Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations

Chi Zhang; Miao Jiang; Xiao-juan He; Ai-ping Lu

doi:10.1007/s11655-015-2041-5

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Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations

Updated：2021-08-27

- Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations
- Chinese Journal of Integrative Medicine Vol. 21, Issue 6, Pages: 403-407(2015)
- Affiliations：
  
  1. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences,Beijing,China
  2. Hong Kong Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University,Hong Kong SAR,China
- Author bio：
- Funds：
  
  Supported by China Academy of Chinese Medical Sciences Project (No. Z0218, Z0252, Z0293)
- DOI：10.1007/s11655-015-2041-5
  CLC：
- Published：2015，
  
  Published Online：11 June 2015，
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Zhang, C., Jiang, M., He, Xj. et al. Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations., Chin. J. Integr. Med. 21, 403–407 (2015). https://doi.org/10.1007/s11655-015-2041-5

Chi Zhang, Miao Jiang, Xiao-juan He, et al. Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations. [J]. Chinese Journal of Integrative Medicine 21(6):403-407(2015)
Zhang, C., Jiang, M., He, Xj. et al. Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations., Chin. J. Integr. Med. 21, 403–407 (2015). https://doi.org/10.1007/s11655-015-2041-5 DOI：

Chi Zhang, Miao Jiang, Xiao-juan He, et al. Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations. [J]. Chinese Journal of Integrative Medicine 21(6):403-407(2015) DOI： 10.1007/s11655-015-2041-5.

摘要

Controlled clinical trials of integrative therapies available to patients with rheumatoid arthritis (RA) improved dramatically in the past 20 years

largely because of the growing need and the methodologies improvement. Tripterygium wilfordii Hook. F.

a typical example of popular use herb

has been extensively studied in trials. However

clear and convincing evidence of integrative therapy

effectiveness and safety

remains insufficient to make decision. Many research efforts are hampered by standing problems with ‘syndrome’ recruitment failure. In addition

the outcome multiplicity induces the findings inefficiency to generalize to RA patients at large. Development of validated syndrome outcomes and methodologies has also been critical. Current efforts to enhance the understanding of integrative treatment options for patients with RA include the development of drug-specific rather than disease-specific strategies

studies in predictive biomarkers

and development of peer-review trial protocol for regular clinical trials.

Abstract

Controlled clinical trials of integrative therapies available to patients with rheumatoid arthritis (RA) improved dramatically in the past 20 years

largely because of the growing need and the methodologies improvement. Tripterygium wilfordii Hook. F.

a typical example of popular use herb

has been extensively studied in trials. However

clear and convincing evidence of integrative therapy

effectiveness and safety

remains insufficient to make decision. Many research efforts are hampered by standing problems with ‘syndrome’ recruitment failure. In addition

studies in predictive biomarkers

and development of peer-review trial protocol for regular clinical trials.

关键词

clinical trialrheumatoid arthritisIntegrative Medicinereview

Keywords

clinical trialrheumatoid arthritisIntegrative Medicinereview

references

Lv QW, Zhang W, Shi Q, Zheng WJ, Li X, Chen H, et al. Comparison of Tripterygium wilfordii Hook F with methotrexate in the treatment of active rheumatoid arthritis (TRIFRA): a randomised, controlled clinical trial. Ann Rheum Dis 2014.

Colmegna I, Ohata BR, Menard HA. Current understanding of rheumatoid arthritis therapy. Clin Pharmacol Therapeut 2012;91:607–620.

Moudgil KD, Berman BM. Traditional Chinese medicine: potential for clinical treatment of rheumatoid arthritis. Expert Rev Clin Immunol 2014;10:819–822.

Alaaeddine N, Okais J, Ballane L, Baddoura RM. Use of complementary and alternative therapy among patients with rheumatoid arthritis and osteoarthritis. J Clin Nurs 2012;21:3198–3204.

Zeng XF, Zhu SL, Tan AC, Xie XP. Disease burden and quality of life of rheumatoid arthritis in China: a systematic review. Chin J Evid Based Med (Chin) 2013;13:300–307.

Paul JR, Ranganathan P. Clinical trials in rheumatoid arthritis: a status report from the ClinicalTrials. gov website. Rheumatol Int 2012;32:1831–1835.

Shi CN. Clinical use of Tripterygium wilfordii Hook F. Herald Med (Chin) 1988;4:8–9.

Guo JL, Yuan SX, Wang XC, Xu SX, Li DD. Clinical observation of Tripterygium wilfordii Hook F for rheumatoid arthritis (Abstract). Bull Med Res (Chin) 1980;9:2.

Tao X, Younger J, Fan FZ, Wang B, Lipsky PE. Benefit of an extract of Tripterygium wilfordii Hook F in patients with rheumatoid arthritis: a double-blind, placebo-controlled study. Arthr Rheum 2002;46:1735–1743.

Goldbach-Mansky R, Wilson M, Fleischmann R, Olsen N, Silverfield J, Kempf P, et al. Comparison of Tripterygium wilfordii Hook F versus sulfasalazine in the treatment of rheumatoid arthritis: a randomized trial. Ann Intern Med 2009;151:229–240.

Alarcóan GS, Tracy IC, Blackburn WD. Methotrexate in rheumatoid arthritis. Toxic effects as the major factor in limiting long-term treatment. Arthr Rheum 1989;32:671–676.

Liu J, Sun Y. How does Chinese medicine target cytokine imbalance in rheumatoid arthritis? Chin J Integr Med 2013;19:874–880.

Chen BJ. Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F. Leuk Lymphom 2001;42:253–265.

Li J, Lu Y, Xiao C, Lu C, Niu X, He X, et al. Comparison of toxic reaction of Tripterygium wilfordii multiglycoside in normal and adjuvant arthritic rats. J Ethnopharmacol 2011;135:270–277.

Chen M, Ni Y, Duan H, Qiu Y, Guo C, Jiao Y, et al. Mass spectrometry-based metabolic profiling of rat urine associated with general toxicity induced by the multiglycoside of Tripterygium wilfordii Hook. f. Chemic Res Toxicol (Chin) 2008;21:288–294.

Ding ZH, Wang HF, Gui ZH, Ding D, Ye YP, Lin HP. Efficacy of Chinese integrative medicine for rheumatoid arthritis: a meta-analysis. Chin Remed Clin (Chin) 2013;13:1184–1185.

Guo XJ, Li S, Huang YS. Total glucosides of paeony as adjunct therapy for the treatment of rheumatoid arthritis: a meta-analysis. J Jinggangshan Univ (Natural Sci, Chin) 2013;34:83–87.

Jiang Q, Cao W, Tang XP, Jiao J. Extracts of Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: a systemic review. China J Chin Mater Med (Chin) 2009;34:2637–2643.

Jiang Q, Cao W, Tang XP, Jiao J. Compound Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: a systemic review. Lishizhen Med Mater Med Res (Chin) 2009;20:2378–2378.

Li RC, Feng ZT, Wang JG, Ren J, Li J. Meta-Analysis of combined Chinese and Western medicine in the treatment of rheumatoid arthritis. China Med Herald (Chin) 2011;8:94–96.

Li RC, Li J. System review of Zhengqing Fengtongning and methotrexate on treatment of rheumatoid arthritis. China J Exp Tradit Med Formul (Chin) 2012;18:1–4.

Liu YF, Tu SH, Gao WN, Wang Y, Liu PL, Hu YH, et al. Extracts of Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: a systemic review and meta-analysis of randomised controlled trials. Evid Based Complement Alternat Med 2013;2013:410793.

Shang W, Guo JH, Cai H. Meta-analysis of total glucosides of paeony combined with methotrexate in treatment for rheumatoid arthritis. Modern J Integr Tradit Chin West Med (Chin) 2010;19:653–656.

Shen W. Effects of Chinese herb clearing heat and removing dampness combining with Western medicine on rheumatoid arthritis patients in active phase: a systematic review. Chengdu: Chengdu University of Traditional Chinese Medicine;2010.

Tang SY, Zhao YS, Zhao LX, Chen S, Guo YY. Efficacy and safety of Tripterygium wilfordii Hook F in the treatment of rheumatoid arthritis: a systemic review. Shandong Med J (Chin) 2010;50:44–46.

Tian X, Yan MY, Wang WG. Meta analysis of external therapies of traditional Chinese medicine in treating rheumatoid arthritis. China J Tradit Chin Med Pharm (Chin) 2014;10:3282–3285.

Wang JQ, Li GC, Zhou XP, Feng Z. Tripterygium wilfordii extraction for treating rheumatoid arthritis: a metaanalysis. Modern J Integr Tradit Chin West Med (Chin) 2014;23:1032–1035.

Yang MY, Wang JS, Xie YH, Zhang HN. Efficacy and safety of Chinese herbal medicine in the treatment of rheumatoid arthritis: a systemic review. Beijing J Tradit Chin Med (Chin) 2009;28:497–500.

Yu C. The systematic review of the recent efficacy for the treatment of rheumatoid arthritis with Chinese herbal alone or Chinese herbal with Western medicine. Chengdu: Chengdu University of Traditional Chinese Medicine;2009.

Zhang C, Jiang M, Lu AP. Chinese herbal medicines versus disease modifying antirheumatic drugs for management of rheumatoid arthritis: a systematic review. Eur J Integr Med 2011;3:e219–e231.

Zhang J, Wei W, Ji HY, Wang CM. Efficacy and safety of Zhengqing Fengtongning and biomedicine for rheumatoid arthritis: a systemic review. Tianjin Med J (Chin) 2012;40:1062–1066.

Zhong X, Su N, Zhou SH, Yang NP, Xie ZG. Metaanalysis of the efficacy and safety of total glucosides of paeony combined with immunosuppressant in the treatment of rheumatoid arthritis. China Pharm (Chin) 2010;39:3731–3734.

Pocock SJ. Clinical trials: a practical approach. New York: Wiley Chichester;1983:1–3.

Jüni P, Altman DG, Egger M. Assessing the quality of controlled clinical trials. BMJ 2001;323:42–46.

Zhao XX, Qin B. The situation and estimate of literature diagnosis and treat criterion about the traditional Chinese medicinal treatment in rheumatoid arthritis. Chin Arch Tradit Chin Med (Chin) 2009;27:1879–1880.

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