Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction

Fan Xiong; Juan Gui; Wei Yang; Jing Li; Guang-ying Huang

doi:10.1007/s11655-014-1755-0

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Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction

Updated：2021-08-27

- Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction
- Chinese Journal of Integrative Medicine Vol. 21, Issue 1, Pages: 58-66(2015)
- Affiliations：
  
  1. Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
  2. Institute of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
  3. Institute of Reproductive Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,China
- Author bio：
- Funds：
  
  Supported by National Nature Science Foundation of China (No. S-049-09-10-20), and National Basic Research Program of China (973 Program, No. 2011CB505203)
- DOI：10.1007/s11655-014-1755-0
  CLC：
- Published：2015，
  
  Published Online：6 May 2014，
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Xiong, F., Gui, J., Yang, W. et al. Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction., Chin. J. Integr. Med. 21, 58–66 (2015). https://doi.org/10.1007/s11655-014-1755-0

Fan Xiong, Juan Gui, Wei Yang, et al. Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction. [J]. Chinese Journal of Integrative Medicine 21(1):58-66(2015)
Xiong, F., Gui, J., Yang, W. et al. Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction., Chin. J. Integr. Med. 21, 58–66 (2015). https://doi.org/10.1007/s11655-014-1755-0 DOI：

Fan Xiong, Juan Gui, Wei Yang, et al. Effects of acupuncture on progesterone and prolactin in rats of embryo implantation dysfunction. [J]. Chinese Journal of Integrative Medicine 21(1):58-66(2015) DOI： 10.1007/s11655-014-1755-0.

摘要

To investigate the effect of acupuncture on progesterone (P4) and prolactin (PRL) in rats of embryo implantation dysfunction (EID). On the first day of pregnancy

72 female Wistar rats were randomly allocated into the normal group

the EID model group

the acupuncture group and the P4 group (18 in each group). The normal group was injected sesame oil

while the other three groups were given mifepristone to establish the EID model. The acupuncture group and the P4 group were given treatment of acupuncture and P4 injection

respectively. The serum of P4 and PRL were detected by radioimmunoassay

and the mRNA and protein expressions of P4 receptor (PR) and PRL receptor (PRLR) were detected using real-time polymerase chain reaction and immunohistochemical method

respectively. Compared with the normal group

the serum levels of P4 and PRL as well as the mRNA and protein expression levels of PR and PRLR in the EID model group were significantly lowered (P<0.01 or P<0.05). The above indices in the acupuncture group and the P4 group were significantly elevated compared with the EID model group (P<0.01 or P<0.05). Acupuncture can promote embryo implantation effectively

which might be related to the effects of acupuncture on upregulating the P4 and PRL levels in serum and the PR and PRLR expression levels in rats.

Abstract

To investigate the effect of acupuncture on progesterone (P4) and prolactin (PRL) in rats of embryo implantation dysfunction (EID). On the first day of pregnancy

72 female Wistar rats were randomly allocated into the normal group

the EID model group

the acupuncture group and the P4 group (18 in each group). The normal group was injected sesame oil

while the other three groups were given mifepristone to establish the EID model. The acupuncture group and the P4 group were given treatment of acupuncture and P4 injection

respectively. The serum of P4 and PRL were detected by radioimmunoassay

and the mRNA and protein expressions of P4 receptor (PR) and PRL receptor (PRLR) were detected using real-time polymerase chain reaction and immunohistochemical method

respectively. Compared with the normal group

which might be related to the effects of acupuncture on upregulating the P4 and PRL levels in serum and the PR and PRLR expression levels in rats.

关键词

acupunctureProgesteroneProlactinprogesterone receptorprolactin receptorembryo implantation dysfunction

Keywords

acupunctureProgesteroneProlactinprogesterone receptorprolactin receptorembryo implantation dysfunction

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Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University

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Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

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