The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis

Jia Guo; Ping Xue; Xiao-nan Yang; Zi-qi Lin; Yan Chen; Tao Jin; Wei Wu; Xu-bao Liu; Qing Xia

doi:10.1007/s11655-013-1653-x

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The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis

Updated：2021-08-27

- The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis
- Chinese Journal of Integrative Medicine Vol. 19, Issue 12, Pages: 913-917(2013)
- Affiliations：
  
  1. Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University,Chengdu,China
  2. Department of General Surgery, West China Hospital, Sichuan University,Chengdu,China
- Author bio：
- Funds：
  
  Supported by Science and Technology Support Program of Sichuan (No. 2011SZ0291, 2010SZ0068)
- DOI：10.1007/s11655-013-1653-x
  CLC：
- Published：2013，
  
  Published Online：5 December 2013，
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Guo, J., Xue, P., Yang, Xn. et al. The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis., Chin. J. Integr. Med. 19, 913–917 (2013). https://doi.org/10.1007/s11655-013-1653-x

Jia Guo, Ping Xue, Xiao-nan Yang, et al. The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis. [J]. Chinese Journal of Integrative Medicine 19(12):913-917(2013)
Guo, J., Xue, P., Yang, Xn. et al. The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis., Chin. J. Integr. Med. 19, 913–917 (2013). https://doi.org/10.1007/s11655-013-1653-x DOI：

Jia Guo, Ping Xue, Xiao-nan Yang, et al. The effect of Chaiqin Chengqi Decoction (柴芩承气汤) on modulating serum matrix metalloproteinase 9 in patients with severe acute pancreatitis. [J]. Chinese Journal of Integrative Medicine 19(12):913-917(2013) DOI： 10.1007/s11655-013-1653-x.

摘要

To investigate the effect of Chaiqin Chengqi Decoction (柴芩承气汤

CQCQD) on regulating serum matrix metalloproteinase 9 (MMP-9) in patients with severe acute pancreatitis (SAP). Thirty-five SAP patients hospitalized in West China Hospital from September 1

2008 to February 28

2009 were randomly assigned to two groups using a computer-derived random number sequence in a ratio of 1:1

treatment group (18 patients) and the placebo control group (17 patients). The patients in the treatment group were administered with CQCQD by gastric perfusion (50 mL/2 h) and retention enema (200 mL/6 h) for 7 days. The two groups had similar baseline information. The clinical indicators

including the initial Balthazar’s computed tomography (CT) score

acute physiology and chronic health evaluation II (APACHE II) scores on 1st

3rd

5th and 7th day

incidences and durations of complications and the serum C-reactive protein (CRP)

levels of MMP-9 on the 1st

3rd

5th and 7th day

were recorded and compared between the two groups. The serum MMP-9

CRP and the APACHE II scores on the 3rd

5th and 7th day in the treatment group were lower than those in the control group (P<0.05). The serum MMP-9 was positively correlated with the APACHE II score on the 1st day (r=0.430

P=0.01). The durations of acute respiratory distress syndrome (5.4±2.4 vs. 2.9±1.3)

acute hepatitis (4.6±0.8 vs. 1.9±0.6) and acute heart failure (3.9±1.6 vs. 1.3±0.6

<0.05) in the control group were longer than those in the treatment group. CQCQD could decrease the serum MMP-9 to relieve the severity of clinical symptoms and prevent the development of multiple organ dysfunction syndrome in patients with SAP.

Abstract

To investigate the effect of Chaiqin Chengqi Decoction (柴芩承气汤

CQCQD) on regulating serum matrix metalloproteinase 9 (MMP-9) in patients with severe acute pancreatitis (SAP). Thirty-five SAP patients hospitalized in West China Hospital from September 1

2008 to February 28

2009 were randomly assigned to two groups using a computer-derived random number sequence in a ratio of 1:1

including the initial Balthazar’s computed tomography (CT) score

acute physiology and chronic health evaluation II (APACHE II) scores on 1st

3rd

5th and 7th day

incidences and durations of complications and the serum C-reactive protein (CRP)

levels of MMP-9 on the 1st

3rd

5th and 7th day

were recorded and compared between the two groups. The serum MMP-9

CRP and the APACHE II scores on the 3rd

5th and 7th day in the treatment group were lower than those in the control group (P<0.05). The serum MMP-9 was positively correlated with the APACHE II score on the 1st day (r=0.430

P=0.01). The durations of acute respiratory distress syndrome (5.4±2.4 vs. 2.9±1.3)

acute hepatitis (4.6±0.8 vs. 1.9±0.6) and acute heart failure (3.9±1.6 vs. 1.3±0.6

关键词

severe acute pancreatitisSystemic Inflammatory Response Syndromematrix metalloproteinase-9Chaiqin Chengqi Decoction

Keywords

severe acute pancreatitisSystemic Inflammatory Response Syndromematrix metalloproteinase-9Chaiqin Chengqi Decoction

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Department of Integrated Chinese and Western Medicine, West China Hospital of Sichuan University

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