A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis

Shi-chao Lu; Jun-ping Zhang; Ya-ping Zhu; Ya-nan Zhou; Nan Xiao; Xiao-chen Guo; Xiao-ling Wang; Jie Rong; Mei-fang Wu

doi:10.1007/s11655-014-1815-5

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A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis

Updated：2021-08-27

- A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis
- Chinese Journal of Integrative Medicine Vol. 21, Issue 3, Pages: 176-182(2015)
- Affiliations：
  
  1. Tianjin University of Traditional Chinese Medicine,Tianjin,China
  2. First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the 11th Five-year Plan National Science and Technology Support Program (No. 2007BAI20B073)
- DOI：10.1007/s11655-014-1815-5
  CLC：
- Published：2015，
  
  Published Online：23 May 2014，
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Lu, Sc., Zhang, Jp., Zhu, Yp. et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis., Chin. J. Integr. Med. 21, 176–182 (2015). https://doi.org/10.1007/s11655-014-1815-5

Shi-chao Lu, Jun-ping Zhang, Ya-ping Zhu, et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis. [J]. Chinese Journal of Integrative Medicine 21(3):176-182(2015)
Lu, Sc., Zhang, Jp., Zhu, Yp. et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis., Chin. J. Integr. Med. 21, 176–182 (2015). https://doi.org/10.1007/s11655-014-1815-5 DOI：

Shi-chao Lu, Jun-ping Zhang, Ya-ping Zhu, et al. A randomized clinical study on optimum proposal of integration of disease and syndrome to treat viral myocarditis. [J]. Chinese Journal of Integrative Medicine 21(3):176-182(2015) DOI： 10.1007/s11655-014-1815-5.

摘要

To determine the optimum treatment for viral myocarditis (VMC). A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine

and the intervention group (84 cases) that was treated with a combination of Chinese medicine (CM) and Western medicine intervention termed optimum proposal of integration of disease and syndrome (OPIDS). Before and after 4 weeks of treatment

the integral of CM syndrome

self-rating depression and anxiety scales (SDS and SAS

respectively)

echocardiograms (ECGs)

heart rate variability and left ventricular systolic function were observed. Compared with the control group

the intervention group showed significant reductions on the SDS and SAS (P <0.05); improvement of premature ventricular beats

atrioventricular blocks

ST-segment abnormalities

and significant T wave changes (P <0.05); greater reductions in standard deviation of NN intervals (SDNN)

standard deviation for per 5 min averages NN intervals (SDANN)

and root-mean-square of successive difference of NN intervals (rMSSD) (P <0.05); and increases in cardiac output

stroke volume

and ejection fraction

the last of which was statistically significant (P <0.05). Overall

the treatment efficacy rate was significantly better P<0.05) in the intervention group (75.61%) compared with the control group (69.70%). OPIDS is quite effective in treating VMC and improves symptoms such as anxiety and depression

left ventricular systolic dysfunction

premature ventricular contraction

and cardiac autonomic nervous system dysfunction. [Registration: Chinese clinical trial center (No. ChiCTR-TRC-00000298)]

Abstract

To determine the optimum treatment for viral myocarditis (VMC). A total of 126 VMC patients were randomly divided into the control group (42 cases) that was treated with conventional Western medicine

the integral of CM syndrome

self-rating depression and anxiety scales (SDS and SAS

respectively)

echocardiograms (ECGs)

heart rate variability and left ventricular systolic function were observed. Compared with the control group

the intervention group showed significant reductions on the SDS and SAS (P <0.05); improvement of premature ventricular beats

atrioventricular blocks

ST-segment abnormalities

and significant T wave changes (P <0.05); greater reductions in standard deviation of NN intervals (SDNN)

standard deviation for per 5 min averages NN intervals (SDANN)

and root-mean-square of successive difference of NN intervals (rMSSD) (P <0.05); and increases in cardiac output

stroke volume

and ejection fraction

the last of which was statistically significant (P <0.05). Overall

left ventricular systolic dysfunction

premature ventricular contraction

and cardiac autonomic nervous system dysfunction. [Registration: Chinese clinical trial center (No. ChiCTR-TRC-00000298)]

关键词

Viral MyocarditisChinese Medicinerandomized clinical trial

Keywords

Viral MyocarditisChinese Medicinerandomized clinical trial

references

Chen HZ, Fan WH, Jin XJ, Wang Q, Zhou J, Shi ZY. Changing trends of etiologic characteristics of cardiovascular diseases among inpatients in Shanghai: a retrospective observational study from 1948 to 1999. Chin J Intern Med (Chin) 2003;42:829–832.

Group on the Countermeasures of Myocarditis and Cardiomyopathy of Editorial Committee of Chinese Journal of Cardiology. About the diagnostic reference standard of adult acute viral myocarditis and adopt the suggestion for definition and classification of cardiomyopathy from the World Health Organization and the International Federation of Society of Cardiology Working Group. Chin J Cardiol (Chin) 1999;27:405–407.

Guiding principle of clinical research on new drugs of Chinese medicine. Beijing: Ministry of Health of the People’s Republic of China; 1993:46–51.

Chen HZ. Practice of internal medicine. 12th ed. Beijing: People’s Medical Publishing House; 2005:1575.

Administration criterion of decocting Chinese medicine room in medical institutions. Beijing: Ministry of Health of the People’s Republic of China; 2009:29–31.

Wang BQ, Yin ZJ. Analysis of major factors which affects myocardial fibrosis. Guide China Med (Chin) 2010;8:36–37.

He JC, Pu BH. The advancement of fundamental Experiment Study of Chinese medicine treatment of viral myocarditis. Liaoning J Tradit Chin Med (Chin) 2008;35:1109–1112.

Sun CW, Zhong GG, Jiang Y. Study on antioxidant effect of Astragalus polysaccharide. Chin Pharmacol Bulletin (Chin) 1996;12:161–163.

Liu GX, Gu QB. Effects of astragalus membranaceus on L type calcium channel and Na+/Ca2+ exchange in adult rat cardiomyocytes infected with coxsackie virus B3. Chin J Pathophysiol (Chin) 1999;15:591–593.

Peng L, Zhang JQ. Comment on integration of disease and syndrome as well as the conb of prescriptions and syndrome are the cornerstone of syndrome differentiation and treatment. J New Chin Med (Chin) 2009;41:1–2.

Chen KJ, Song J. Clinical study by way of combining diseases with differentiation of their syndromes, an important mode in study on combination of Chinese traditional and Western medicine. World Sci Technol-Modern Tradit Chin Med (Chin) 2006;8:1–5.

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