Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model

Hu-jun Wang; Wei-cheng Gao; Shao-lin Ma

doi:10.1007/s11655-014-1622-4

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Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model

Updated：2021-08-27

- Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model
- Chinese Journal of Integrative Medicine Vol. 21, Issue 7, Pages: 537-541(2015)
- Affiliations：
  
  Department of Plastic Surgery of the First Teaching Hospital, Xinjiang Medical University,Urumqi,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Xinjiang Uygur Autonomous Region of China (No. 2009211A16), and the National Natural Science Foundation of China (No. 81260291)
- DOI：10.1007/s11655-014-1622-4
  CLC：
- Published：2015，
  
  Published Online：21 January 2014，
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Wang, Hj., Gao, Wc. & Ma, Sl. Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model., Chin. J. Integr. Med. 21, 537–541 (2015). https://doi.org/10.1007/s11655-014-1622-4

Hu-jun Wang, Wei-cheng Gao, Shao-lin Ma. Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model. [J]. Chinese Journal of Integrative Medicine 21(7):537-541(2015)
Wang, Hj., Gao, Wc. & Ma, Sl. Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model., Chin. J. Integr. Med. 21, 537–541 (2015). https://doi.org/10.1007/s11655-014-1622-4 DOI：

Hu-jun Wang, Wei-cheng Gao, Shao-lin Ma. Effect of Abnormal Savda Munziq on hypertrophic scar formation in a rabbit ear model. [J]. Chinese Journal of Integrative Medicine 21(7):537-541(2015) DOI： 10.1007/s11655-014-1622-4.

摘要

To investigate whether administrating Abnormal Savda Munziq (ASMq)

a traditional Uighur herbal preparation used for the prevention or treatment of diseases

affects hypertrophic scar (HTS) formation by using an established rabbit ear model. The HTS rabbit model was created by circular fullthickness skin excisions on both ears of rabbits. Twenty rabbits were randomized into four groups

with 5 rabbits and 60 wounds in each group. Group A was the control group

treated with normal saline daily. Groups B

and D were the treatment groups at three different doses of ASMq (400

800

and 1200 mg/kg body weight

respectively

daily

by gastrogavage). Twenty wounds were randomly chosen from each group on the 40th day after treatment and specimen were examined. Scar elevation index (SEI) was analyzed with histological assessment

and ultrastructure analysis was analyzed with a transmission electron microscopy. Groups B

and D demonstrated significant reductions in SEI as compared with the control group at 35.9% (P=0.0212)

48.2% (P=0.0108)

and 52.7% (P=0.0103)

respectively in a dose-response manner. SEI was lowered in Group D compared with Group B with a significant difference (P=0.015). However

there were no significant differences between Groups B and C

or between Groups C and D. Histological analysis showed that highdose ASMq (1200 mg/kg) could enhance the softening of HTS of rabbit ears and increase the compliance as shown in general. Ultrastructure analysis showed that with increased ASMq dose

the fibroblasts

pro-collagen

collagen

endoplasmic reticulum and ribosomes were reduced gradually. Orally administered ASMq significantly reduces the severity of HTS in the rabbit ear model. The findings of this study may have clinical implications on the management of human HTS.

Abstract

To investigate whether administrating Abnormal Savda Munziq (ASMq)

a traditional Uighur herbal preparation used for the prevention or treatment of diseases

with 5 rabbits and 60 wounds in each group. Group A was the control group

treated with normal saline daily. Groups B

and D were the treatment groups at three different doses of ASMq (400

800

and 1200 mg/kg body weight

respectively

daily

by gastrogavage). Twenty wounds were randomly chosen from each group on the 40th day after treatment and specimen were examined. Scar elevation index (SEI) was analyzed with histological assessment

and ultrastructure analysis was analyzed with a transmission electron microscopy. Groups B

and D demonstrated significant reductions in SEI as compared with the control group at 35.9% (P=0.0212)

48.2% (P=0.0108)

and 52.7% (P=0.0103)

respectively in a dose-response manner. SEI was lowered in Group D compared with Group B with a significant difference (P=0.015). However

there were no significant differences between Groups B and C

the fibroblasts

pro-collagen

collagen

关键词

hypertrophic scarAbnormal Savda Munziqultrastructure

Keywords

hypertrophic scarAbnormal Savda Munziqultrastructure

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