FOLLOWUS
How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?
- Chinese Journal of Integrative Medicine Vol. 19, Issue 11, Pages: 874-880(2013)
- Affiliations：
1. Department of Rheumatism Immunity, First Affiliated Hospital, Anhui University of Chinese Medicine,Hefei,China
2. Anhui University of Chinese Medicine,Hefei,China
- Author bio：
- Funds：Supported by the Key Projects in the National Science and Technology Pillar Program during the Twelfth Five-Year Plan Period (No. 2012BAI26B02);the National Key Disciplines of Chinese Medicine Construction Projects (No. [2009]30);Anhui Technology Scientific Research and Development Program of Provincial Department (No. 11010402170);Technology Innovation Team Program of Anhui University of Chinese Medicine (No. 2010TD005)
DOI：10.1007/s11655-013-1620-6
CLC：Published：2013，
Published Online：30 October 2013，
Scan for full text
Liu, J., Sun, Y. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?., Chin. J. Integr. Med. 19, 874–880 (2013). https://doi.org/10.1007/s11655-013-1620-6
Jian Liu, Yue Sun. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?. [J]. Chinese Journal of Integrative Medicine 19(11):874-880(2013)
Liu, J., Sun, Y. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?., Chin. J. Integr. Med. 19, 874–880 (2013). https://doi.org/10.1007/s11655-013-1620-6 DOI：
Jian Liu, Yue Sun. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis?. [J]. Chinese Journal of Integrative Medicine 19(11):874-880(2013) DOI： 10.1007/s11655-013-1620-6.
摘要
Rheumatoid arthritis (RA) manifests as an imbalance between pro- and anti-inflammatory cytokines. Cytokine imbalance is suggested to play critical roles in the development of RA. Currently
various treatments for RA
including biological agents such as antibodies against inflammation mediators
or Chinese herbal medicines
intervene the disease by restoring the balance of cytokines. Chinese medicine (CM) can not only suppress the expression of pro-inflammatory cytokines
but also induce the expression of cytokines with anti-inflammatory and immunomodulatory effects. Thus
Chinese medicine can effectively reduce inflammatory cell infiltration into synovial tissue
pannus formation
and degradation of the extracellular matrix surrounding cartilage cells
thereby reducing subchondral bone damage. This paper reviews the changes of cytokine profiling during development of RA and discuss the mechanisms by which Chinese medicine restores the cytokine balance.
Abstract
Rheumatoid arthritis (RA) manifests as an imbalance between pro- and anti-inflammatory cytokines. Cytokine imbalance is suggested to play critical roles in the development of RA. Currently
various treatments for RA
including biological agents such as antibodies against inflammation mediators
or Chinese herbal medicines
intervene the disease by restoring the balance of cytokines. Chinese medicine (CM) can not only suppress the expression of pro-inflammatory cytokines
but also induce the expression of cytokines with anti-inflammatory and immunomodulatory effects. Thus
Chinese medicine can effectively reduce inflammatory cell infiltration into synovial tissue
pannus formation
and degradation of the extracellular matrix surrounding cartilage cells
thereby reducing subchondral bone damage. This paper reviews the changes of cytokine profiling during development of RA and discuss the mechanisms by which Chinese medicine restores the cytokine balance.
关键词
rheumatoid arthritiscytokine imbalanceChinese Medicine
Keywords
rheumatoid arthritiscytokine imbalanceChinese Medicine
references
Ma WK, Yao XM, Tang F, Huang Y, Wang Y. On the correlation between “Yin Yang balance” and rheumatoid arthritis cytokine network regulation. Jiangsu J Tradit Chin Med (Chin) 2011;43(7):3–5.
Tian J, Lu WW, Ping LF. Research progress in the effect of Chinese medicine on cytokines in adjuvant arthritis rats. Modern J Integr Tradit Chin West Med (Chin) 2009;18:3774–3788.
Wang Y, Wang LW. Progress on immune cells and cytokines in the pathogenesis of rheumatoid arthritis. Chin J Rehabil Med (Chin) 2007;22:370–373.
El-Kady IM, El-Masry SA. Pro-inflammatory and antiinflammatory cytokines profile in rheumatoid arthritis patients. Egypt J Immunol 2008;15:109–114.
Cao YX, Liu J, Zhu Y. The influence of Xinfeng Capsule on the cardiac function and cytokines in adjuvant arthritis rats. Chin J Clin Health (Chin) 2010;13:503–506.
Skapenko A, Leipe J, Lipsky PE, et al. The role of the T cell in autoimmune inflammation. Arthritis Res Ther 2005;7:4–14.
Zhang H, Zhu P. Therapy for autoimmune diseases by acting on Th1/Th2 cytokine balance. Immunol J (Chin) 2000;16:119.
Kraan MC, Smeets TJ, van Loon MJ, Breedveld FC, Dijkmans BA, Tak PP. Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. Ann Rheum Dis 2004;63:1056–1061.
Kraan MC, Reece RJ, Barg EC, Smeets TJ, Farnell J, Rosenburg R, et al. Modulation of inflammation and metalloproteinase expression in synovial tissue by leflunomide and methotraxate in patients with active rheumatoid arthritis. Arthritis Rheum 2000;43:1820–1830.
Atzeni F, Turiel M, Capsoni F, Doria A, Meroni P, Sarzi-Puttini P. Autoimmunity and anti-TNF-alpha agents. Ann N Y Acad Sci 2005;1051:559–569.
Liu Z, Liu FQ. Clinical progress in the treatment of rheumatoid arthritis with immune cytokine based. J Chin Modern Med (Chin) 2004;1:136–140.
Young DA, Hegen M, Ma HL, Whitters MJ, Albert LM, Lowe L, et al. Blockade of the interleukin-21/interleukin-21 receptor pathway ameliorates disease in animal models of rheumatoid arthritis. Arthritis Rheum 2007;56:1152–1163.
Gu J, Han QY, Xue YJ, Liu LF, Liu D. Influence of Salvia miltiorrbiza on the serum matrix metalloprotenase-9 levels and the prethrombotic state of CII-induced rheumatoid arthritis in rats. J Med Rea (Chin) 2008;37:51–52.
Liu QS, Jiang H, Tang Z. Influence of Salvia miltiorrhiza on expression of tumor necrosis factor alpha of synovial cells in rheumatoid arthritis patients. Chin J Clin (Electronic Ed, Chin) 2009;3:1354–1358.
Li YJ, Li HL, Wu J. Regulatory effect of Fructus Corni on specific cellular immunity functions of adjuvant arthritis rats. Chin J Misdiagn (Chin) 2009;9:530–531.
Fu GX, Li JM, Zhou Y, Zhao SP. Anti-inflammatory and immune suppressive effects of Cornus officinalis glycosides in rats. Chin J Microbiol Immunol (Chin) 2007;27:316–320.
Zhu J, Xie WL, Jin YZ, Sun WJ, Gao X. Effect of Gardenia jasminoides Ellis on serum IL-1β and TNF-α of rheumatoid arthritis rats. Chin Tradit Patent Med (Chin) 2005;27:801–803.
Yao YY, Jiang LS, Chen MZ. Studies on the therapeutic effects of total flavonids of astragalus on Adjuvant arthritic rats and its mechanism. Chin Tradit Patent Med (Chin) 2001;23:661–663.
Liu J. Advances in studies on regulation effects on cytokines of rheumatoid arthritis by traditional Chinese medicine. J Anhui Tradit Chin Med Coll (Chin) 2002;21:55–59.
Zhou Q, Li ZG. Pharmaceutical effects of total glucosides of peony and its application in autoimmune disease. Chin J New Drugs Clin Remed (Chin) 2003;22:687–691.
Fang YF, Wang Y, Zhou X, Zhong B, Bo GP, Zhang C. Effect of sinomenine on cytokine expression by synoviocytes in a rat model of adjuvant arthritis. Herald Med (Chin) 2003;22:519–521.
Yu KQ, Lou R. Effect of sinomenine on the expression of chemokines and chemokine receptors in dendritic cells from patients with rheumatoid arthritis. J Southern Univ (Chin) 2009;29. 635–641.
Xu XY, Ye L, Chen G, Feng JD, Chen WH, Hu YY. Effects of tetramethylpyrazine on expression of vascular endothelial growth factor and hypoxia-induced factor-1α by rat peritoneal macrophages. China J Chin Mater Med (Chin) 2006;31:1608–1610.
Qun C, Wei W. Effects and mechanisms of glucosides of chaenomeles speciosa on collagen-induced arthritis in rats. Int Immunopharmacol 2003;3:593–608.
Lin N, Liu C, Xiao C, Jia H, Imada K, Wu H, et al. Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collage-induced arthritis mice. Biochem Pharmacol 2007;73:136–146.
Li T, Li YM, Liu LF, Wang YX, Li FW, Zhu XX. Mechanism of total saponins of Radix Clematidis on rheumatoid arthritis. J China Pharm Univ (Chin) 2009;40:157–160.
Miao B, Yang J, Zhou ZG, Bian XY, Yin LY. Effect of Herba Lycopodii extracts on rheumatoid factor and serum cytokines of adjuvant arthritis rats. Inf Tradit Chin Med (Chin) 2008;25:22–24.
Zhang CC, Pan L, Cui XJ. Effects of artesunate on the proliferation and expression of TNF-a and IL-1β in synoviocytes of collagen-induced arthritis rats. Guangdong Med J (Chin) 2009;30:1048–1049.
Bi J, Xin HL, Gao ZF, Lin WH, Qian RQ. Effect of kirenol on cytokines in serum and apoptosis proteins expression in synoviocytes of adjuvant arthritis rats. Chin Tradit Herbal Drugs (Chin) 2007;38:1207–1210.
Xing J, Wang S F. Antiinflammatory effect of traditional Chinese medicine and cytokines. Chin Tradit Herb Drugs (Chin) 2001;32:471–473.
Shen J, Bao JF, Zhang ZL, Ni LQ. The effects of Zaocys Dhumnades (Cantor) hydrolysate on the inflammatory cytokines and anti-inflammatory cytokines in the collageninduced arthritis (CIA). J Clin Intern Med (Chin) 2002;19:94.
Sha HJ. Treatment of erigeronits with leflunomide on RA and relationship between curative effect and IL-1β,TNF-α, ET-1, NO. Shijiazhuang: Hebei Med Univ;2004. Available at: http://epub.cnki.net/kns/brief/default_result.aspx
Fan L, Li L, He HF. Pharmacological studies on antiinflammatory and analgesic effects of Radix angelicae pubeascentis’s volatile oil. Anhui Med Pharm J (Chin) 2009;13:133–134.
Yuan LX. Effect of Dangguiniantong Tang and decomposition study on IL-1β and TNF-αof rheumatoid arthritis rat. Chin Archi Tradit Chin Med (Chin) 2008;6:1213–1214.
Liu WD, Shi XG, Kuang YQ, Zhao YT, Zeng WQ. Study on the effect on rheumatoid arthritis rats related cytokines by Wutou Decoction. J Chin Med Mater (Chin) 2009;8:1267–1269.
Sun ZX. Effect of Shentong Zhuyu Decoction on IL-1β,TNF-α and PGE2 in joint fluid of rats with adjuvant arthritis. Chin J Tradit Med Sci Technol (Chin) 2004;11:75–76.
Li BL, Tang F. Experimental research on Chinese herbal prescriptions to treat rheumatoid arthritis and their anti-inflammatory mechanism. Chin J Immunol (Chin) 2007;23:702–705.
Song CX. Influence of Xinsimiao Decoction on serum cytokine levels in rats with adjuvant arthritis. Guangming J Chin Med (Chin) 2007;22:48–51.
Shi XG, Zang SP, Xu ZD. Effect of Baihu Zhuifeng Wan on TNF-α by synoviocyte in adjuvant arthritis rats. Pharmacol Clin Chin Mater Med (Chin) 2000;16:4–6.
Jia HW, Zhao N, Zhang WD. Effects of Xuanfa Moyuan Recipe on serum levels of TNF-α, IFN-Γ, IL-6 and IL-10 in collagen-induced arthritis in rats. Chin J Basic Med Tradit Chin Med (Chin) 2005;11:818–820.
Liu J, Han MX, Liu XH, Zhuo XZ, Zhao LP. The effects of Xinfeng Capsule on the cytokins in the patients with rheumatoid arthritis. Chin J Clin Healthcare (Chin) 2004;7:11–14.
Liu J, Liu XH, Han MX. Treatment of 20 cases of rheumatoid arthritis in active stage with Xinfeng Capsule. J Anhui Tradit Chin Med Coll (Chin) 2003;3:12–16.
Liu W, Zhang L, Zhou YL, Liu XY. Influence of Biqi Capsule on cytokine in rheumatoid arthritis. Tianjing J Tradit Chin Med (Chin) 2005;22:290–291.
Chen JF, Zhao HF, Shen XY, Li SH, Li YM, Liao SH, et al. Effect of Tongbiling on synoviocytes secretion of IL-1, TNF-α and PGE2 in rats with adjuvant arthritis. J Guangzhou Univ Tradit Chin Med (Chin) 1999;16:31–33.
Liu CF, Duan FJ. Effect of infusion of Xuanbi Granule on Th1/Th2 equilibrium in adjuvant arthritis model rats. J Liaoning Univ Tradit Chin Med (Chin) 2008;10:27–29.
Tang Y, Chen DJ, Zhen YS. Theinfluence of Kunmingshanhaitang (KMSHT) Capsule on T lymphocyte of adjuvant arthritis rat. Chin J Tradit Med Traumatol Orthoped (Chin) 2004;7:7–9.
Sun SP, Zhou CY, Zhou HR, Chen YZ. Influence of Bisuqing Mixture on serum cytokine levels in rats with adjuvant arthritis. J Shandong Univ Tradit Chin Med (Chin) 2003;2:462–465.
Zhang LJ, Tang N, Chai LM, Huang XQ, Lin GB. Influences of Lijie Capsule on IL-2, IL-6 level and T lymphocyte apoptosis of adjuvant arthritis rats. Pharmacol Clin Chin Mater Med (Chin) 2005;21:58–59.
Wang WD, Zhou Y, Zhang L, Li YG, Ge DY, Wu Y. Effect of Bitongkang on immunofunction and cyctokine in mice. J Beijing Univ Tradit Chin Med (Chin) 2000;23:41–43.
Chang ZS, Wang YJ, Hu YQ. Observation on effect of Fengshian Granules on immune function of experimental rheumatoid arthritis rats. Chin J Basic Med Tradit Chin Med (Chin) 2000;6:29–31.
Zhou XP, Fang TH, Zhou LL, Song YH, Wang MY, Xu DQ. Study on the molecular mechanism of Qingluotongbi Granule in the treatment of rheumatoid arthritis. Pharmacol Clin Chin Mater Med (Chin) 2003;19:35–37.
0
Views
857
Downloads
11
CSCD
- Meta-XMLDownload
- BibTeXDownload
- EndnoteDownload
- RefMan Download
- NoteExpressDownload
- NoteFirstDownload
Publicity Resources
Related Articles
Related Author
Related Institution
- Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
- Tel：010-62886827, 62877592 Fax：010-62874291
- Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1
京公网安备11010802024621 - It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
- Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.
