The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine

Jian-yun Wang; Xin-yue Wang; Hua-yang Wu; Hui-yi Sun; Da-ming Liu; Wen Zhang; Chen-xi Jin; Shuo-ren Wang

doi:10.1007/s11655-014-1842-2

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The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine

Updated：2021-08-27

- The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine
- Chinese Journal of Integrative Medicine Vol. 22, Issue 12, Pages: 894-901(2016)
- Affiliations：
  
  1. Department of Gastroenterology, the Third Hospital Affiliated to Beijing University of Chinese Medicine,Beijing,China
  2. Department of Gastroenterology, Dongzhimen Hospital,Beijing,China
  3. Department of Respiratory, Dongzhimen Hospital,Beijing,China
  4. Lung Function Laboratory, Dongzhimen Hospital,Beijing,China
  5. Deparment of Vasculocardiology, Dongzhimen Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Basic Research Program, Ministry of Science and Technology, China (No. 2009CB522705)
- DOI：10.1007/s11655-014-1842-2
  CLC：
- Published：2016，
  
  Published Online：18 June 2014，
Scan for full text
Wang, Jy., Wang, Xy., Wu, Hy. et al. The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine., Chin. J. Integr. Med. 22, 894–901 (2016). https://doi.org/10.1007/s11655-014-1842-2

Jian-yun Wang, Xin-yue Wang, Hua-yang Wu, et al. The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine. [J]. Chinese Journal of Integrative Medicine 22(12):894-901(2016)
Wang, Jy., Wang, Xy., Wu, Hy. et al. The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine., Chin. J. Integr. Med. 22, 894–901 (2016). https://doi.org/10.1007/s11655-014-1842-2 DOI：

Jian-yun Wang, Xin-yue Wang, Hua-yang Wu, et al. The association between pulmonary function impairment and colon inflammation in ulcerative colitis patients: A scientific basis for exterior-interior correlation between lung and large intestine. [J]. Chinese Journal of Integrative Medicine 22(12):894-901(2016) DOI： 10.1007/s11655-014-1842-2.

摘要

To investigated the involvement of pulmonary function impairment in ulcerative colitis (UC)

to explore a scientific basis for the Chinese medicine (CM) theory of exterior-interior correlation between Lung (Fei) and Large intestine (Dachang). Totally 120 patients with a diagnosis of UC were recruited and the demographics

clinical data

and blood samples were collected. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) concentrations were measured. Every patient accepted pulmonary function test and took chest radiograph (CXR).> Pulmonary function abnormalities were present in 72 of 120 patients. The median (interquartile range) vital capacity (VC)

forced vital capacity (FVC)

forced expiratory volume in 1 s (FEV1)

carbon monoxide diffusion capacity (DLCO) of lung

total lung capacity (TLC) and functional residual volume (FRV) were decreased in distal UC and pancolitis compared with ulcerative prochitis (P <0.0005). Male patients had increased VC

FEV1/FVC

and residual volume (RV)/TLC compared with female (P <0.0005)

but decreased DLCO and carbon monoxide iffusion capacity (KCO) of lung/alveolar ventilation (P <0.0005). Age was strongly correlated with RV (Spearman rank correlation coefficient (rs)=−0.57

P <0.0001)

and RV/TLC (rs=0.48

P<0.0001). Age was also correlated with FEV1/FVC (rs=−0.29

P=0.001)

forced expiratory flow in 75% vital capacity (FEF75%

rs=−0.20

P=0.03)

DLCO (rs=−0.21

P=0.02)

TLC (rs=−0.25

P=0.006)

and FRV (rs=−0.28

P=0.002). The course of disease was correlated with FEF75% (rs=−0.18

P=0.049) and KCO (rs=−0.19

P=0.036). Chest radiograph abnormalities were presented in 38 of 120. Pulmonary symptoms were presented in 10 of 120. Other extraintestinal complications were presented in 21 of 120. Pulmonary function impairment was more frequently than other extraintestinal complications in UC patients

which may be affected by sex

age

extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.

Abstract

To investigated the involvement of pulmonary function impairment in ulcerative colitis (UC)

clinical data

forced vital capacity (FVC)

forced expiratory volume in 1 s (FEV1)

carbon monoxide diffusion capacity (DLCO) of lung

total lung capacity (TLC) and functional residual volume (FRV) were decreased in distal UC and pancolitis compared with ulcerative prochitis (P <0.0005). Male patients had increased VC

FEV1/FVC

and residual volume (RV)/TLC compared with female (P <0.0005)

but decreased DLCO and carbon monoxide iffusion capacity (KCO) of lung/alveolar ventilation (P <0.0005). Age was strongly correlated with RV (Spearman rank correlation coefficient (rs)=−0.57

P <0.0001)

and RV/TLC (rs=0.48

P<0.0001). Age was also correlated with FEV1/FVC (rs=−0.29

P=0.001)

forced expiratory flow in 75% vital capacity (FEF75%

rs=−0.20

P=0.03)

DLCO (rs=−0.21

P=0.02)

TLC (rs=−0.25

P=0.006)

and FRV (rs=−0.28

P=0.002). The course of disease was correlated with FEF75% (rs=−0.18

P=0.049) and KCO (rs=−0.19

which may be affected by sex

age

extent and course of disease. These results may be a scientific basis for the theory of exterior-interior correlation between Lung and Large intestine.

关键词

pulmonary function impairmentUlcerative Colitisexterior-interior relationship between Lung and the Large intestineChinese Medicine

Keywords

pulmonary function impairmentUlcerative Colitisexterior-interior relationship between Lung and the Large intestineChinese Medicine

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