Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment

Xiao-long Wang

doi:10.1007/s11655-014-1892-5

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Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment

Updated：2021-08-27

- Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment
- Chinese Journal of Integrative Medicine Vol. 21, Issue 1, Pages: 3-9(2015)
- Affiliations：
  
  Cardiovascular Department, Shanghai Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1892-5
  CLC：
- Published：2015，
  
  Published Online：24 December 2014，
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Wang, Xl. Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment., Chin. J. Integr. Med. 21, 3–9 (2015). https://doi.org/10.1007/s11655-014-1892-5

Xiao-long Wang. Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment. [J]. Chinese Journal of Integrative Medicine 21(1):3-9(2015)
Wang, Xl. Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment., Chin. J. Integr. Med. 21, 3–9 (2015). https://doi.org/10.1007/s11655-014-1892-5 DOI：

Xiao-long Wang. Potential herb-drug interaction in the prevention of cardiovascular diseases during integrated traditional and western medicine treatment. [J]. Chinese Journal of Integrative Medicine 21(1):3-9(2015) DOI： 10.1007/s11655-014-1892-5.

摘要

The combination of herbs and drugs is one of the most important approaches in the prevention and treatment of diseases in the integrated traditional and Western medicine (ITWM). While most medical practices have proved that the combination of herbs and drugs led to a clinical efficacy that was often superior to merely using only one of them; results from some studies have triggered adverse reactions to such an approach. Since few herb-drug interaction studies were carried out during treatments combining herbs and drugs

it really restricts the development of treatment and treatment theory of the combination of herbs and drugs. Given that herb-drug interactions may occur through the main pathway of cytochrome P450 enzymes and transporters; then to exhaustively study the role and impact of herbs in drug metabolism

as well as to establish a corresponding database

is of great significance for guiding the rational combination of herbs and drugs. When the herb-drug interaction information platform is implemented

we would get at ease a reasonable herb-drug prescription to achieve a better outcome

reduce dosage of some expensive drugs preserving the same efficacy

or even reduce some side effects of particular drugs; which might also promote the dynamic combination of Chinese and Western medicine

and accelerate the theory development of ITWM.

Abstract

as well as to establish a corresponding database

is of great significance for guiding the rational combination of herbs and drugs. When the herb-drug interaction information platform is implemented

we would get at ease a reasonable herb-drug prescription to achieve a better outcome

reduce dosage of some expensive drugs preserving the same efficacy

or even reduce some side effects of particular drugs; which might also promote the dynamic combination of Chinese and Western medicine

and accelerate the theory development of ITWM.

关键词

integrated traditional and Western medicineherb-drug interactioncytochrome P450transportercardiovascular disease

Keywords

integrated traditional and Western medicineherb-drug interactioncytochrome P450transportercardiovascular disease

references

Lu CX. The basic principles of the combination of Chinese herbs and Western drugs. Lishizhen Med Mater Med Res (Chin) 2005;16:937.

Mao ZD. Vigorously accelerate the development of Chinese medicine. People’s Daily 1978-11-02(1).

Yin CJ. Integrative traditional and Western medicine: the only way for the development of Chinese medicine. Tianjin J Tradit Chin Med (Chin) 2010;27:171–179.

Long X, Li H, Zhan YF, Feng M. Exploration on interaction of Chinese and Western drugs. Chin J Integr Tradit West Med (Chin) 2009;29:457–460.

Yang XL. Case analysis on the combination of Chinese and Western medicine. Nei Mongol J Tradit Chin Med (Chin) 2014;6:85.

Pei X. Rational use of traditional Chinese medicine injection and prevention of adverse reactions. Chin J Clin (Chin) 2014;42:79–80.

Ouyang Y, Yan CX, Liao YF. Analysis and countermeasures on 127 cases of Chinese and Western medicine unreasonable combination. Med Innov China (Chin) 2014;11:123–125.

Zhao H. Considerations of the combination of Chinese and Western medicine. Chin Commun Doct (Chin) 2008;10:9–10.

Li P. The incompatibility analysis of the combination of Chinese and Western medicine. China Pract Med (Chin) 2012;7:92–93.

Li YP, Zhang MH. Current situation and prospect of the combination of Chinese and Western medicine. J Tradit Chin Med Managem (Chin) 2013;21:569–572.

Yan XF, Ni Q, Wang LF, Liu BY. Status and trends of traditional medicine used as Western and the combination of traditional Chinese medicine and Western medicine. J Tradit Chin Med (Chin) 2012;53:1870–1872.

Yuan HW, Yuan JQ. Advantages and problems solving strategies of integrated application of Western and traditional Chinese medicine. World Chin Med (Chin) 2013;8:820–822.

Ohnishi N, Yokoyama T. Interactions between medicines and functional foods or dietary supplements. Keio J Med 2004;53:137–150.

Sugiyama T, Kubota Y, Shinozuka K, Yamada S, Yamada K, Umegaki K, et al. Induction and recovery of hepatic drug metabolizing enzymes in rats treated with Ginkgo biloba extract. Food Chemic Toxicol 2004;42:953–957.

Fan L, Zhang W, Guo D, Tan ZR, Xu P, Li Q, et al. The effect of herbal medicine baicalin on pharmacokinetics of rosuvastatin, substrate of organic anion transporting polypeptide 1B1. Clin Pharmacol Ther 2008;83:471–476.

Guengerich FP. Cytochrome P450 and chemical toxicology. Chem Res Toxicol 2008;21:70–83.

Berka K, Hendrychová T, Anzenbacher P, Otyepka M. Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site. J Phys Chem A 2011;115:11248–11255.

Weng XG, Zhu XX, Liang RX, Yang Q, Li YJ, Wang YW, et al. Review on interaction between herb metabolism and cytochrome P450. Chin J Exp Tradit Med Formul (Chin) 2009;15:104–108.

Wang XL, Wang YJ, Mao YC, Shen ZJ, Hu ZH. Inhibitory action of Jiangzhi Decoction on isozyme 3A4 of cytchrome P450. Shanghai J Tradit Chin Med (Chin) 2012;46:76–79.

Guo F, Li YN, Mao YC, Shen ZJ, Xu DD, Chou GX, et al. Metabolism based herb-drug interaction-lipid-lowering herbs and atorvastatin in vitro. Progr Modern Biomed (Chin) 2014;14:1611–1615.

Wang YJ, Shen JZ, Wang XL, Mao YC, Guo W, Hu ZH. Effect of Tonifying Spleen and Eliminating Turbidity Decoction on atorvastatin metabolism in vitro. Intern J Cardiovasc Dis (Chin) 2013;40:376–378.

Xu B, Zhao G, Wei H, Qian XF, Li JX, Xu W. Effects of 20 Chinese patent medicines on the catalytic activities of five main cytochrome P450s of human liver microsome. J Pharm Pract (Chin) 2009;27:353–356.

Bu MH, Zheng YQ, Zhang Y, Li LQ, Liu JX, Liu DC. Impact of cardiovascular drug Quick-Acting Heart Reliever and Tongxinluo Capsules on CYP450s in rats after successive administration. Chin J Clin Pharm Therap (Chin) 2011;16:601–605.

Wei BH, Wang MJ, Kuang CY. Impact of Compound Danshen Dripping Pills on CYP450s in rats liver microsome. J Chin Med Mater (Chin) 2006;29:1340–1342.

Wang LS, Zhou G, Zhu B, Wu J, Wang JG, Abd El-Aty AM, et al. St John’s wort induces both cytochrome P450 3A4-catalyzed sulfoxidation and 2C19-dependent hydroxylation of omeprazole. Clin Pharmacol Ther 2004;75:191–197.

Yang LJ, Fan L, Liu ZQ, Mao YM, Guo D, Liu LH, et al. Effects of allicin on CYP2C19 and CYP3A4 activity in healthy volunteer with different CYP2C19 genotypes. Eur J Clin Pharmacol 2009;65:601–608.

Bu MH, Zheng YQ, Zhang Y, Li LQ, Liu JX, Liu DC. Impact of Shenmai Injection and Xuesaitong Injection on CYP450s in rat liver and intestine after successive administration. Chin J Clin Pharmacol (Chin) 2012;28:49–52.

Liu Y, Ma H, Zhang JW, Deng MC, Yang L. Influence of ginsenoside Rh1 and F1 on human cytochrome P450 enzymes. Planta Med 2006;72:126–131.

Shi J, Chen AJ, Zhang F, Wang BJ. Effects of traditional Chinese medicine Panax notoginoside and tetramethylpyrazine on cytochrome P450 subtype enzymes. Chin J Integr Tradit West Med Intens Crit Care (Chin) 2008;15:342–345.

Liu SJ, Ju WZ, Chen WK, Xu LJ, Xiong NN, Tan HS. Influence of Xueshuantong Injection on P450 activities using a cocktail method. Chin Pharm J (Chin) 2010;45:115–118.

Li XY, Liu GL, Zhou JC, Qian G, Gao JW, Sun B, et al. Experimental study on the effects of liver cytochrome protein 450 (CYP450) induced by Panax Notoginsenoside Injection in rats. Chin J Clin Pharmacol Ther (Chin) 2009;14:849–854.

Wang QB, Di W, Chen XL, Zhang PH, Tu ZL. Effects of puerarin on the activities of cytochrome P450 enzyme in vitro. Herald Med (Chin) 2008;27:500–504.

Chen WK, Ju WZ, Xu LJ. Effects of Mailuoning Injection on hepaticmetabolic enzymes of mice. Pharm Clin Res (Chin) 2008;16:351–354.

Liu R, Liu GF, Zhao YG. Regulation of traditional Chinese medicine injections on cytochrome P450 enzyme isoforms. Herald Med (Chin) 2011;30:883–887.

Han YL, Yu Q, Meng XL, Li D, Bian K, Guo C. Inhibition of Dengzhan Xixin Injection on rat liver microsomal CYP3A. Chin J Clin Pharmacol Ther (Chin) 2009;14:891–895.

Liu GF, Guo XL, Huang LJ. Inhibition of Honghua Injection on CYP2D6 in rats. Chin Tradit Herbal Drugs (Chin) 2008;39:1829–1833.

Tan R. Research on the interaction of P-glycoprotein with Chinese medicine and its chemical composition. Chin Hosp Pharm J (Chin) 2009;29:2028–2029.

Dong HM. Discussion on digoxin adverse interactions compatibility with traditional Chinese medicine. Chin J Mod Drug Appl (Chin) 2009;3:160–161.

Li Z, Zhuang XM, Li SY, Zhang ZQ, Ruan JX. Research progress in herb inhibitions on P-glycoprotein. Pharm J Chin PLA (Chin) 2009;25:326–329.

Cen J, Zhang F, Ji BS. Research progress in natural products with regulation target on P-glycoprotein. Chin Tradit Herbal Drugs (Chin) 2013;44:905–909.

Liu LJ, Hu DL, Li HJ, Fan L, Zhou HH. Effect of aescin on P-glycoprotein activity. Progr Modern Biomed (Chin) 2010;10:1208–1211.

Liang WJ, Shan BE. Research progress in antagonistic mechanism of Chinese materia medica on multidrug resistance of tumorous cells mediated by P-glycoprotein. Chin Traditi Herbal Drugs (Chin) 2013;44:905–909.

Jing J, Zheng H, Wang J, Lin P, Zhang J, Xiong ZJ. Growth inhibition and multidrug resistance-reversing effect of tanshinone IIA on human breast cancer cell with estrogen receptor negative. J Sichuan Univ (Med Sci Ed Chin) 2007;38:391–395.

Bush TM, Rayburn KS, Holloway SW, Sanchez-Yamamoto DS, Allen BL, Lam T, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30–35.

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