Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase

He-ping Xie; Hong-zhi Yang; Wei-kang Wu; Wei-bing Guan; Qian-shan Ke; Yong-wei Li; Min Dai; Ge-min Xiao; Jiong-shan Zhang; Yang-mei Li

doi:10.1007/s11655-013-1569-5

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Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase

Updated：2021-08-27

- Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase
- Chinese Journal of Integrative Medicine Vol. 20, Issue 2, Pages: 94-100(2014)
- Affiliations：
  
  Traditional Chinese Medicine & Acupuncture Department, The Third Affiliated Hospital of Sun Yet-sen University,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by Grants from the National Major Projects for AIDS and Viral Hepatitis of China (No.2008ZX10005-008)
- DOI：10.1007/s11655-013-1569-5
  CLC：
- Published：2014，
  
  Published Online：6 March 2014，
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Xie, Hp., Yang, Hz., Wu, Wk. et al. Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase., Chin. J. Integr. Med. 20, 94–100 (2014). https://doi.org/10.1007/s11655-013-1569-5

He-ping Xie, Hong-zhi Yang, Wei-kang Wu, et al. Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase. [J]. Chinese Journal of Integrative Medicine 20(2):94-100(2014)
Xie, Hp., Yang, Hz., Wu, Wk. et al. Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase., Chin. J. Integr. Med. 20, 94–100 (2014). https://doi.org/10.1007/s11655-013-1569-5 DOI：

He-ping Xie, Hong-zhi Yang, Wei-kang Wu, et al. Chinese medicine syndrome distribution of chronic hepatitis b virus carriers in immunotolerant phase. [J]. Chinese Journal of Integrative Medicine 20(2):94-100(2014) DOI： 10.1007/s11655-013-1569-5.

摘要

To explore Chinese medicine (CM) syndrome distribution of chronic hepatitis B virus (HBV) carriers in immunotolerant phase (ITP). One hundred and eighty-five chronic HBV carriers in ITP

seen in the Third Affiliated Hospital of Sun Yat-sen University from May 2009 to December 2010

were admitted in an observational study under the guidance of CM. Patients’ CM symptoms and signs

demographics

liver biochemistries

and qualitative HBV DNA were recorded in the questionnaires. CM syndromes were then differentiated to 15 detailed types and analyzed by generalization. Lastly

the location

pathogenic factors and nature of the disease were also assessed. When CM syndrome patterns were differentiated to 15 types

there were 27 (15%) no syndrome cases

94 (50%) single syndrome cases and 64 (35%) compound syndromes cases. The main detailed syndromes included Liver (Gan)-qi depression (LQD)

Kidney (Shen)-qi deficiency (KQD)

Spleen (Pi)-qi deficiency (SQD) and Kidney-yang deficiency (KYAD). After CM syndromes generalized to five types

their frequency was Spleen-Kidney deficiency (SKD)>LQD>inner dampness-heat retention (IDHR)>Liver-Kidney deficiency (LKD)>blood stasis blocking collateral (BSBC). SKD and LQD occupied 64%. The disease location included Liver

Gallbladder (Dan)

Spleen

Stomach (Wei) and Kidney. The pathogenic factors were mainly qi stagnation

qi deficiency

yang deficiency

concurrently dampness-heat and blood stasis. The deficiency syndrome was more than excess syndrome in its nature. Most of chronic HBV carriers in ITP have their CM syndrome

and the most common types are SKAD

LQD. This study suggests that the natural history may be improved through breaking the state of immune tolerance or shorten the time of ITP by strengthening Spleen-Kidney and reliving Liver qi.

Abstract

To explore Chinese medicine (CM) syndrome distribution of chronic hepatitis B virus (HBV) carriers in immunotolerant phase (ITP). One hundred and eighty-five chronic HBV carriers in ITP

seen in the Third Affiliated Hospital of Sun Yat-sen University from May 2009 to December 2010

were admitted in an observational study under the guidance of CM. Patients’ CM symptoms and signs

demographics

liver biochemistries

and qualitative HBV DNA were recorded in the questionnaires. CM syndromes were then differentiated to 15 detailed types and analyzed by generalization. Lastly

the location

pathogenic factors and nature of the disease were also assessed. When CM syndrome patterns were differentiated to 15 types

there were 27 (15%) no syndrome cases

94 (50%) single syndrome cases and 64 (35%) compound syndromes cases. The main detailed syndromes included Liver (Gan)-qi depression (LQD)

Kidney (Shen)-qi deficiency (KQD)

Spleen (Pi)-qi deficiency (SQD) and Kidney-yang deficiency (KYAD). After CM syndromes generalized to five types

Gallbladder (Dan)

Spleen

Stomach (Wei) and Kidney. The pathogenic factors were mainly qi stagnation

qi deficiency

yang deficiency

concurrently dampness-heat and blood stasis. The deficiency syndrome was more than excess syndrome in its nature. Most of chronic HBV carriers in ITP have their CM syndrome

and the most common types are SKAD

LQD. This study suggests that the natural history may be improved through breaking the state of immune tolerance or shorten the time of ITP by strengthening Spleen-Kidney and reliving Liver qi.

关键词

hepatitis B virus carriernatural historyimmune toleranceChinese MedicineSyndrome Differentiation

Keywords

hepatitis B virus carriernatural historyimmune toleranceChinese MedicineSyndrome Differentiation

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