Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis

Si-jun Liu; Zhao-sheng Huang; Qing-guang Wu; Zhang-jie Huang; Li-rong Wu; Wen-li Yan; Qi Wang; Zong-wei Wang; David Lungpao Chang; Zheng Yang

doi:10.1007/s11655-014-1897-0

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Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis

Updated：2021-08-27

- Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis
- Chinese Journal of Integrative Medicine Vol. 22, Issue 4, Pages: 258-266(2016)
- Affiliations：
  
  1. Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine,Guangzhou,China
  2. School of Chinese Materia Medica, Guangzhou University of Chinese Medicine,Guangzhou,China
  3. Massachusetts General Hospital, Harvard Medical School,Boston,USA
  4. Colgate-Palmolive (China) Co., Ltd.,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81273817) and the Program of Guangdong Province Administration of Traditional Chinese Medicine (No. 20121225)
- DOI：10.1007/s11655-014-1897-0
  CLC：
- Published：2016，
  
  Published Online：18 December 2014，
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Liu, Sj., Huang, Zs., Wu, Qg. et al. Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis., Chin. J. Integr. Med. 22, 258–266 (2016). https://doi.org/10.1007/s11655-014-1897-0

Si-jun Liu, Zhao-sheng Huang, Qing-guang Wu, et al. Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis. [J]. Chinese Journal of Integrative Medicine 22(4):258-266(2016)
Liu, Sj., Huang, Zs., Wu, Qg. et al. Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis., Chin. J. Integr. Med. 22, 258–266 (2016). https://doi.org/10.1007/s11655-014-1897-0 DOI：

Si-jun Liu, Zhao-sheng Huang, Qing-guang Wu, et al. Study on diagnosis criteria of fire-heat syndrome based on receiver operating characteristic curve and principal component analysis. [J]. Chinese Journal of Integrative Medicine 22(4):258-266(2016) DOI： 10.1007/s11655-014-1897-0.

摘要

To establish the diagnostic quantitative criteria for fire-heat syndrome (FHS) of Chinese medicine (CM) based on the receiver operating characteristic (ROC) curve and principal component analysis (PCA). The symptoms and signs of FHS cases and healthy subjects from Guangzhou

Henan and Hunan of China were collected through questionnaire

and the diagnostic quantitative score tables were established for the three regions

respectively

with the method of maximum likelihood analysis. The homogeneity test was then performed on the diagnostic score tables for the three regions with ROC curve

and the diagnostic efficiency of diagnostic score tables for the three regions was compared with the prospective test and retrospective test. The method of PCA was adopted to obtain the analysis matrix for classifying the tapes of FHS. Twenty-seven elements of FHS were confirmed through Chi-square test

and the diagnostic score tables for the three regions were established with the method of maximum likelihood analysis on the basis of the collected case data. According to the ROC curve test

the areas under ROC curve of Guangzhou diagnostic score table assessment with candidates in Guangzhou

Henan and Hunan were 0.998

0.961 and 0.956

respectively. It showed that the diagnostic efficiency of Guangzhou diagnostic score tables was the highest one. With the prospective test

the area under ROC of Guangzhou diagnostic score table was 0.949

and more than any other diagnostic score table. By PCA

FHS was classified into excess fire and deficiency fire

and then classified into syndrome of flaring up of Heart (Xin) fire

syndrome of Lung (Fei)-Stomach (Wei) excess fire

syndrome of deficiency of Liver (Gan)-yin and Kidney (Shen)-yin

and syndrome of deficiency of Lung-yin from the view of viscera. In the retrospective test

the consistency with clinicians' diagnosis was 69.4%

and in the prospective test

it was 70.1%. The Guangzhou diagnostic score table could be used as the recommended criteria for the diagnosis of FHS. The classification of FHS was basically in conformity with the clinical situation.

Abstract

Henan and Hunan of China were collected through questionnaire

and the diagnostic quantitative score tables were established for the three regions

respectively

with the method of maximum likelihood analysis. The homogeneity test was then performed on the diagnostic score tables for the three regions with ROC curve

and the diagnostic score tables for the three regions were established with the method of maximum likelihood analysis on the basis of the collected case data. According to the ROC curve test

the areas under ROC curve of Guangzhou diagnostic score table assessment with candidates in Guangzhou

Henan and Hunan were 0.998

0.961 and 0.956

respectively. It showed that the diagnostic efficiency of Guangzhou diagnostic score tables was the highest one. With the prospective test

the area under ROC of Guangzhou diagnostic score table was 0.949

and more than any other diagnostic score table. By PCA

FHS was classified into excess fire and deficiency fire

and then classified into syndrome of flaring up of Heart (Xin) fire

syndrome of Lung (Fei)-Stomach (Wei) excess fire

syndrome of deficiency of Liver (Gan)-yin and Kidney (Shen)-yin

and syndrome of deficiency of Lung-yin from the view of viscera. In the retrospective test

the consistency with clinicians' diagnosis was 69.4%

and in the prospective test

关键词

receiver operating characteristic curveprincipal component analysisdiagnostic criteriafire-heat syndromeChinese Medicine

Keywords

receiver operating characteristic curveprincipal component analysisdiagnostic criteriafire-heat syndromeChinese Medicine

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