Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients

Qiang Liu; Xiao-jia Su; Yan Yu; Yong-lin Liu

doi:10.1007/s11655-014-1880-9

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Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients

Updated：2021-08-27

- Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients
- Chinese Journal of Integrative Medicine Vol. 20, Issue 12, Pages: 928-933(2014)
- Affiliations：
  
  1. Department of Cardiology, the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China
  2. Department of Cardiology, Hospital of Liberation Army,Henan Province,Xinxiang,China,371
  3. Department of Laboratory, the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou,China
- Author bio：
- Funds：
  
  Supported by the Chinese Medicine Project of Zhejiang Province, China (No.2007CB144)
- DOI：10.1007/s11655-014-1880-9
  CLC：
- Published：2014，
  
  Published Online：14 July 2014，
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Liu, Q., Su, Xj., Yu, Y. et al. Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients., Chin. J. Integr. Med. 20, 928–933 (2014). https://doi.org/10.1007/s11655-014-1880-9

Qiang Liu, Xiao-jia Su, Yan Yu, et al. Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients. [J]. Chinese Journal of Integrative Medicine 20(12):928-933(2014)
Liu, Q., Su, Xj., Yu, Y. et al. Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients., Chin. J. Integr. Med. 20, 928–933 (2014). https://doi.org/10.1007/s11655-014-1880-9 DOI：

Qiang Liu, Xiao-jia Su, Yan Yu, et al. Correlations among persistent viral infection, heart function and Chinese medicine syndromes in dilated cardiomyopathy patients. [J]. Chinese Journal of Integrative Medicine 20(12):928-933(2014) DOI： 10.1007/s11655-014-1880-9.

摘要

To investigate the correlations among persistent viral infection

heart function and Chinese medicine (CM) difined-syndromes in patients with dilated cardiomyopathy (DCM). Fifty patients with DCM in the First Affiliated Hospital of Zhejiang Chinese Medical University from October 2009 to December 2011 were selected as the research subjects

and 30 healthy people were simultaneously selected as the normal control group to detect persistent viral infections after admission. The CM syndrome type and grade of heart function were then evaluated. The expression level of Coxsackie adenovirus receptor (CAR) was detected using the flow cytometry (FCM) technique

coxsackie virus RNA (CVB-RNA) using reverse transcription polymerase chain reaction (RTPCR)

and the plasma brain natriuretic peptide (BNP) level with a Triage meter plus diagnosis instrument. Finally

the parameters such as left ventricular end diastolic diameter (LVEDd) and left ventricular ejection fraction (LVEF) were measured by ultrasonic cardiogram. Person correlation analysis was used for measured data

Spearman correlation analysis for rating data

and the Chi-square test for numerical data. CVB-RNA was positive in 22 patients (44%) with DCM

while only 6 cases (20%) were CVB-RNA-positive in the normal control group

with a significant difference between the two groups (P<0.01). The expression level of CAR was significantly elevated in the DCM group compared with the normal control group (P<0.01). In CVB-RNA-positive patients (22 cases)

the expression level of CAR was significantly higher than in CVB-RNA-negative patients (28 cases; P<0.01). In the DCM patients

there was a positive correlation between the CAR expression and the BNP level (r=0.34

P<0.05)

while no significant difference was found between the CAR expression and the LVEF and LVEDd (r=−0.32

0.30

P>0.05). There was no clear correlation between virus infection and the CM syndrome types in DCM patients (r=−0.22

P>0.05). According to the sequence of syndrome types: phlegm → qi deficiency → blood stasis → hydroretention with asthenic yang (from low to high)

a positive correlation was existed between the BNP levels and CM syndrome types (r=0.139

P<0.05). The expression of CAR on the surface of white cells could be used to detect persistent viral infection. The expression level of CAR and heart function in DCM patients were highly correlated. The expression level of BNP may serve as an objective index for differentiating CM syndromes for patients with DCM.

Abstract

To investigate the correlations among persistent viral infection

coxsackie virus RNA (CVB-RNA) using reverse transcription polymerase chain reaction (RTPCR)

and the plasma brain natriuretic peptide (BNP) level with a Triage meter plus diagnosis instrument. Finally

Spearman correlation analysis for rating data

and the Chi-square test for numerical data. CVB-RNA was positive in 22 patients (44%) with DCM

while only 6 cases (20%) were CVB-RNA-positive in the normal control group

the expression level of CAR was significantly higher than in CVB-RNA-negative patients (28 cases; P<0.01). In the DCM patients

there was a positive correlation between the CAR expression and the BNP level (r=0.34

P<0.05)

while no significant difference was found between the CAR expression and the LVEF and LVEDd (r=−0.32

0.30

P>0.05). There was no clear correlation between virus infection and the CM syndrome types in DCM patients (r=−0.22

P>0.05). According to the sequence of syndrome types: phlegm → qi deficiency → blood stasis → hydroretention with asthenic yang (from low to high)

a positive correlation was existed between the BNP levels and CM syndrome types (r=0.139

关键词

dilated cardiomyopathypersistent viral infectioncoxsackie adenovirus receptorheart functionChinese medicine syndrome typebrain natriuretic peptide

Keywords

dilated cardiomyopathypersistent viral infectioncoxsackie adenovirus receptorheart functionChinese medicine syndrome typebrain natriuretic peptide

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Department of Cardiovascular Diseases, Wuxi Municipal Hospital of Traditional Chinese Medicine, Wuxi City

Department of Cardiology, Xinhua Hospital Affiliated to the Medical College of Shanghai Jiao Tong University

Department of Laboratory, Ruijin Hospital Affiliated to the Medical College of Shanghai Jiao Tong University

Department of Internal Cardiology, Xinhua Hospital Affiliated to Shanghai Jiaotong University

Department of Laboratory, Ruijin Hospital, Shanghai Jiaotong University School of Medicine

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