Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice

Zhe-wei Fei; Xi-ping Zhang; Jie Zhang; Xin-mei Huang; Di-jiong Wu; Hong-hao Bi

doi:10.1007/s11655-015-2048-y

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Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice

Updated：2021-08-27

- Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice
- Chinese Journal of Integrative Medicine Vol. 22, Issue 9, Pages: 674-684(2016)
- Affiliations：
  
  1. Department of General Surgery, Xinhua Hospital, Chongming Branch, School of Medicine, Shanghai Jiao Tong University,Shanghai,China
  2. Department of Breast Surgery, Zhejiang Cancer Hospital,Hangzhou,China
  3. First College of Clinical Medicine, Zhejiang Chinese Medical University,Hangzhou,China
  4. Department of Genetics, Development, and Cell Biology, Iowa State University, Ames,USA
- Author bio：
- Funds：
  
  Supported by the Foundation Project for Technology of Hangzhou, China (No. 2005224)
- DOI：10.1007/s11655-015-2048-y
  CLC：
- Published：2016，
  
  Published Online：6 April 2015，
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Fei, Zw., Zhang, Xp., Zhang, J. et al. Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice., Chin. J. Integr. Med. 22, 674–684 (2016). https://doi.org/10.1007/s11655-015-2048-y

Zhe-wei Fei, Xi-ping Zhang, Jie Zhang, et al. Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice. [J]. Chinese Journal of Integrative Medicine 22(9):674-684(2016)
Fei, Zw., Zhang, Xp., Zhang, J. et al. Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice., Chin. J. Integr. Med. 22, 674–684 (2016). https://doi.org/10.1007/s11655-015-2048-y DOI：

Zhe-wei Fei, Xi-ping Zhang, Jie Zhang, et al. Protective effects of Radix Astragali injection on multiple organs of rats with obstructive jaundice. [J]. Chinese Journal of Integrative Medicine 22(9):674-684(2016) DOI： 10.1007/s11655-015-2048-y.

摘要

To investigate the protective effects and mechanisms of Radix Astragali Injection on multiple organs of rats with obstructive jaundice (OJ). A total of 180 rats were randomly divided into the sham-operated

model control and treated groups (60 in each group). On 7

21 and 28 days after operation

the serum contents of alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

r-glutamyl transpeptidase (r-GT)

total bilirubin (TBil)

direct bilirubin (DBil)

blood urine nitrogen (BUN)

and creatinine (CREA) were determined. And the pathological changes of livers

kidneys and lungs

and protein expressions of toll-like receptor-4 (TLR-4) of livers

intercellular adhesion molecule-1 (ICAM-1) of lungs

Bax and nuclear factor-kappa B (NF-κB)

as well as apoptotic indexes of multiple organs were observed

respectively. The pathological severity scores of multiple organs (including livers on 7

21 and 28 days

kidneys on 14 and 28 days

and lungs on 14 days)

serum contents of ALT (14 and 21 days)

AST (14 days)

TBil (7

21 and 28 days)

DBil (14 and 21 days)

BUN (28 days)

protein expressions of TLR-4 (in livers

28 days)

Bax (in livers and kidneys

21 days)

and apoptotic indexes in livers (7 and 21 days) in the treated group were significantly lower than those in the model control group (P<0.05 or P<0.01). Radix Astragali Injection exerts protective effects on multiple organs of OJ rats by improving the pathological changes of lung

liver and kidney

decreasing the serum index of hepatic and renal function as well as inhibiting the protein expression of TLR-4 and Bax in the livers and Bax in the kidneys.

Abstract

model control and treated groups (60 in each group). On 7

21 and 28 days after operation

the serum contents of alanine aminotransferase (ALT)

aspartate aminotransferase (AST)

r-glutamyl transpeptidase (r-GT)

total bilirubin (TBil)

direct bilirubin (DBil)

blood urine nitrogen (BUN)

and creatinine (CREA) were determined. And the pathological changes of livers

kidneys and lungs

and protein expressions of toll-like receptor-4 (TLR-4) of livers

intercellular adhesion molecule-1 (ICAM-1) of lungs

Bax and nuclear factor-kappa B (NF-κB)

as well as apoptotic indexes of multiple organs were observed

respectively. The pathological severity scores of multiple organs (including livers on 7

21 and 28 days

kidneys on 14 and 28 days

and lungs on 14 days)

serum contents of ALT (14 and 21 days)

AST (14 days)

TBil (7

21 and 28 days)

DBil (14 and 21 days)

BUN (28 days)

protein expressions of TLR-4 (in livers

28 days)

Bax (in livers and kidneys

21 days)

liver and kidney

decreasing the serum index of hepatic and renal function as well as inhibiting the protein expression of TLR-4 and Bax in the livers and Bax in the kidneys.

关键词

Radix Astragali Injectionobstructive jaundicemultiple organ dysfunctionapoptosisimmunohistochemistrytissue microarrayChinese Medicine

Keywords

Radix Astragali Injectionobstructive jaundicemultiple organ dysfunctionapoptosisimmunohistochemistrytissue microarrayChinese Medicine

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