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Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial
- Chinese Journal of Integrative Medicine Vol. 21, Issue 11, Pages: 855-865(2015)
- Affiliations：
1. Yueyang Clinical School of Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai,China
2. Medical Imaging Department, Jinhua Municipal Central Hospital,Zhejiang Province,Jinhua,China
3. Department of Acupuncture and Moxibustion, Jinhua Municipal Central Hospital,Zhejiang Province,Jinhua,China
4. Department of Digestive System, Jinhua Municipal Central Hospital,Zhejiang Province,Jinhua,China
5. Radiology Department, Huashan Hospital, Fudan University,Shanghai,China
6. Department of Anatomy and Cell Biology, Indiana University School of Medicine,Indianapolis,USA
7. Shanghai Research Institute of Acupuncture and Meridian, Shanghai University of Traditional Chinese Medicine,Shanghai,China
- Author bio：
- Funds：
DOI：10.1007/s11655-015-2049-x
CLC：Published：2015，
Published Online：6 April 2015，
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Zhao, Jm., Lu, Jh., Yin, Xj. et al. Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial., Chin. J. Integr. Med. 21, 855–865 (2015). https://doi.org/10.1007/s11655-015-2049-x
Ji-meng Zhao, Jin-hua Lu, Xiao-jun Yin, et al. Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 21(11):855-865(2015)
Zhao, Jm., Lu, Jh., Yin, Xj. et al. Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial., Chin. J. Integr. Med. 21, 855–865 (2015). https://doi.org/10.1007/s11655-015-2049-x DOI：
Ji-meng Zhao, Jin-hua Lu, Xiao-jun Yin, et al. Comparison of electroacupuncture and moxibustion on brain-gut function in patients with diarrhea-predominant irritable bowel syndrome: A randomized controlled trial. [J]. Chinese Journal of Integrative Medicine 21(11):855-865(2015) DOI： 10.1007/s11655-015-2049-x.
摘要
To compare the effects of electroacupuncture (EA) and moxibustion therapies on patients with diarrhea-predominant irritable bowel syndrome (D-IBS). A total of 60 D-IBS patients were randomly allocated to the EA group (30 cases) and moxibustion group (30 cases). Before and after treatment
the gastrointestinal symptoms and psychological symptoms were scored by Visual Analogue Scale
Bristol Stool Form Scale
Hamilton Anxiety Rating Scale (HAMA)
and Hamilton Depression Rating Scale (HAMD); the expressions of 5-hydroxytryptamine (5-HT)
5-HT3 receptor (5-HT3R)
and 5-HT4 receptor (5-HT4R) in the sigmoid mucosal tissue were measured by immunohistochemical staining. Additionally
the effects on the functional brain areas of the anterior cingulate cortex (ACC)
insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging. Compared with before treatment
both EA and moxibustion groups reported significant improvements in abdominal pain and abdominal bloating after treatment (P<0.01 or P<0.05). The moxibustion group reported greater improvements in defecation emergency
defecation frequency
and stool feature than the EA group (P<0.01). Both HAMA and HAMD scores were significantly decreased in the moxibustion group than in the EA group (P<0.01). Both groups demonstrated signifificantly reduced expressions of 5-HT
5-HT3R and 5-HT4R in the colonic mucosa after treatment (P<0.01)
with a greater reduction of 5-HT in the moxibustion group (P<0.05). Finally
decreased activated voxel values were observed in the left IC
right IC and PFC brain regions of patients in the moxibustion group under stimulation with 150 mL colorectal distension after treatment (P<0.05 or P<0.01)
while in the EA group only PFC area demonstrated a reduction (P<0.05). Moxibustion can signifificantly improve the symptoms of D-IBS
suggesting that moxibustion may be a more effective therapy than EA for D-IBS patients.
Abstract
To compare the effects of electroacupuncture (EA) and moxibustion therapies on patients with diarrhea-predominant irritable bowel syndrome (D-IBS). A total of 60 D-IBS patients were randomly allocated to the EA group (30 cases) and moxibustion group (30 cases). Before and after treatment
the gastrointestinal symptoms and psychological symptoms were scored by Visual Analogue Scale
Bristol Stool Form Scale
Hamilton Anxiety Rating Scale (HAMA)
and Hamilton Depression Rating Scale (HAMD); the expressions of 5-hydroxytryptamine (5-HT)
5-HT3 receptor (5-HT3R)
and 5-HT4 receptor (5-HT4R) in the sigmoid mucosal tissue were measured by immunohistochemical staining. Additionally
the effects on the functional brain areas of the anterior cingulate cortex (ACC)
insular cortex (IC) and prefrontal cortex (PFC) were observed by functional magnetic resonance imaging. Compared with before treatment
both EA and moxibustion groups reported significant improvements in abdominal pain and abdominal bloating after treatment (P<0.01 or P<0.05). The moxibustion group reported greater improvements in defecation emergency
defecation frequency
and stool feature than the EA group (P<0.01). Both HAMA and HAMD scores were significantly decreased in the moxibustion group than in the EA group (P<0.01). Both groups demonstrated signifificantly reduced expressions of 5-HT
5-HT3R and 5-HT4R in the colonic mucosa after treatment (P<0.01)
with a greater reduction of 5-HT in the moxibustion group (P<0.05). Finally
decreased activated voxel values were observed in the left IC
right IC and PFC brain regions of patients in the moxibustion group under stimulation with 150 mL colorectal distension after treatment (P<0.05 or P<0.01)
while in the EA group only PFC area demonstrated a reduction (P<0.05). Moxibustion can signifificantly improve the symptoms of D-IBS
suggesting that moxibustion may be a more effective therapy than EA for D-IBS patients.
关键词
Irritable Bowel SyndromeDiarrheamoxibustionelectroacupuncturerandomized controlled trial
Keywords
Irritable Bowel SyndromeDiarrheamoxibustionelectroacupuncturerandomized controlled trial
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