Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats

Yi-jing Lv; Gui-lin Liu; Xu-ming Ji; Cun-zhong Yuan; Bo Wang; Min Ren; Lei Yan; Xu-ping Wang; Ji-dong Zhang

doi:10.1007/s11655-013-1572-x

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Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats

Updated：2021-08-27

- Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats
- Chinese Journal of Integrative Medicine Vol. 19, Issue 9, Pages: 689-695(2013)
- Affiliations：
  
  1. Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University,Jinan,China
  2. Shandong Univesity of Traditional Chinese Medicine,Jinan,China
  3. School of Basic Medical Science, Shandong University of Traditional Chinese Medicine,Jinan,China
  4. Gynecology Oncology Key Laboratory of Shandong Province, Qilu Hospital, Shandong University,Jinan,China
  5. Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University,Jinan,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No.30873324) and the Development of Science and Technology Plan Projects of Shandong Province (No. 2010GWZ20242)
- DOI：10.1007/s11655-013-1572-x
  CLC：
- Published：2013，
  
  Published Online：24 August 2013，
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Lv, Yj., Liu, Gl., Ji, Xm. et al. Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats., Chin. J. Integr. Med. 19, 689–695 (2013). https://doi.org/10.1007/s11655-013-1572-x

Yi-jing Lv, Gui-lin Liu, Xu-ming Ji, et al. Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats. [J]. Chinese Journal of Integrative Medicine 19(9):689-695(2013)
Lv, Yj., Liu, Gl., Ji, Xm. et al. Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats., Chin. J. Integr. Med. 19, 689–695 (2013). https://doi.org/10.1007/s11655-013-1572-x DOI：

Yi-jing Lv, Gui-lin Liu, Xu-ming Ji, et al. Qindan capsule (芩丹胶囊) changes adventitial collagen synthesis in spontaneously hypertensive rats. [J]. Chinese Journal of Integrative Medicine 19(9):689-695(2013) DOI： 10.1007/s11655-013-1572-x.

摘要

To investigate the effect of Qindan Capsule (芩丹胶囊

QC) on collagen synthesis and the mechanism underlying the process in spontaneously hypertensive rats (SHRs). Twentyfour SHRs were divided into three groups: the hypertension model group

the QC treatment group

and the losartan treatment group. Eight Wistar Kyoto (WKY) rats were used as the normal control group. The systolic blood pressure (SBP) of the rats was monitored

and the thoracic aorta adventitia of the rats was segregated. The expressions of transforming growth factor 1 (TGF-β1)

Smad3

and collagens I and were measured by histological staining and reverse transcription polymerase chain reaction. The SBP was significantly higher in the model group than in the normal control group (P<0.01). However

a significant SBP-lowering effect was observed in QC or losartan treatment groups (P<0.05 or P<0.01) after 3 weeks of treatment. QC-treated rats showed a decrease of approximately 40 mm Hg

and the losartan-treated rats showed a decrease of approximately 50 mm Hg at the end of treatment compared with the beginning of treatment. The protein and gene levels of TGF-β1

Smad3

and collagens I and in the model group were significantly increased compared with those in the normal control group (P<0.01). However

the levels were significantly decreased in the QC or losartan treatment group compared with the model group (P<0.05 or P<0.01). However

there was no significant difference between the QC and losartan treatment groups (P<0.05). QC could exert its antihypertensive effect through down-regulating TGF-β1-stimulated collagen expressions. The TGF-β1/Smad3 signaling pathway may be involved in this process.

Abstract

To investigate the effect of Qindan Capsule (芩丹胶囊

QC) on collagen synthesis and the mechanism underlying the process in spontaneously hypertensive rats (SHRs). Twentyfour SHRs were divided into three groups: the hypertension model group

the QC treatment group

and the losartan treatment group. Eight Wistar Kyoto (WKY) rats were used as the normal control group. The systolic blood pressure (SBP) of the rats was monitored

and the thoracic aorta adventitia of the rats was segregated. The expressions of transforming growth factor 1 (TGF-β1)

Smad3

a significant SBP-lowering effect was observed in QC or losartan treatment groups (P<0.05 or P<0.01) after 3 weeks of treatment. QC-treated rats showed a decrease of approximately 40 mm Hg

and the losartan-treated rats showed a decrease of approximately 50 mm Hg at the end of treatment compared with the beginning of treatment. The protein and gene levels of TGF-β1

Smad3

and collagens I and in the model group were significantly increased compared with those in the normal control group (P<0.01). However

the levels were significantly decreased in the QC or losartan treatment group compared with the model group (P<0.05 or P<0.01). However

关键词

Qindan Capsulecollagentransforming growth factor 1Smadhypertensionrat

Keywords

Qindan Capsulecollagentransforming growth factor 1Smadhypertensionrat

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