Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest

Da Zhang; Chun-sheng Li; Zhi-jun Guo; Wen-peng Yin; Xiao-min Hou

doi:10.1007/s11655-015-2077-6

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Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest

Updated：2021-08-27

- Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest
- Chinese Journal of Integrative Medicine Vol. 22, Issue 5, Pages: 370-376(2016)
- Affiliations：
  
  Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University,Beijing,China
- Author bio：
- Funds：
  
  Supported by the Beijing Natural Science Foundation (No. 7132092) and Beijing Scientific Research Project for Outstanding Doctoral Thesis Guidance Teacher (No. 20121002501)
- DOI：10.1007/s11655-015-2077-6
  CLC：
- Published：2016，
  
  Published Online：6 March 2015，
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Zhang, D., Li, Cs., Guo, Zj. et al. Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest., Chin. J. Integr. Med. 22, 370–376 (2016). https://doi.org/10.1007/s11655-015-2077-6

Da Zhang, Chun-sheng Li, Zhi-jun Guo, et al. Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest. [J]. Chinese Journal of Integrative Medicine 22(5):370-376(2016)
Zhang, D., Li, Cs., Guo, Zj. et al. Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest., Chin. J. Integr. Med. 22, 370–376 (2016). https://doi.org/10.1007/s11655-015-2077-6 DOI：

Da Zhang, Chun-sheng Li, Zhi-jun Guo, et al. Comparison of Shenfu Injection (参附注射液) and epinephrine on catecholamine levels in a porcine model of prolonged cardiac arrest. [J]. Chinese Journal of Integrative Medicine 22(5):370-376(2016) DOI： 10.1007/s11655-015-2077-6.

摘要

To compare the effects of Shenfu Injection (SFI) and epinephrine (EPI) on catecholamine levels in a porcine model of prolonged cardiac arrest (CA). After 8 min of untreated ventricular fibrillation

24 Wuzhishan miniature pigs were randomly assigned to one of the three groups (n=8 per group) and received central venous injection

respectively: SFI group (1 mL/kg)

EPI group (20 μg/kg EPI)

and normal saline (NS) group. Cardiac output (CO)

maximum rate of increase/decrease in left ventricular pressure (±dp/dt)

serum levels of EPI

norepinephrine (NE)

and dopamine (DA) were determined at baseline and at 0.5

and 4 h after restoration of spontaneous circulation. The duration of cardiopulmonary resuscitation was shorter in the EPI and SFI groups than in the NS group (P<0.05). The EPI level increased significantly after restoration of spontaneous circulation (ROSC) in all three groups

and was significantly different between the EPI group and the other two groups immediately after ROSC (both P<0.01)

but these differences gradually disappeared over time. There were no significant differences in NE or DA levels among the three groups

and there were no correlations between catecholamine levels and CO or dp/dt (P>0.05). SFI did not significantly affect endogenous catecholamine levels during cardiopulmonary resuscitation after prolonged ventricular fibrillation. However

SFI improved oxygen metabolism

and produced a better hemodynamic status compared with EPI. SFI might be a potentially vasopressor drug for the treatment of CA.

Abstract

To compare the effects of Shenfu Injection (SFI) and epinephrine (EPI) on catecholamine levels in a porcine model of prolonged cardiac arrest (CA). After 8 min of untreated ventricular fibrillation

24 Wuzhishan miniature pigs were randomly assigned to one of the three groups (n=8 per group) and received central venous injection

respectively: SFI group (1 mL/kg)

EPI group (20 μg/kg EPI)

and normal saline (NS) group. Cardiac output (CO)

maximum rate of increase/decrease in left ventricular pressure (±dp/dt)

serum levels of EPI

norepinephrine (NE)

and dopamine (DA) were determined at baseline and at 0.5

and was significantly different between the EPI group and the other two groups immediately after ROSC (both P<0.01)

but these differences gradually disappeared over time. There were no significant differences in NE or DA levels among the three groups

SFI improved oxygen metabolism

and produced a better hemodynamic status compared with EPI. SFI might be a potentially vasopressor drug for the treatment of CA.

关键词

cardiac arrestventricular fibrillationcardiopulmonary resuscitationcatecholamineShenfu Injection

Keywords

cardiac arrestventricular fibrillationcardiopulmonary resuscitationcatecholamineShenfu Injection

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Department of Emergency, Beijing Chao-Yang Hospital, Capital Medical University

Department of Hyperbaric Oxygen, Beijing Chao-Yang Hospital, Capital Medical University

Emergency Department of Beijing Chaoyang Hospital, Capital Medical University

Department of Emergency, the First Affiliated Hospital of Nanchang University

Department of Emergency, Beijing Chaoyang Hospital, Capital Medical University, Beijing Key Laboratory of Cardiopulmonarycerebral Resuscitation

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