Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state

Hai-ming Wang; Ming-hui Yang; Yi Liu; Shao-dan Li; Min Li

doi:10.1007/s11655-014-2029-6

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Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state

Updated：2021-08-27

- Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state
- Chinese Journal of Integrative Medicine Vol. 20, Issue 12, Pages: 944-948(2014)
- Affiliations：
  
  Department of Traditional Chinese Medicine, PLA General Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 30672762)
- DOI：10.1007/s11655-014-2029-6
  CLC：
- Published：2014，
  
  Published Online：27 November 2014，
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Wang, Hm., Yang, Mh., Liu, Y. et al. Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state., Chin. J. Integr. Med. 20, 944–948 (2014). https://doi.org/10.1007/s11655-014-2029-6

Hai-ming Wang, Ming-hui Yang, Yi Liu, et al. Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state. [J]. Chinese Journal of Integrative Medicine 20(12):944-948(2014)
Wang, Hm., Yang, Mh., Liu, Y. et al. Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state., Chin. J. Integr. Med. 20, 944–948 (2014). https://doi.org/10.1007/s11655-014-2029-6 DOI：

Hai-ming Wang, Ming-hui Yang, Yi Liu, et al. Effectiveness of Bushen Huoxue Granule (补肾活血颗粒) on 5-serotonin and norepinephrine in the brain of Parkinson’s disease patients with depressive state. [J]. Chinese Journal of Integrative Medicine 20(12):944-948(2014) DOI： 10.1007/s11655-014-2029-6.

摘要

To observe the clinical curative effect of Chinese medicine Bushen Huoxue Granule(补肾活血颗粒

BHG) on Parkinson’s disease (PD) patients with depressive state. Sixty-two PD patients with depressive state were randomly assigned to two groups by using a random number table

31 in each group. Madopar was given to all as the conventional treatment. The fluoxetine hydrochloride dispersible tablet was given to the patients in the control group and BHG was given to those in the treatment group. The therapeutic course for all was 12 weeks. Before and after treatment

Hamilton depression rating scale (HAMD) was applied to judge the curative effect

and the changes of cerebral neurotransmitters levels in the brain of patients were detected by encephalofluctuograph technique. The scores of HAMD in the two groups were decreased markedly after 12-week treatment. It was lower in the treatment group than that in the control group with significant difference (P<0.01). The contents of norepinephrine (NE) and 5-serotonin (5-HT) in the PD patients were obviously lower than normal value. There was no significant difference between the two groups before treatment (P>0.05). The contents of NE and 5-HT were all increased in the two groups after treatment (P<0.05)

with significant differences between the two groups (P<0.01). BHG could increase the contents of NE and 5-HT in PD patients’ brain to improve the depressive state of PD patients.

Abstract

To observe the clinical curative effect of Chinese medicine Bushen Huoxue Granule(补肾活血颗粒

BHG) on Parkinson’s disease (PD) patients with depressive state. Sixty-two PD patients with depressive state were randomly assigned to two groups by using a random number table

Hamilton depression rating scale (HAMD) was applied to judge the curative effect

with significant differences between the two groups (P<0.01). BHG could increase the contents of NE and 5-HT in PD patients’ brain to improve the depressive state of PD patients.

关键词

Parkinson’s diseaseBushen Huoxue Granuledepressive statecerebral neurotransmittersChinese Medicine

Keywords

Parkinson’s diseaseBushen Huoxue Granuledepressive statecerebral neurotransmittersChinese Medicine

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Institute of Traditional Chinese Medicine, General Hospital of PLA

Department of Neurology, Shanghai Tong-Ren Hospital, Shanghai Jiao Tong University School of Medicine

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School of Chinese Medicine, the University of Hong Kong

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