FOLLOWUS
Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease
- Chinese Journal of Integrative Medicine Vol. 20, Issue 5, Pages: 341-346(2014)
- Affiliations：
1. Graduate School, Beijing University of Chinese Medicine,Beijing,China
2. Center for Cardiovascular Diseases, Xiyuan Hospital, China Academy of Chinese Medical Sciences,Beijing,China
- Author bio：
- Funds：Supported by Beijing Committee of Science and Technology (No. D08050703020801), the Traditional Chinese Medicine Public Welfare Scientific Research Project, State Administration of Traditional Chinese Medicine of People’s Republic of China (No. 201007001), Natural Science Foundation of China (No. 30973702, 81373823, 81030063), and National Major Project for Fundamental Research and Development (No. 2006CB504803);Contribute equally to this paper
DOI：10.1007/s11655-014-1831-5
CLC：Published：2014，
Published Online：6 March 2014，
Scan for full text
Jiao, Y., Li, Sw., Shang, Qh. et al. Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease., Chin. J. Integr. Med. 20, 341–346 (2014). https://doi.org/10.1007/s11655-014-1831-5
Yang Jiao, Si-wei Li, Qing-hua Shang, et al. Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease. [J]. Chinese Journal of Integrative Medicine 20(5):341-346(2014)
Jiao, Y., Li, Sw., Shang, Qh. et al. Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease., Chin. J. Integr. Med. 20, 341–346 (2014). https://doi.org/10.1007/s11655-014-1831-5 DOI：
Yang Jiao, Si-wei Li, Qing-hua Shang, et al. Multifactor dimensionality reduction analysis of the correlation of Chinese medicine syndrome evolvement and cardiovascular events in patients with stable coronary heart disease. [J]. Chinese Journal of Integrative Medicine 20(5):341-346(2014) DOI： 10.1007/s11655-014-1831-5.
摘要
To analyze the correlation of Chinese medicine syndrome evolvement and cardiovascular: events in patients with stable coronary heart disease (CHD). This prospective cohort study investigated and: collected the clinical information of patients with stable CHD and observed the syndrome type at the baseline and 6-month at follow-up
as well as the cardiovascular events during the 6-month and 12-month follow-up. The patients were divided into the event group and the non-event group. The interaction and the impact of syndrome evolvement on cardiovascular events were examined through multifactor dimensionality reduction (MDR) analysis and the results were verified by Chi-square test. Totally 1
333 of 1
503 stable CHD patients enrolled met the inclusion criteria: of MDR analysis. Among them
959 (71.9%) cases were males and 374 (28.1%) cases were females. Thirty seven cases had cardiovascular events during 6 to 12 months after the study began. The results of the MDR analysis and verification using Chi-square test showed that the development of cardiovascular events was positively correlated with interaction between blood stasis and toxic syndrome at the baseline
blood stasis at the baseline and qi deficiency at the 6-month follow-up
toxic syndrome at the baseline and qi deficiency at the 6-month follow-up
toxic syndrome at the base line and blood stasis at the 6-month follow-up
qi deficiency and blood stasis at the 6-month follow-up (P<0.05 for all). Blood stasis
toxic syndrome and qi deficiency are important factors of stable CHD. There: are positive correlation between cardiovascular events and syndrome evolution from blood stasis to qi deficiency
from toxic syndrome to qi deficiency and from toxic syndrome to blood stasis
indicating the pathogenesis of toxin consuming qi
toxin leading to blood-stasis in stable CHD patients prone to recurrent cardiovascular events.
Abstract
To analyze the correlation of Chinese medicine syndrome evolvement and cardiovascular: events in patients with stable coronary heart disease (CHD). This prospective cohort study investigated and: collected the clinical information of patients with stable CHD and observed the syndrome type at the baseline and 6-month at follow-up
as well as the cardiovascular events during the 6-month and 12-month follow-up. The patients were divided into the event group and the non-event group. The interaction and the impact of syndrome evolvement on cardiovascular events were examined through multifactor dimensionality reduction (MDR) analysis and the results were verified by Chi-square test. Totally 1
333 of 1
503 stable CHD patients enrolled met the inclusion criteria: of MDR analysis. Among them
959 (71.9%) cases were males and 374 (28.1%) cases were females. Thirty seven cases had cardiovascular events during 6 to 12 months after the study began. The results of the MDR analysis and verification using Chi-square test showed that the development of cardiovascular events was positively correlated with interaction between blood stasis and toxic syndrome at the baseline
blood stasis at the baseline and qi deficiency at the 6-month follow-up
toxic syndrome at the baseline and qi deficiency at the 6-month follow-up
toxic syndrome at the base line and blood stasis at the 6-month follow-up
qi deficiency and blood stasis at the 6-month follow-up (P<0.05 for all). Blood stasis
toxic syndrome and qi deficiency are important factors of stable CHD. There: are positive correlation between cardiovascular events and syndrome evolution from blood stasis to qi deficiency
from toxic syndrome to qi deficiency and from toxic syndrome to blood stasis
indicating the pathogenesis of toxin consuming qi
toxin leading to blood-stasis in stable CHD patients prone to recurrent cardiovascular events.
关键词
stable coronary heart diseasecardiovascular eventssyndrome evolvementpathogenesis characteristics
Keywords
stable coronary heart diseasecardiovascular eventssyndrome evolvementpathogenesis characteristics
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