Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Chang-ming Chen; Li-zhu Lin; En-xin Zhang

doi:10.1007/s11655-014-1864-9

Your Location：

Home >

Browse articles >

Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study

Updated：2021-08-27

- Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study
- Chinese Journal of Integrative Medicine Vol. 20, Issue 7, Pages: 496-502(2014)
- Affiliations：
  
  Department of Oncology, First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1864-9
  CLC：
- Published：2014，
  
  Published Online：28 June 2014，
Scan for full text
Chen, Cm., Lin, Lz. & Zhang, Ex. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study., Chin. J. Integr. Med. 20, 496–502 (2014). https://doi.org/10.1007/s11655-014-1864-9

Chang-ming Chen, Li-zhu Lin, En-xin Zhang. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study. [J]. Chinese Journal of Integrative Medicine 20(7):496-502(2014)
Chen, Cm., Lin, Lz. & Zhang, Ex. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study., Chin. J. Integr. Med. 20, 496–502 (2014). https://doi.org/10.1007/s11655-014-1864-9 DOI：

Chang-ming Chen, Li-zhu Lin, En-xin Zhang. Standardized treatment of chinese medicine decoction for cancer pain patients with opioid-induced constipation: A multi-center prospective randomized controlled study. [J]. Chinese Journal of Integrative Medicine 20(7):496-502(2014) DOI： 10.1007/s11655-014-1864-9.

摘要

To observe the efficacy and the influence on quality of life (QOL) of syndrome differentiation treatment with Chinese medicine (CM) for opioid-induced constipation as well as the safety and influence on analgesic effect of opioids. Totally 406 cases enrolled from 53 collaborating medical centers were randomly assigned to a CM group and a control group. The CM group were treated with CM decoction based on syndrome differentiation

and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score (CCS)

numerical rating scale (NRS) of pain and Chinese version of European Organisation for Research and Treatment of Cancer

Quality of Life Questionnaire-C30 V3.0 (EORTC QLQ-C30 V3.0) were used to evaluate the efficacy

pain controlled and QOL status. The comparisons of CCS score reduction and QOL between the two groups after treatment suggested that the improvements of constipation and QOL in the CM group were better than that in the control group (P<0.05). The total efficiency of the CM group was better than the control group (93.5% vs. 86.4%

P<0.05). There was no significant difference in NRS scores between before and after treatment in both groups. There was no serious drug-related adverse event during the course of study. CM decoction could effectively treat opioid-induced constipation and improve patients’ QOL at the same time. It is safe and doesn’t affect the analgesic effect of opioids when treating constipation.

Abstract

and the control group were treated with Phenolphthalein Tablet. Both groups were treated for 14 days. Cleveland constipation score (CCS)

numerical rating scale (NRS) of pain and Chinese version of European Organisation for Research and Treatment of Cancer

Quality of Life Questionnaire-C30 V3.0 (EORTC QLQ-C30 V3.0) were used to evaluate the efficacy

关键词

Chinese MedicineopioidConstipationquality of life

Keywords

Chinese MedicineopioidConstipationquality of life

references

Cohen MZ, Easley MK, Ellis C, Hughes B, Ownby K, Rashad BG, et al. Cancer pain management and the JCAHO’s pain standards:an institutional challenge. J Pain Symptomf Manage 2003;25:519–527.

Goudas LC, Bloch R, Gialeli-Goudas M, Lau J, Carr DB. The epidemiology of cancer pain. Cancer Investigat 2005;23:182–190.

Svendsen KB, Andersen S, Arnason S, Arnér S, Breivik H, Heiskanen T, et al. Breakthrough pain in malignant and nonmalignant diseases: a review of prevalence, characteristics and mechanisms. Eur J Pain 2005;9:195–206.

World Health Organization. Cancer pain relief. 2nd ed. Geneva, Switzerland: World Health Organization;1996.

Sun Y, Shi YK. Manual of clinical oncology. Beijing: People’s Medical Publishing House; 2007:277.

Cherny N, Ripamonti C, Pereira J, Davis C, Fallon M, McQuay H, et al. Strategies to manage the adverse effects of oral morphine: an evidence-based report. J Clin Oncol 2001;19:2542–2554.

Yu CP, An JX. How to prevent and control opioid-induced constipation. China Prescript Drug (Chin) 2008;8:74–76.

Liu M, Wittbrodt E. Low-dose oral naloxone reverses opioid-induced constipation and analgesia. J Pain Symptom Manage 2002;23:48–53.

Wang LN, Li J, Li DR, Lin HS. The status quo of the treatment of opioid-induced constipation with Chinese medicine. Chin J Integr Tradit West Med (Chin) 2010;16:116–119.

American College of Gastroenterology Chronic Constipation Task Force. An evidence-based approach to the management of chronic constipation in North America. Am J Gastroenterol 2005;100(Suppl 1):S1–S4.

Ministry of Health of the People’s Republic of China. Guideline for Clinical Study of New Chinese Medicines. Beijing, China: Ministry of Health of the People’s Republic of China; 1993:131–133.

EORTC Quality of Life Group. Guidelines for assessing quality of life in EORTC clinical trials. Brussels, Belgium: Quality Life Unit, EORTC Data Center 2002;22(15):21–24.

Wa CH, Chen MQ, Zhang CZ, Tang XL, Meng Q, Zhang XQ. The Chinese version of EORTC QLQ-C3 form in evaluation of QOL for patients with cancer. J Pract Oncol (Chin) 2005;10:353–355.

Swarm R, Abernethy AP, Anghelescu DL, Benedetti C, Blinderman CD, Boston B, et al. NCCN clinical practice guidelines in oncology on adult cancer pain. J Natl Compr Canc Netw 2010;8:1055.

Common Terminology Criteria for Adverse Events v3.0. Available at: http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf. Accessed July 30, 2011.

Wood JD, Galligan JJ. Function of opioids in the enteric nervous system. Neurogastroenterol Motil 2004;16:17–28.

Galligan JJ, Vanner S. Basic and clinical pharmacology of new motility promoting agents. Neurogastroenterol Motil 2005;17:643–653.

De Schepper HU, Cremonini F, Park MI, Camilleri M. Opioids and the gut: pharmacology and current clinical experience. Neurogastroenterol Motil 2004;16:383–394.

Choi YS, Billings JA. Opioid antagonists: a review of their role in palliative care, focusing on use in opioid-related constipation. J Pain Symptom Manage 2002;24:71–90.

Gu Y J, Chen J, Sun YY, Zhang X. Clinical observation on Jiangni Kuanchang Decoction for opioid-related constipation. Liaoning J Tradit Chin Med (Chin) 2009;36:233–234.

Tian DL. Internal medicine of traditional Chinese medicine. Beijing: People’s Medical Publishing House; 2006:226–230.

Zhao YL, Zhang ZH, Wang ZR. Relationship between purgative effect of Rhubarb and 5-HT and it’s receptor in duodenum tissues. J Yunnan Univ Tradit Chin Med (Chin) 2002;25:1–3.

Yu M, Luo YL, Zheng JW, Ding YH, Li W, Zheng TZ, et al. Effects of Rhubarb on isolated gastric muscle strips of guinea pigs. World J Gastroenterol 2005;11:2670–2673.

Zhang QR, Li L, Chen DS, Peng JX, Wang XW. Effects of Cortex magnoliae officinalis, Fructus aurantii immaturus, Rhubarb and Pericarpium citri reticulatae on rabbits’ isolated fundal smooth muscle movement. Chin J Tradit Med Sci Technol (Chin) 2008;15:279–280.

Wang, CF, Yang DZ, Wei YQ, Xun QY. Study on the effect of Fructus aurantii immaturus on myoelectric of gastrointestinal tract in rats. J Southeast Univ (Med Sci Ed, Chin) 2001;20:153–154.

Zhang QR, Ding L, Zhao XM, Guo XD, Li L. The effect of Cortex magnoliae officinalis on the movement of rabbits’ dissociated smooth muscles of intestine and stomach. Shaanxi Med J (Chin) 2007;36:656–659.

FULL TEXT LINK

More>

Views

1036

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

Effectiveness of Bufei Yishen Granule (补肺益肾颗粒) combined with acupoint sticking therapy on quality of life in patients with stable chronic obstructive pulmonary disease

Chinese medicine improves postoperative quality of life in endometriosis patients: A randomized controlled trial

Effect of Feitai Capsule (肺泰胶囊) on quality of life and progression-free survival of patients with unresectable non-small cell lung cancer

Effect of traditional and integrative regimens on quality of life and early renal impairment in elderly patients with isolated systolic hypertension

Effect of Yangxinkang Tablets (养心康片) on chronic heart failure: A multi-center randomized double-blind placebo-controlled trial

Related Author

No data

Related Institution

Dongzhimen Hospital, Beijing University of Chinese Medicine

The Geriatric Department, Henan University of Traditional Chinese Medicine

Department of Respiratory, the First Affiliated Hospital of Henan University of Traditional Chinese Medicine

Department of Respiratory, the First Affiliated Hospital of Anhui College of Traditional Chinese Medicine

Department of Acupuncture and Moxibustion, the Third Affiliated Hospital of Henan University of Traditional Chinese Medicine

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰