Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials

Yi-wen Che; Ke-yu Yao; Yu-peng Xi; Zi-jie Chen; Yong-le Li; Ning Yu; Shuang-qing Zhai

doi:10.1007/s11655-015-2047-z

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Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials

Updated：2021-08-27

- Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials
- Chinese Journal of Integrative Medicine Vol. 22, Issue 4, Pages: 302-310(2016)
- Affiliations：
  
  School of Basic Medical Sciences, Beijing University of Chinese Medicine,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Specialized Research Fund for the Doctoral Program of Higher Education (No. 20120013110002)
- DOI：10.1007/s11655-015-2047-z
  CLC：
- Published：2016，
  
  Published Online：6 April 2015，
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Che, Yw., Yao, Ky., Xi, Yp. et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 302–310 (2016). https://doi.org/10.1007/s11655-015-2047-z

Yi-wen Che, Ke-yu Yao, Yu-peng Xi, et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 22(4):302-310(2016)
Che, Yw., Yao, Ky., Xi, Yp. et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials., Chin. J. Integr. Med. 22, 302–310 (2016). https://doi.org/10.1007/s11655-015-2047-z DOI：

Yi-wen Che, Ke-yu Yao, Yu-peng Xi, et al. Wendan decoction (温胆汤) for treatment of schizophrenia: a systematic review of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 22(4):302-310(2016) DOI： 10.1007/s11655-015-2047-z.

摘要

To assess the beneficial and adverse effects of Wendan Decoction (温胆汤

WDD) for the treatment of schizophrenia. Five electronic databases were searched until May 2014

including the Chinese National Knowledge Infrastructure

the Chinese Biomedical Literature Database

the Chinese Scientist Journal Database

PubMed

and the Cochrane Central Register of Controlled Trials in the Cochrane Library. The randomized controlled trials (RCTs) testing WDD against placebo

antipsychotic drugs

or WDD combined with antipsychotic drugs against antipsychotic drugs alone were included. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. Thirteen RCTs (involving 1

174 patients) were included and the methodological quality was evaluated as generally low. The pooled results showed that WDD combined with antipsychotic drugs were more effective in clinical comprehensive effect

Positive and Negative Syndrome Scale (PANSS) scores and Brief Psychiatric Rating Scale scores compared with antipsychotic drugs alone. However

WDD had less effectiveness compared with antipsychotics in clinical comprehensive effect; and WDD was not different from antipsychotic drugs for PANSS scores. The side effects were significantly reduced in the intervention group compared with the control group. WDD appears to be effective on improving symptoms in patients with schizophrenia. However

due to poor methodological quality in the majority of the included trials

the potential benefit from WDD needs to be confirmed in rigorous trials and the design and reporting of trials should follow the international standards.

Abstract

To assess the beneficial and adverse effects of Wendan Decoction (温胆汤

WDD) for the treatment of schizophrenia. Five electronic databases were searched until May 2014

including the Chinese National Knowledge Infrastructure

the Chinese Biomedical Literature Database

the Chinese Scientist Journal Database

PubMed

and the Cochrane Central Register of Controlled Trials in the Cochrane Library. The randomized controlled trials (RCTs) testing WDD against placebo

antipsychotic drugs

or WDD combined with antipsychotic drugs against antipsychotic drugs alone were included. Study selection

data extraction

quality assessment

and data analyses were conducted according to the Cochrane standards. Thirteen RCTs (involving 1

Positive and Negative Syndrome Scale (PANSS) scores and Brief Psychiatric Rating Scale scores compared with antipsychotic drugs alone. However

due to poor methodological quality in the majority of the included trials

the potential benefit from WDD needs to be confirmed in rigorous trials and the design and reporting of trials should follow the international standards.

关键词

Wendan Decoctionschizophreniarandomized controlled trialsystematic review

Keywords

Wendan Decoctionschizophreniarandomized controlled trialsystematic review

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Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences

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