Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome

Guo-lin Wu; Tian-yi Li; Yong-sheng Fan; Guo-you Yu; Jiu Chen

doi:10.1007/s11655-013-1565-9

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Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome

Updated：2021-08-27

- Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome
- Chinese Journal of Integrative Medicine Vol. 19, Issue 9, Pages: 696-700(2013)
- Affiliations：
  
  1. The First Affiliated Hospital of Medical College of Zhejiang University,Hangzhou,China
  2. Zhejiang University of Chinese Medicine,Hangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-013-1565-9
  CLC：
- Published：2013，
  
  Published Online：24 August 2013，
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Wu, Gl., Li, Ty., Fan, Ys. et al. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome., Chin. J. Integr. Med. 19, 696–700 (2013). https://doi.org/10.1007/s11655-013-1565-9

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome. [J]. Chinese Journal of Integrative Medicine 19(9):696-700(2013)
Wu, Gl., Li, Ty., Fan, Ys. et al. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome., Chin. J. Integr. Med. 19, 696–700 (2013). https://doi.org/10.1007/s11655-013-1565-9 DOI：

Guo-lin Wu, Tian-yi Li, Yong-sheng Fan, et al. Effect of Chinese herbal medicine for nourishing yin, supplementing qi, and activating blood on the Th1/Th2 immune balance in peripheral blood in patients with primary Sjogren’s syndrome. [J]. Chinese Journal of Integrative Medicine 19(9):696-700(2013) DOI： 10.1007/s11655-013-1565-9.

摘要

To observe the effect of Chinese herbal medicine for nourishing yin

supplementing qi

and activating blood on the expression of interferon-γ (IFN-γ)/interleukin-4 (IL-4) in peripheral blood and disease activity in primary Sjogren’s syndrome (pSS) patients

and to study the relationship between the immune balance of Th1/Th2 and the disease activity. A total of 66 pSS patients were randomized with tossing coins method into two groups: the integrative therapy group (34 cases) and the control group (32 cases); and 28 healthy subjects were taken as the normal group. The integrative therapy group was treated by Chinese herbal medicines for nourishing yin

supplementing qi

and activating blood combined with hydroxychloroquine sulfate tablets and the control group was treated with hydroxychloroquine sulfate tablets. The treatment course was 3 months for both groups. The levels of serum immunoglobulin G (IgG)

erythrocyte sedimentation rate (ESR)

IFN-γ and IL-4 in peripheral blood were measured before and after treatment. Compared with the normal group

the levels of IgG

ESR

IFN-γ and IL-4 were significantly increased in pSS patients (P<0.05). Remarkably

after 3 months of treatment

these levels were dramatically decreased in both the integrative therapy group and the control group

although still higher than the normal group. The levels of IgG

ESR

IFN-γ and IL-4 in the integrative therapy group were lower than the control group and the same group before treatment (P<0.05). The ratio of IFN-γ/IL-4 also significantly decreased after treatment. Moreover

the level of IFN-γ and the ratio of IFN-γ/IL-4 in the integrative theraphy group were significantly lower than the control group (P<0.05). For all patients the ratio of IFN-γ/IL-4 before and after treatment was positive correlated with the levels of IgG and ESR. Chinese herbal medicine for nourishing yin

supplementing qi

and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

Abstract

To observe the effect of Chinese herbal medicine for nourishing yin

supplementing qi

and activating blood on the expression of interferon-γ (IFN-γ)/interleukin-4 (IL-4) in peripheral blood and disease activity in primary Sjogren’s syndrome (pSS) patients

supplementing qi

erythrocyte sedimentation rate (ESR)

IFN-γ and IL-4 in peripheral blood were measured before and after treatment. Compared with the normal group

the levels of IgG

ESR

IFN-γ and IL-4 were significantly increased in pSS patients (P<0.05). Remarkably

after 3 months of treatment

these levels were dramatically decreased in both the integrative therapy group and the control group

although still higher than the normal group. The levels of IgG

ESR

supplementing qi

and activating blood can alleviate the disease activity of pSS by regulating the immune balance of Th1/Th2.

关键词

primary Sjogren’s syndromeChinese Herbal Medicinenourishing Yinsupplementing qiand activating bloodinterferon-γinterleukin-4disease activity

Keywords

primary Sjogren’s syndromeChinese Herbal Medicinenourishing Yinsupplementing qiand activating bloodinterferon-γinterleukin-4disease activity

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The First Affiliated Hospital, College of Medicine, Zhejiang University

The First Affiliated Hospital of Medical School of Zhejiang University

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Cardiovascular Diseases Centre, Xiyuan Hospital, China Academy of Chinese Medical Sciences

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