The contribution of deer velvet antler research to the modern biological medicine

Yu-shu Huo; Hong Huo; Jie Zhang

doi:10.1007/s11655-014-1827-1

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The contribution of deer velvet antler research to the modern biological medicine

Updated：2021-08-27

- The contribution of deer velvet antler research to the modern biological medicine
- Chinese Journal of Integrative Medicine Vol. 20, Issue 10, Pages: 723-728(2014)
- Affiliations：
  
  1. The University of Texas Health Science Center at San Anonio,San Antonio,USA
  2. No.1810, Dalian Chemical and Physical Institure of Chinese Academy of Sciencce Dalian,Liaoning Province,China
  3. Key Lab of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences,Fujian Province,Xiamen,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1827-1
  CLC：
- Published：2014，
  
  Published Online：16 October 2014，
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Huo, Ys., Huo, H. & Zhang, J. The contribution of deer velvet antler research to the modern biological medicine., Chin. J. Integr. Med. 20, 723–728 (2014). https://doi.org/10.1007/s11655-014-1827-1

Yu-shu Huo, Hong Huo, Jie Zhang. The contribution of deer velvet antler research to the modern biological medicine. [J]. Chinese Journal of Integrative Medicine 20(10):723-728(2014)
Huo, Ys., Huo, H. & Zhang, J. The contribution of deer velvet antler research to the modern biological medicine., Chin. J. Integr. Med. 20, 723–728 (2014). https://doi.org/10.1007/s11655-014-1827-1 DOI：

Yu-shu Huo, Hong Huo, Jie Zhang. The contribution of deer velvet antler research to the modern biological medicine. [J]. Chinese Journal of Integrative Medicine 20(10):723-728(2014) DOI： 10.1007/s11655-014-1827-1.

摘要

Deer velvet antler is the only mammal organ which can continuous regenerate. Currently

international scholars are interested in antler that is defined as a perfect regeneration model of neuro

blood vessel

connective tissue

cartilage

and bones. In 1986

we started to study the separation of active protein and peptide of fresh velvet antler using classic biochemical methods. After entering the 21st century

we further investigated the differentiation of antler proteome from different growth periods using advance differential proteomics approach

and unveiled the correlation between the proteome difference and life cycle. The international antler research has entered the stage of molecular biology

and will no doubt have a profound impact on the modern biomedical fields

such as regenerative medicine

organ degeneration and dysplasia

trauma medicine and anti-inflammatory treatment

growth factor research

as well as creation of new medical thinking.

Abstract

Deer velvet antler is the only mammal organ which can continuous regenerate. Currently

international scholars are interested in antler that is defined as a perfect regeneration model of neuro

blood vessel

connective tissue

cartilage

and bones. In 1986

we started to study the separation of active protein and peptide of fresh velvet antler using classic biochemical methods. After entering the 21st century

we further investigated the differentiation of antler proteome from different growth periods using advance differential proteomics approach

and unveiled the correlation between the proteome difference and life cycle. The international antler research has entered the stage of molecular biology

and will no doubt have a profound impact on the modern biomedical fields

such as regenerative medicine

organ degeneration and dysplasia

trauma medicine and anti-inflammatory treatment

growth factor research

as well as creation of new medical thinking.

关键词

deer antlerregenerateChinese Medicineproteomics

Keywords

deer antlerregenerateChinese Medicineproteomics

references

Faucheux C, Nesbitt SA, Horton MA, Price JS. Cells in regenerating deer antler cartilage provide a microenvironment that supports osteoclast differentiation. J Exp Biol 2001;204(Pt 3):443–455.

Li C, Suttie JM. Deer antlerogenic periosteum: a piece of postnatally retained embryonic tissue?. Anat Embryol (Berlin) 2001;204:375–388.

Goss RJ. Inhibition of growth and shedding of antlers by sex hormones. Nature 1968;220:83–85.

Goss RJ, ed. Deer antlers: regeneration, function, and evolution. New York: Academic Press; 1983.

Goss RJ. Future directions in antler research. Anatomical Record 1995;241:291–302.

Gray C, Hukkanen M, Konttinen YT, Terenghi G, Arnett TR, Jones SJ, et al. Rapid neural growth: calcitonin generelated peptide and substance P-containing nerves attain exceptional growth rates in regenerating deer antler. Neuroscience 1992;50:953–963.

Price JS, Oyajobi BO, Oreffo ROC, Russel RGG. Cells cultured from the growing tip of red deer antler express alkaline phosphatase and proliferate in response to insulinlike growth factor. J Endocrinol 1994;143:R9–R16.

Korbling M, Estrov Z. Adult stem cells for tissue repair—a new therapeutic concept?. New Engl J Med 2003;349:570–582.

Rosenthal N. Prometheus’s vulture and the stem-cell promise. New Engl J Med 2003;349:267–274.

Colitti M, Allen SP, Price JS. Programmed cell death in the regenerating deer antler. J Anat 2005;207:339–351.

Harty M, Neff AW, King MW, Mescher AL. Regeneration or scarring: an immunologic perspective. Devl Dynam 2003;226:268–279.

Francis SM, Suttie JM. Detection of growth factors and proto-oncogene mRNA in the growing tip of red deer (Cervus elaphus) antler using reverse-transcriptase polymerase chain reaction (RT-PCR). J Exp Zool 1998;28:36–42.

Barrell GK, Davies R, Bailey CI. Immunocytochemical localization of oestrogen receptors in perichondrium of antlers in red deer (Cervus elaphus). Reprod Fertil Devel 1999;11:189–192.

Faucheux C, Horton MA, Price JS. Nuclear localization of type I parathyroid hormone/parathyroid hormone-related protein receptors in deer antler osteoclasts: evidence for parathyroid hormone-related protein and receptor activator of NF-kappaB-dependent effects on osteoclast formation in regenerating mammalian bone. J Bone Miner Res 2002;17:455–464.

Allen SP, Maden M, Price JS. A role for retinoic acid in regulating the regeneration of deer antlers. Dev Biol 2002;251:409–423.

Price JS, Oyajobi BO, Nalin AM, Frazer A, Russell RGG, Sandell LJ. Chondrogenesis in the regenerating antler tip of red deer: Collagen types I, IIA, IIB and X expression demonstrated by in situ nucleic acid hybridisation and immunocytochemistry. Dev Dynamics 1996;203:332–347

Szuwart T, Kierdorf H, Kierdorf U, Clemen G. Ultrastructural aspects of cartilage formation, mineralization and degeneration during primary antler growth in fallow deer. Anat Anz 1998;180:501–510.

Chris Tuckwell (2003). Velvet antler a summary of the literature on health benefits. http://www.rirdc.gov.au/reports/DEE/03-084.pdf

Park HJ, Lee1 DH, Park SG, Lee SC, Cho S, Kim HK, et al. Proteome analysis of red deer antlers. Proteomics 2004;4:3642–3653.

Huo Y, Schirf VR, Winters WD. The differential expression of NGFS-like substance from fresh pilose antler of Cervus Nippon Temminck. Biomed Sci Instrum 1997;33:541–543.

Huo YS, Huo H. The differential expression of nerve growth factors from fresh poilose antler. Tradit Chin Drug Res Clin Pharm (Chin) 1997;8(2):79–81.

Wang F, Mei ZQ, Zhong QL, Wang BX. Antler deer peptide analysis and pharmacology. J Jilin Univ (Sci ed., Chin) 2003;41:111–114.

Zhao WH, Huang DQ, Hao DM, Li XJ, Liu XT, Wang BX. Clinidal investigation on how the injection hairy deerhorn auxin cryes the kidney positive form of the osteoporosis. Chin J Tradit Med Trauma Orthop (Chin) 2003;2(11):20–22.

Zheng HX, Ren YL, Du S, Lin ZR, Huo YS. Comparatively of freeze-drying velvet antler derr and heating driying research on osteoporosis model by emasculated rats. Chin Arch Tradit Chin Med (Chin) 2004;22:616–618.

Lin DY, Huang XN, Ke LJ, Chen XC, Ye XY, Huo YS, et al. Purification and characterization of the proliferation of rat osteoblast-like cells UMR-106 from Pilose Antler. China J Mater Med (Chin) 2005;30:851–855.

Zheng HX, Du S, Huo YS. Serum pharmacology research of feeding mouse by powder of freeze-drying velvet antler derr. In: Memoir of HUO Yu-hu. Jilin: Jilin Science Technical Publishing Company; 2014 Vol.2.

Gao L, Qiao XL, Liang Z, Zhang LH, Huo YS Zhang YK. Application of online two dimensional liquid chromatography in comatative roteome analysis of antlers with different growing stages. Chin J Chromatography (Chin) 2010;28:146–151.

Qu YY, Gao L, Liang Z, Zhang LH, Huo YS, Zhang YK. Extract methods research of protein from velvet antler deer. Report at 17th Chlomatography. Changsha, 2010:511–512.

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Beijing University of Chinese Medicine

The Second Clinical Medical College, Zhejiang Chinese Medical University

Department of Ortopaedics and Traumatology, the Second Affiliated Hospital of Zhejiang Chinese Medical University

Department of Diagnostics of Traditional Chinese Medicine, College of Basic Medical Science, Zhejiang Chinese Medical University

Georg-August-Universität Göttingen, Göttingen

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