department of Cardiology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

Shandong University of Traditional Chinese Medicine

Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College

Experiment Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology

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