Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery

Fu-hai Zhao; Jian-gang Liu; Xin Wang; Da-wu Zhang; Pei-li Wang; Lei Zhang; Jian-peng Du; Xin-zhi Li; Yan-lei Ma; Yue Shi; Da-zhuo Shi

doi:10.1007/s11655-013-1596-2

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Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery

Updated：2021-08-27

- Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery
- Chinese Journal of Integrative Medicine Vol. 19, Issue 10, Pages: 771-776(2013)
- Affiliations：
  
  Cardiovascular Center of Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 81072931) and National Health Fund (No. CMH200701110)
- DOI：10.1007/s11655-013-1596-2
  CLC：
- Published：2013，
  
  Published Online：4 October 2013，
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Zhao, Fh., Liu, Jg., Wang, X. et al. Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery., Chin. J. Integr. Med. 19, 771–776 (2013). https://doi.org/10.1007/s11655-013-1596-2

Fu-hai Zhao, Jian-gang Liu, Xin Wang, et al. Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery. [J]. Chinese Journal of Integrative Medicine 19(10):771-776(2013)
Zhao, Fh., Liu, Jg., Wang, X. et al. Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery., Chin. J. Integr. Med. 19, 771–776 (2013). https://doi.org/10.1007/s11655-013-1596-2 DOI：

Fu-hai Zhao, Jian-gang Liu, Xin Wang, et al. Long-term effect of stent coating with zedoary essential components on neointimal formation in the porcine coronary artery. [J]. Chinese Journal of Integrative Medicine 19(10):771-776(2013) DOI： 10.1007/s11655-013-1596-2.

摘要

To examine the effect of the zedoary essential component-eluting stent (ZES) on a porcine coronary neointimal formation. ZES

sirolimus-eluting stents (SES)

and bare metal stents (BMS) were randomly implanted in three different major epicardial vessels in 36 balloon-injured pigs. Coronary angiography

optical coherence tomography

and histomorphological analysis were used to determine antihyperplasia effects. ZES and SES had a significantly larger lumen diameter and area

and reduced diameter and area of stenosis in arteries at 30 and 90 days compared with arteries implanted with BMS (P<0.01). Histomorphometric analysis showed moderate inflammatory responses

such as infiltration of mononuclear cells

lymphocytes

and multinucleated giant cells in some arteries with SES compared with ZES (P<0.05). Injury scores were not different among the three groups at 30 and 90 days. The endothelialization score in the SES group was 2.69±0.42 at 30 days and 2.83±0.39 at 90 days compared with the ZES and BMS groups (both were 3.00±0.00 at either 30 or 90 days

P<0.05). Well developed endothelium was observed in the ZES group

while incomplete endothelium and inflammatory cells were observed with stent struts partly naked at the vessel lumen in the SES group. The ZES inhibits neointimal hyperplasia with good endothelia coverage in the porcine balloon injury coronary model.

Abstract

To examine the effect of the zedoary essential component-eluting stent (ZES) on a porcine coronary neointimal formation. ZES

sirolimus-eluting stents (SES)

and bare metal stents (BMS) were randomly implanted in three different major epicardial vessels in 36 balloon-injured pigs. Coronary angiography

optical coherence tomography

and histomorphological analysis were used to determine antihyperplasia effects. ZES and SES had a significantly larger lumen diameter and area

and reduced diameter and area of stenosis in arteries at 30 and 90 days compared with arteries implanted with BMS (P<0.01). Histomorphometric analysis showed moderate inflammatory responses

such as infiltration of mononuclear cells

lymphocytes

P<0.05). Well developed endothelium was observed in the ZES group

关键词

zedoary essential component-eluting stentrestenosisneointimalendothelialization

Keywords

zedoary essential component-eluting stentrestenosisneointimalendothelialization

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Beijing University of Chinese Medicine

National Integrative Medicine Center for Cardiovascular Diseases, China-Japan Friendship Hospital

Xiyuan Hospital, China Academy of Chinese Medical Sciences

Xiyuan Hospital, China Academy of TCM

The Third Hospital Affiliated to Peking University, Health Science Center

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