Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial

Da-zhi Sun; Jian-peng Jiao; Xuan Zhang; Jing-yu Xu; Min Ye; Li-juan Xiu; Ying Zhao; Ye Lu; Xuan Liu; Jing Zhao; Jun Shi; Zhi-feng Qin; Pin-kang Wei

doi:10.1007/s11655-014-1950-z

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Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial

Updated：2021-08-27

- Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial
- Chinese Journal of Integrative Medicine Vol. 21, Issue 8, Pages: 579-586(2015)
- Affiliations：
  
  Department of Traditional Chinese Medicine, Changzheng Hospital, Second Military Medical University,Shanghai,China
- Author bio：
- Funds：
  
  Supported by Shanghai Changzheng Hospital Youth Foundation Project (No. 200917)
- DOI：10.1007/s11655-014-1950-z
  CLC：
- Published：2015，
  
  Published Online：16 November 2014，
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Sun, Dz., Jiao, Jp., Zhang, X. et al. Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 579–586 (2015). https://doi.org/10.1007/s11655-014-1950-z

Da-zhi Sun, Jian-peng Jiao, Xuan Zhang, et al. Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 21(8):579-586(2015)
Sun, Dz., Jiao, Jp., Zhang, X. et al. Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial., Chin. J. Integr. Med. 21, 579–586 (2015). https://doi.org/10.1007/s11655-014-1950-z DOI：

Da-zhi Sun, Jian-peng Jiao, Xuan Zhang, et al. Therapeutic effect of Jinlongshe Granule (金龙蛇颗粒) on quality of life of stage IV gastric cancer patients using EORTC QLQ-C30: A double-blind placebo-controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 21(8):579-586(2015) DOI： 10.1007/s11655-014-1950-z.

摘要

To evaluate the impact of Jinlongshe Granule (金龙蛇颗粒

JLSG) on quality of life (QOL) of stage IV gastric cancer patients. This randomized

double-blind and placebo-controlled clinical trial included 50 patients with advanced gastric cancer. They were equally randomized into a JLSG group and a placebo group. Patients in both groups received routine Chinese herbal decoctions according to Chinese medicine (CM) treatment based on syndrome differentiation. Patients in JLSG group received additional JLSG

and those in the placebo group received an additional placebo. In the JLSG group

19 patients who completed the study were used for analysis. In the placebo group

finally the data of 20 patients who completed the study were used for analysis. The treatment course was at least 3 months

and the follow-up duration was at least 6 months in 5 interviews. Repeated measurements of the subscale items and individual items in European Organization for Research and Treatment of Cancer Core Quality of Life Questionnaire C30 (EORTC QLQ-C30) obtained at the 5 interviews were compared using different patient groups

changes over time and changes within one group over time independently to observe the tendency of changes in the scores. Using time as the variant

there was signifificant difference in 4 functional scales (physical

role

emotional and social

P<0.05)

3 symptom scales (fatigue

nausea and vomiting and pain

P<0.05) and a global health status/QOL scale (P<0.05) and 6 single symptoms dyspnoea (P>0.05)

insomnia (P<0.05)

appetite loss (P<0.05)

constipation (P<0.05)

diarrhea (P>0.05) and financial difficulties (P<0.05). There was also signifificant difference in these items between the two groups when the placebo group and group over time were used as variants (P<0.05 or P<0.01). Additional use of JLSG on the basis of routine CM treatment could improve the somatic function

role function

emotional function

social function

cognitive function and general QOL of patients with advanced gastric cancer

and relieve the symptoms of fatigue

nausea and vomiting

pain

loss of appetite and constipation.

Abstract

To evaluate the impact of Jinlongshe Granule (金龙蛇颗粒

JLSG) on quality of life (QOL) of stage IV gastric cancer patients. This randomized

and those in the placebo group received an additional placebo. In the JLSG group

19 patients who completed the study were used for analysis. In the placebo group

finally the data of 20 patients who completed the study were used for analysis. The treatment course was at least 3 months

changes over time and changes within one group over time independently to observe the tendency of changes in the scores. Using time as the variant

there was signifificant difference in 4 functional scales (physical

role

emotional and social

P<0.05)

3 symptom scales (fatigue

nausea and vomiting and pain

P<0.05) and a global health status/QOL scale (P<0.05) and 6 single symptoms dyspnoea (P>0.05)

insomnia (P<0.05)

appetite loss (P<0.05)

constipation (P<0.05)

role function

emotional function

social function

cognitive function and general QOL of patients with advanced gastric cancer

and relieve the symptoms of fatigue

nausea and vomiting

pain

loss of appetite and constipation.

关键词

Gastric CancerJinlongshe Granulequality of liferandomized placebo controlled study

Keywords

Gastric CancerJinlongshe Granulequality of liferandomized placebo controlled study

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