Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis

Jia-rui Wu; Xiao-meng Zhang; Bing Zhang

doi:10.1007/s11655-014-1895-2

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Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis

Updated：2021-08-27

- Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis
- Chinese Journal of Integrative Medicine Vol. 21, Issue 11, Pages: 866-873(2015)
- Affiliations：
  
  Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
- DOI：10.1007/s11655-014-1895-2
  CLC：
- Published：2015，
  
  Published Online：9 December 2014，
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Wu, Jr., Zhang, Xm. & Zhang, B. Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis., Chin. J. Integr. Med. 21, 866–873 (2015). https://doi.org/10.1007/s11655-014-1895-2

Jia-rui Wu, Xiao-meng Zhang, Bing Zhang. Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 21(11):866-873(2015)
Wu, Jr., Zhang, Xm. & Zhang, B. Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis., Chin. J. Integr. Med. 21, 866–873 (2015). https://doi.org/10.1007/s11655-014-1895-2 DOI：

Jia-rui Wu, Xiao-meng Zhang, Bing Zhang. Potassium Dehydroandrographolide Succinate Injection for the treatment of child epidemic parotitis: A systematic review and meta-analysis. [J]. Chinese Journal of Integrative Medicine 21(11):866-873(2015) DOI： 10.1007/s11655-014-1895-2.

摘要

To systematically evaluate the clinical efficacy and safety of Potassium Dehydroandrographolide Succinate Injection (PDSI) in the treatment of child epidemic parotitis (EP). Randomized controlled trials (RCTs) regarding PDSI in the treatment of child EP were searched in China National Knowledge Infrastructure

Wanfang Database

Chinese Biomedical Literature Database

PubMed

and Cochrane Library from inception to July 30

2013. Two reviewers independently retrieved RCTs and extracted information. The Cochrane risk of bias method was used to assess the quality of included studies

and a metaanalysis was conducted with RevMan 5.2 software. A total of 11 studies with 818 participants were included. The quality of the studies was generally low

among which only one study mentioned the random method. The meta-analysis indicated that PDSI was more effective than the conventional therapy with Western medicine for EP in the outcomes of the total effective rate [relative risk (RR)=1.23

95% confifidence interval (CI) [1.14

1.33]

P<0.01]

the time of temperature return to normal

the time of detumescence [mean difference (MD)=–2.10

95% CI [–2.78

–1.41]

P<0.01]

and the incidence of complications (RR=0.14

95% CI [0.03

0.72]

P=0.02). There were 6 adverse drug reactions (ADRs) in this systematic review

2 of which were mainly represented rash and diarrhea in the experiment group

while another 4 ADRs occurred in the control group. Based on the systematic review

PDSI was effectiveness and relatively safety in the treatment of child EP. But further rigorously designed trials are warranted to determine its effectiveness.

Abstract

Wanfang Database

Chinese Biomedical Literature Database

PubMed

and Cochrane Library from inception to July 30

2013. Two reviewers independently retrieved RCTs and extracted information. The Cochrane risk of bias method was used to assess the quality of included studies

and a metaanalysis was conducted with RevMan 5.2 software. A total of 11 studies with 818 participants were included. The quality of the studies was generally low

95% confifidence interval (CI) [1.14

1.33]

P<0.01]

the time of temperature return to normal

the time of detumescence [mean difference (MD)=–2.10

95% CI [–2.78

–1.41]

P<0.01]

and the incidence of complications (RR=0.14

95% CI [0.03

0.72]

P=0.02). There were 6 adverse drug reactions (ADRs) in this systematic review

2 of which were mainly represented rash and diarrhea in the experiment group

while another 4 ADRs occurred in the control group. Based on the systematic review

PDSI was effectiveness and relatively safety in the treatment of child EP. But further rigorously designed trials are warranted to determine its effectiveness.

关键词

Potassium Dehydroandrographolide Succinate Injectionchild epidemic parotitismeta-analysissystematic reviewChinese Medicine

Keywords

Potassium Dehydroandrographolide Succinate Injectionchild epidemic parotitismeta-analysissystematic reviewChinese Medicine

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Guang’anmen Hospital, China Academy of Chinese Medical Sciences

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences

China Academy of Chinese Medical Sciences

Department of Nephrology, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases

Division of Infectious Diseases, Chinese PLA Hospital

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