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Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing
- Chinese Journal of Integrative Medicine Vol. 23, Issue 4, Pages: 261-269(2017)
- Affiliations：
1. School of Pharmacy, Nanjing University of Chinese Medicine,Nanjing,China
2. Research Center of Traditional Chinese Medicine Processing Technology, Zhejiang Chinese Medical University,Hangzhou,China
3. Zhejiang Cancer Hospital,Hangzhou,China
- Author bio：
- Funds：Supported by the National Natural Science Foundation of China (No. 81173546 and No. 30940093), the Natural Science Foundation of Jiangsu Province, China (No. BK2009495), the International Science and Technology Cooperation Project of Jiangsu Province, China (No. BZ2011053), the Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, No. 2011ZYX2-001), the Postgraduate Research Innovation Project of Jiangsu Higher Education Institutions (No. KYLX_0975), the Chinese Medicine Research Program of Zhejiang Province, China (No. 2014ZQ008), and the Science Foundation of Zhejiang Chinese Medical University (No. 2013ZZ12)
DOI：10.1007/s11655-015-1966-z
CLC：Published：2017，
Published Online：24 March 2015，
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Cai, H., Cao, G. & Zhang, Hy. Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing., Chin. J. Integr. Med. 23, 261–269 (2017). https://doi.org/10.1007/s11655-015-1966-z
Hao Cai, Gang Cao, Hong-yan Zhang. Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing. [J]. Chinese Journal of Integrative Medicine 23(4):261-269(2017)
Cai, H., Cao, G. & Zhang, Hy. Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing., Chin. J. Integr. Med. 23, 261–269 (2017). https://doi.org/10.1007/s11655-015-1966-z DOI：
Hao Cai, Gang Cao, Hong-yan Zhang. Qualitative analysis of a sulfur-fumigated Chinese herbal medicine by comprehensive two-dimensional gas chromatography and high-resolution time of flight mass spectrometry using colorized fuzzy difference data processing. [J]. Chinese Journal of Integrative Medicine 23(4):261-269(2017) DOI： 10.1007/s11655-015-1966-z.
摘要
To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis. A comprehensive two-dimensional gas chromatography (GC×GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis. Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples. Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis. The strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis. GC×GC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines.
Abstract
To investigate the chemical transformation of volatile compounds in sulfur-fumigated Radix Angelicae Sinensis. A comprehensive two-dimensional gas chromatography (GC×GC) and high-resolution time-of-flight mass spectrometry (HR-TOF/MS) with colorized fuzzy difference (CFD) method was used to investigate the effect of sulfur-fumigation on the volatile components from Radix Angelicae Sinensis. Twenty-five compounds that were found in sun-dried samples disappeared in sulfur-fumigated samples. Seventeen volatile components including two sulfur-containing compounds were newly generated for the first time in volatile oils of sulfur-fumigated Radix Angelicae Sinensis. The strategy can be successfully applied to rapidly and holistically discriminate sun-dried and sulfur-fumigated Radix Angelicae Sinensis. GC×GC-HR-TOF/MS based CFD is a powerful and feasible approach for the global quality evaluation of Radix Angelicae Sinensis as well as other herbal medicines.
关键词
Radix Angelicae Sinensiscomprehensive two-dimensional gas chromatography and high-resolution time-of-flight mass spectrometrycolorized fuzzy differencevolatile components
Keywords
Radix Angelicae Sinensiscomprehensive two-dimensional gas chromatography and high-resolution time-of-flight mass spectrometrycolorized fuzzy differencevolatile components
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