Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion

Bai-yan Liu; Xiao-ling Song; Jian Yi; Xue-mei Chen; Yue Yu; Hui Liu; Guang-xian Cai

doi:10.1007/s11655-014-1823-5

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Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion

Updated：2021-08-27

- Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion
- Chinese Journal of Integrative Medicine Vol. 20, Issue 10, Pages: 782-786(2014)
- Affiliations：
  
  Key Laboratory of Internal Medicine, Hunan University of Traditional Chinese Medicine,Changsha,China
- Author bio：
- Funds：
  
  Supported by National Natural Science Foundation of China (No. 30300470, 30472217, 30873355, and 81273989), Ministry Education of China (No. 209087), and Foundation of Educational Commission of Hunan Province (No. 08A049)
- DOI：10.1007/s11655-014-1823-5
  CLC：
- Published：2014，
  
  Published Online：7 August 2014，
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Liu, By., Song, Xl., Yi, J. et al. Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion., Chin. J. Integr. Med. 20, 782–786 (2014). https://doi.org/10.1007/s11655-014-1823-5

Bai-yan Liu, Xiao-ling Song, Jian Yi, et al. Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion. [J]. Chinese Journal of Integrative Medicine 20(10):782-786(2014)
Liu, By., Song, Xl., Yi, J. et al. Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion., Chin. J. Integr. Med. 20, 782–786 (2014). https://doi.org/10.1007/s11655-014-1823-5 DOI：

Bai-yan Liu, Xiao-ling Song, Jian Yi, et al. Buyang Huanwu Decoction (补阳还五汤) reduces infarct volume and enhances estradiol and estradiol receptor concentration in ovariectomized rats after middle cerebral artery occlusion. [J]. Chinese Journal of Integrative Medicine 20(10):782-786(2014) DOI： 10.1007/s11655-014-1823-5.

摘要

To investigate the effect of Buyang Huanwu Decoction (补阳还五汤

BYHWD) on estradiol (E2) and estradiol receptor (ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion (MCAO). Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO. Rats were randomly divided into normal

ovariectomy (OVX)

MCAO

OVX+MCAO

OVX+MCAO+E2

and OVX+MCAO+BYHWD group. Rats were administered BYHWD 5 g/kg daily

estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days. Neuronal function and infarct volume were measured on day 7 after artery occlusion

and E2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay. BYHWD significantly improved the neurological behavior

reduced the infarction volume

increased E2 concentration in serum and brain

and increased ER concentration in the brain in ovariectomized rats after MCAO. The neuroprotective effects of BYHWD are associated with estrogen and its receptor.

Abstract

To investigate the effect of Buyang Huanwu Decoction (补阳还五汤

ovariectomy (OVX)

MCAO

OVX+MCAO

OVX+MCAO+E2

and OVX+MCAO+BYHWD group. Rats were administered BYHWD 5 g/kg daily

estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days. Neuronal function and infarct volume were measured on day 7 after artery occlusion

and E2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay. BYHWD significantly improved the neurological behavior

reduced the infarction volume

increased E2 concentration in serum and brain

and increased ER concentration in the brain in ovariectomized rats after MCAO. The neuroprotective effects of BYHWD are associated with estrogen and its receptor.

关键词

Buyang Huanwu Decoctionfocal cerebral ischemicestrogenestrogen receptorChinese Medicine

Keywords

Buyang Huanwu Decoctionfocal cerebral ischemicestrogenestrogen receptorChinese Medicine

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