Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials

Run Pu; Xiang-nan Geng; Fei Yu; Hui-gang Liang; Lu-wen Shi

doi:10.1007/s11655-013-1591-7

Your Location：

Home >

Browse articles >

Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials

Updated：2021-08-27

- Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials
- Chinese Journal of Integrative Medicine Vol. 19, Issue 10, Pages: 783-791(2013)
- Affiliations：
  
  1. Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmaceutical Sciences, Peking University Health Science Center,Beijing,China
  2. Chinese Pharmaceutical Association,Beijing,China
  3. Peking University First Hospital,Beijing,China
  4. Center for Healthcare Management Systems, East Carolina University,Greenville,USA
- Author bio：
- Funds：
  
  Supported by the National Key Technology Research and Development Program of the People’s Republic of China (No. 2009BAI76B030900)
- DOI：10.1007/s11655-013-1591-7
  CLC：
- Published：2013，
  
  Published Online：4 October 2013，
Scan for full text
Pu, R., Geng, Xn., Yu, F. et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 19, 783–791 (2013). https://doi.org/10.1007/s11655-013-1591-7

Run Pu, Xiang-nan Geng, Fei Yu, et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 19(10):783-791(2013)
Pu, R., Geng, Xn., Yu, F. et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 19, 783–791 (2013). https://doi.org/10.1007/s11655-013-1591-7 DOI：

Run Pu, Xiang-nan Geng, Fei Yu, et al. Liuwei Dihuang Pills (六味地黄丸) enhance the effect of Western medicine in treating type 2 diabetes: A meta-analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 19(10):783-791(2013) DOI： 10.1007/s11655-013-1591-7.

摘要

To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (六味地黄丸

LDP) to Western medicine in improving treatment outcomes for type 2 diabetes. Medline

PubMed

Cochrane Library

and Chinese databases

including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e.

if the study involved a randomized clinical trial in which the experimental group combined LDP with Western drugs and the control group used the corresponding Western drugs alone to treat type 2 diabetes. Outcomes were measured in terms of fasting blood glucose (FBG)

postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR)

mean difference (MD)

and 95% confidence intervals (95% CI) were calculated. Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1

609 patients from 18 studies were included. We found that adding LDP can lower patients’ FBG (MD=0.54 mmol/L

95% CI [0.15

0.93]

P=0.007)

2hPG (MD=1.05 mmol/L

95% CI [0.29

1.81]

P<0.01) and HbA1c (MD=0.23

95% CI [0.02

0.45]

P=0.008). There were also improvements in treatment response rates (OR=3.41

95% CI [2.38

4.90]

P<0.01) and control rates (OR=2.47

95% CI [1.91

3.20]

P<0.01). Adding LDP to Western medicine might improve treatment outcomes of diabetes

including FBG

2hPG

response rates and control rates.

Abstract

To perform meta-analyses evaluating the efficacy of adding Liuwei Dihuang Pills (六味地黄丸

LDP) to Western medicine in improving treatment outcomes for type 2 diabetes. Medline

PubMed

Cochrane Library

and Chinese databases

including the Chinese National Knowledge Infrastructure were searched to identify eligible studies; i.e.

postprandial blood glucose (2hPG) and HbA1c level. Efficacy was also measured by using control and response rates. The combined odds ratio (OR)

mean difference (MD)

and 95% confidence intervals (95% CI) were calculated. Studies included in the analysis were less adequate than expected in terms of methodological quality. A total of 1

609 patients from 18 studies were included. We found that adding LDP can lower patients’ FBG (MD=0.54 mmol/L

95% CI [0.15

0.93]

P=0.007)

2hPG (MD=1.05 mmol/L

95% CI [0.29

1.81]

P<0.01) and HbA1c (MD=0.23

95% CI [0.02

0.45]

P=0.008). There were also improvements in treatment response rates (OR=3.41

95% CI [2.38

4.90]

P<0.01) and control rates (OR=2.47

95% CI [1.91

3.20]

P<0.01). Adding LDP to Western medicine might improve treatment outcomes of diabetes

including FBG

2hPG

response rates and control rates.

关键词

meta-analysesLiuwei Dihuang Pillstype 2 diabetesFasting Blood Glucosepostprandial blood glucosehemoglobin A1c

Keywords

meta-analysesLiuwei Dihuang Pillstype 2 diabetesFasting Blood Glucosepostprandial blood glucosehemoglobin A1c

references

Danaei G, Finucane MM, Lu Y, Singh GM, Cowan MJ, Paciorek CJ, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011;378:31–40.

Xie Q. Research on the effect of Liuwei Dihuang Pills on treating type 2 diabetes. Clin J Chin Med (Chin) 2013;5:116–118.

Li KJ. Systematic assessment of RCTs on Six-Ingredient Rehmannia Pills’ efficacy in treating type 2 diabetes. Shandong J Tradit Chin Med (Chin) 2009;28:684–685.

Nicola Robinson. Integrative medicine — Traditional Chinese medicine, a model ? Chin J Integr med 2011;17:21–25.

Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0. The Cochrane Collaboration, 2011. Available from www.cochranehandbook.org.

Lin L. Standard of diagnosis and treatment of diabetes with combination of TCM and Western medicine. Chin J Integr Tradit West Med (Chin) 2005;25:94–95.

Zhang CX. Six-Ingredient Rehmannia Pills’ efficacy on diabetes. West China Med J (Chin) 2010;25:1137–1138.

Dai DY. A clinical trial on the efficacy of Six-Ingredient Rehmannia Pills and its modified prescriptions to treat type 2 diabetes. J Med Forum 2008;29(18):85–86.

Zhang FD. Thirty-eight trials on the combination of TCM and Western therapies to treat diabetes. Chin J Ethnomed Ethnopharm (Chin) 2010;126–127.

Gu GL. Adjuvant efficacy of Six-Ingredient Rehmannia Pills on the initial diagnosis of type 2 diabetes. J Community Med (Chin) 2011;9(7):41–42.

Jiang XL. Combination of TCM and Western therapies to treat obesity-related type 2 diabetes: an analysis of sixty cases. Chin J Celiopathy 2005;5:665–666.

Lang NQL, Wang HS. Clinical observation of type 2 diabetes treated with modified decoction of Six-Ingredient Rehmannia Pills. J Chengdu Univ Tradit Chin Med (Chin) 2000;23(4):46–47.

Lin YW. Efficacy of Six-Ingredient Rehmannia Pills and its modified prescriptions on type 2 diabetes. Zhejiang J Integr Tradit Chin West Med (Chin) 2002;12:373.

Lin Y, Chen SG. Combination of traditional Chinese medicine and Western therapies to treat diabetes: an analysis of thirty-eight cases. Modern Tradit Chin Med (Chin) 2010;30(1):16–17.

Liu S, Yang M, Zhang B. Impact of Six-Ingredient Rehmannia Pills combined with insulin pump on insulin sensitivity in the treatment of type 2 diabetes with yin-deficiency. J Pract Tradit Chin Intern Med (Chin) 2009;23(4):72–73.

Sun QH, Wang SQ. Clinical observance of sixty-two cases on the efficacy of Six-Ingredient Rehmannia Pills combined with diamicron to treat type 2 diabetes. Chin Modern Med Clin (Chin) 2006;5(2):10–11.

Wen LX, Chen CS. Fifty-eight clinical trials on Six-Ingredient Rehmannia Pills’ efficacy on type 2 diabetes. Chin Community Doctors (Chin) 2010;3:82.

Xi YP. Adjuvant efficacy of Six-Ingredient Rehmannia Pills and its modified prescriptions on type 2 diabetes: an analysis of forty-eight cases. Clin J Anhui Tradit Chin Med (Chin) 2002;14(1):5.

Zhang J. Combination of TCM and Western therapies to treat type 2 diabetes: an analysis of fifty-six cases. J Pract Tradit Chin Med (Chin) 2003;19(2):80.

Zhao ZY. Clinical observance of supplemented Six-Ingredient Rehmannia Pills’ efficacy on type 2 diabetes with qi and yin deficiency. China Foreign Med J (Chin) 2006;4(8):65–68.

Zhou JH, Yu QP. Combination of Six-Ingredient Rehmannia Pills and berberine in the treatment of senile diabetes: a clinical analysis of forty-eight cases. Strait Pharmac J (Chin) 1999;11(4):57–58.

Zou SC. Efficacy of glibenclamide and Six-Ingredient Rehmannia Pills on type 2 diabetes. Zhejiang J Integr Tradit Chin West Med (Chin) 2009;19:420–421.

Zhao M, Li W. Observation of Liuwei Dihuang Pill combined with glinides efficacy in the treatment of type 2 diabetes. Modern J Integr Tradit Chin West Med (Chin) 2013;22(1):47–49.

Dai F, Zhang JS. Observation of the effect of metformin combined with the SIRP in the treatment of type 2 diabetes. Pract J Cardiac Cerebr Pneumal Vasc Dis (Chin) 2012;20:1887.

FULL TEXT LINK

More>

Views

933

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effects of royal jelly supplementation on glycemic control and oxidative stress factors in type 2 diabetic female: A randomized clinical trial

Clinical observation of opuntia dillenii tablet in treating type 2 diabetes mellitus

Preliminary study on relationship between tcm syndrome-type and insulin resistance in coronary heart disease

Prevention of tumor necrosis factor-a induced insulin resistance by Radix Astragali

Changes of leucocytic estrogen receptor levels in patients with climacteric syndrome and the therapeutic effects of Liuwei Dihuang Pills (六位地黄)

Related Author

No data

Related Institution

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz

Endocrinology Department of Medicine Faculty, Tabriz University of Medical Sciences, Tabriz

Student Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz

Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz

Zhejiang Provincial People’s Hospital

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰