Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis

Chun-song Yang; Yun-zhu Lin; Qin Guo; Li-li He

doi:10.1007/s11655-015-1974-z

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Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis

Updated：2021-08-27

- Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis
- Chinese Journal of Integrative Medicine Vol. 24, Issue 2, Pages: 147-155(2018)
- Affiliations：
  
  1. Department of Pharmacy, Evidence-Based Pharmacy Centre, West China Second Hospital, Sichuan University,Chengdu,China
  2. West China Second Hospital, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University,Chengdu,China
  3. Department of Pediatrics, West China Second Hospital, Sichuan University,Chengdu,China
  4. College of Chemistry and Environment Protection, Southwest University for Nationalities,Chengdu,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373381)
- DOI：10.1007/s11655-015-1974-z
  CLC：
- Published：2018，
  
  Published Online：12 May 2015，
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Yang, Cs., Lin, Yz., Guo, Q. et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis., Chin. J. Integr. Med. 24, 147–155 (2018). https://doi.org/10.1007/s11655-015-1974-z

Chun-song Yang, Yun-zhu Lin, Qin Guo, et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 24(2):147-155(2018)
Yang, Cs., Lin, Yz., Guo, Q. et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis., Chin. J. Integr. Med. 24, 147–155 (2018). https://doi.org/10.1007/s11655-015-1974-z DOI：

Chun-song Yang, Yun-zhu Lin, Qin Guo, et al. Chinese Herbal Medicine Xingnaojing Injection (醒脑静注射液) for Hypoxic Ischemic Encephalopathy in Newborns: A Systematic Review and Meta-Analysis. [J]. Chinese Journal of Integrative Medicine 24(2):147-155(2018) DOI： 10.1007/s11655-015-1974-z.

摘要

To evaluate the efficacy and safety of Chinese herbal medicine Xingnaojing Injection (醒脑静注射液) for newborns with hypoxic ischemic encephalopathy (HIE). Literatures were identified by searching the PubMed

EMBASE

Cochrane Library

Cochrane Central

and four Chinese literature databases from the establishment of database to October in 2013. Relevant reference lists were also screened. Two reviewers independently evaluated the methodological quality of included studies. We also conducted the meta-analysis. Thirteen trials involving 1

169 patients were included. There was no trial reported death or disability at the end of follow-up period. Meta-analysis of 4 trials (n=371) showed that there was no significant difference in the reduction of mortality [risk ratios (RR)=0.48

95% confidence intervals (CI

0.21

1.13)

P=0.09] between the Xingnaojing and control groups. Meta-analysis of 5 trials (n=359) showed that there was significant difference in reducing the major neurodevelopmental disability [RR=0.36

95% CI (0.19

0.66)

P=0.001]. Meta-analysis of 6 trials (n=447) showed that there was significant difference in the author self-defined symptom improvement [RR=1.25

95% CI (1.14

1.37)

P<0.01]. No fatal side-effects were reported. Based on the limited evidence

the routine use of Xingnaojing Injection for treatment of HIE in newborns is not recommended. Further well-conducted trials are justified.

Abstract

EMBASE

Cochrane Library

Cochrane Central

95% confidence intervals (CI

0.21

1.13)

P=0.09] between the Xingnaojing and control groups. Meta-analysis of 5 trials (n=359) showed that there was significant difference in reducing the major neurodevelopmental disability [RR=0.36

95% CI (0.19

0.66)

P=0.001]. Meta-analysis of 6 trials (n=447) showed that there was significant difference in the author self-defined symptom improvement [RR=1.25

95% CI (1.14

1.37)

P<0.01]. No fatal side-effects were reported. Based on the limited evidence

the routine use of Xingnaojing Injection for treatment of HIE in newborns is not recommended. Further well-conducted trials are justified.

关键词

Chinese Herbal MedicinenewbornsHypoxic Ischemic Encephalopathysystematic review

Keywords

Chinese Herbal MedicinenewbornsHypoxic Ischemic Encephalopathysystematic review

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