A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism

Hui Chen; Xiao-ying Wu; Hong-xia Wu; Huan Wang

doi:10.1007/s11655-014-2023-z

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A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism

Updated：2021-08-27

- A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism
- Chinese Journal of Integrative Medicine Vol. 20, Issue 12, Pages: 894-902(2014)
- Affiliations：
  
  Fujian Provincial Cardiovascular Disease Institute, Provincial Clinical College of Fujian Medical University,Fuzhou,China
- Author bio：
- Funds：
  
  Supported by the Provincial Natural Science Foundation of Fujian (No. 2011J0133) and the National Natural Science Foundation of China (No. 81373838)
- DOI：10.1007/s11655-014-2023-z
  CLC：
- Published：2014，
  
  Published Online：27 November 2014，
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Chen, H., Wu, Xy., Wu, Hx. et al. A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism., Chin. J. Integr. Med. 20, 894–902 (2014). https://doi.org/10.1007/s11655-014-2023-z

Hui Chen, Xiao-ying Wu, Hong-xia Wu, et al. A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism. [J]. Chinese Journal of Integrative Medicine 20(12):894-902(2014)
Chen, H., Wu, Xy., Wu, Hx. et al. A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism., Chin. J. Integr. Med. 20, 894–902 (2014). https://doi.org/10.1007/s11655-014-2023-z DOI：

Hui Chen, Xiao-ying Wu, Hong-xia Wu, et al. A randomized controlled trial of adjunctive Bunchang Naoxintong Capsule (步长脑心通胶囊) versus maintenance dose clopidogrel in patients with CYP2C19*2 polymorphism. [J]. Chinese Journal of Integrative Medicine 20(12):894-902(2014) DOI： 10.1007/s11655-014-2023-z.

摘要

To determine the impact of adjunctive Buchang Naoxintong Capsule (步长脑心通胶囊

NXT) on dual antiplatelet therapy in patients with cytochrome P450 2C19*2 (CYP2C19*2) polymorphism undergoing percutaneous coronary intervention (PCI). Ninety patients with CYP2C19*2 polymorphism were enrolled

and their genotypes were confirmed by polymerase chain reaction (PCR). The patients were randomly assigned to receive either adjunctive NXT (triple group

45 cases) or dual antiplatelet therapy (dual group

45 cases) using a computer-generated randomization sequence and sealed envelopes. Platelet function was assessed at baseline and 7 days after treatment with conventional aggregometry. Subsequent major adverse cardiovascular events (MACE

including sudden cardiac arrest and acute coronary syndrome) were recorded during a 12-month follow-up. Baseline platelet function measurements were similar in both groups. After 7 days

percent inhibitions of maximum platelet aggregation and late platelet aggregation were significantly greater in the triple versus dual group (42.3%±16.0% vs. 20.8%±15.2%

P<0.01

and 54.7%±18.3% vs. 21.5%±29.2%

P<0.01

respectively). During the 12-month follow-up

the rate of subsequent MACE (6/45) was significantly lower in the triple group compared with the dual group (14/45; P<0.05). Adjunctive NXT to maintenance dose clopidogrel (75 g) could enhance the antiplatelet effect and decrease subsequent MACE in patients with the CYP2C19*2 polymorphism undergoing PCI.

Abstract

To determine the impact of adjunctive Buchang Naoxintong Capsule (步长脑心通胶囊

and their genotypes were confirmed by polymerase chain reaction (PCR). The patients were randomly assigned to receive either adjunctive NXT (triple group

45 cases) or dual antiplatelet therapy (dual group

including sudden cardiac arrest and acute coronary syndrome) were recorded during a 12-month follow-up. Baseline platelet function measurements were similar in both groups. After 7 days

percent inhibitions of maximum platelet aggregation and late platelet aggregation were significantly greater in the triple versus dual group (42.3%±16.0% vs. 20.8%±15.2%

P<0.01

and 54.7%±18.3% vs. 21.5%±29.2%

P<0.01

respectively). During the 12-month follow-up

关键词

PlateletCYP2C19*2 gene mutationBuchang Naoxintong Capsulemaintenance dose clopidogrelclinical prognosisChinese Medicinerandomized controlled trial

Keywords

PlateletCYP2C19*2 gene mutationBuchang Naoxintong Capsulemaintenance dose clopidogrelclinical prognosisChinese Medicinerandomized controlled trial

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Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

The First Hospital of Beijing University of Chinese Medicine

Department of Dermatology, China-Japan Friendship Hospital, Beijng

Janssen Pharmaceutical Ltd., Beijing

Department of Medical Statistics, School of Public Health, Sun Yat-sen University

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