Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial

Lei Wan; Jian Liu; Chuan-bing Huang; Yuan Wang; Xi Chen; Wan-dong Zhang; Gui-zhen Wang; Hai-xia Fan; Yao Ge; Rui-lian Chen; Yun-xiang Cao; Rui-kai Zong; Tian-yang Liu

doi:10.1007/s11655-015-2093-6

Your Location：

Home >

Browse articles >

Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial

Updated：2021-08-27

- Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial
- Chinese Journal of Integrative Medicine Vol. 22, Issue 3, Pages: 168-176(2016)
- Affiliations：
  
  Department of Rheumatology, The First Affiliated Hospital of Anhui University of Chinese Medicine,Hefei,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of China (No. 81403388, 81173211);Anhui Province Natural Science Fund Project of China (No. 1508085QH159);Key Discipline of Chinese Bi Disease Science Projects, State Administration of Traditional Chinese Medicine (No. [2009]30);Anhui College of Traditional Chinese Medicine Science and Technology Innovation Team Project (No. 2010TD005);and the Fund Supported by Anhui University of Chinese Medicine University (No. 2014qn025)
- DOI：10.1007/s11655-015-2093-6
  CLC：
- Published：2016，
  
  Published Online：27 January 2016，
Scan for full text
Wan, L., Liu, J., Huang, Cb. et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial., Chin. J. Integr. Med. 22, 168–176 (2016). https://doi.org/10.1007/s11655-015-2093-6

Lei Wan, Jian Liu, Chuan-bing Huang, et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 22(3):168-176(2016)
Wan, L., Liu, J., Huang, Cb. et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial., Chin. J. Integr. Med. 22, 168–176 (2016). https://doi.org/10.1007/s11655-015-2093-6 DOI：

Lei Wan, Jian Liu, Chuan-bing Huang, et al. Xinfeng Capsule (新风胶囊) for the treatment of rheumatoid arthritis patients with decreased pulmonary function — A randomized controlled clinical trial. [J]. Chinese Journal of Integrative Medicine 22(3):168-176(2016) DOI： 10.1007/s11655-015-2093-6.

摘要

To determine the effectiveness and safety of Xinfeng Capsules (新风胶囊

XFC) for the treatment of rheumatoid arthritis (RA) patients with decreased pulmonary function. This was a randomized controlled clinical trial of 80 RA patients. Participants were assigned to the trial group (40 cases) and the control group (40 cases) by block randomization. The trial group was treated with XFC

three pills each time three times daily for 2 months. The control group was treated with tripterygium glycoside (TPT)

two pills each time three times daily for 2 months. Both groups were followed up after 2 months. The clinical effects

changes in joint and pulmonary function

and quality of life before and after treatment were observed; safety indices were also evaluated. Pain

swelling

tenderness

and duration of morning stiffness of joints were obviously decreased after treatment in both the trial and the control groups compared with baseline (P<0.01). Compared with before treatment

hand grip strength increased significantly after treatment in the trial group (P=0.0000); pulmonary function parameters such as forced expiratory volume in the first second of expiration/forced vital capacity (FEV1/FVC)

50% of the expiratory flow of forced vital capacity (FEF50)

carbon monoxide diffusing capacity (DLco) were increased (P<0.01 or P<0.05); measures of quality of life such as role-physical

body pain

vitality and mental health were also improved after treatment in the trial group (all P<0.05). Joint swelling in the trial group decreased compared with the control group (P=0.0043)

while hand grip strength was increased after treatment (P=0.0000). The increase in FEF50

DLco

and the dimensions of quality of life such as vitality and mental health were all significantly greater in the trial group than the control group (P<0.05 or P<0.01). XFC not only relieved joint pain in RA patients

but also significantly improved the ventilation and diffusion function of the lungs. Therefore

XFC could improve the whole body function and enhance the quality of life of RA patients.

Abstract

To determine the effectiveness and safety of Xinfeng Capsules (新风胶囊

three pills each time three times daily for 2 months. The control group was treated with tripterygium glycoside (TPT)

two pills each time three times daily for 2 months. Both groups were followed up after 2 months. The clinical effects

changes in joint and pulmonary function

and quality of life before and after treatment were observed; safety indices were also evaluated. Pain

swelling

tenderness

and duration of morning stiffness of joints were obviously decreased after treatment in both the trial and the control groups compared with baseline (P<0.01). Compared with before treatment

50% of the expiratory flow of forced vital capacity (FEF50)

carbon monoxide diffusing capacity (DLco) were increased (P<0.01 or P<0.05); measures of quality of life such as role-physical

body pain

vitality and mental health were also improved after treatment in the trial group (all P<0.05). Joint swelling in the trial group decreased compared with the control group (P=0.0043)

while hand grip strength was increased after treatment (P=0.0000). The increase in FEF50

DLco

but also significantly improved the ventilation and diffusion function of the lungs. Therefore

XFC could improve the whole body function and enhance the quality of life of RA patients.

关键词

rheumatoid arthritispulmonary functionquality of lifeXinfeng Capsuleclinical trial

Keywords

rheumatoid arthritispulmonary functionquality of lifeXinfeng Capsuleclinical trial

references

Takeuchi T. Achievement in therapy for rheumatoid arthritis without dysfunctional sequela. Clin Calcium 2012;22:167.

Furukawa H, Oka S, Shimada K, Sugii S, Ohashi J, Matsui T, et al. Association of human leukocyte antigen with interstitial lung disease in rheumatoid arthritis: a protective role for shared epitope. PLoS One 2012;7:e33133.

Uhm DC, Nam ES, Lee HY, Lee EB, Yoon YI, Chai GJ. Health-related quality of life in Korean patients with rheumatoid arthritis: association with pain, disease activity, disability in activities of daily living and depression. J Kor Acad Nurs 2012;42:434–442.

Santi V, Legovi D, Sestan B, Jurdana H, Marinovi M. Measuring improvement following total hip and knee arthroplasty using the SF-36 Health Survey. Coll Antropol 2012;36:207–212.

Wu GL, Li TY, Fan YS, Yu GY. Therapeutic effect of Chinese herbal medicine for strengthening qi, nourishing yin, and removing stasis on serum osteopontin and quality of life of patients with primary Sjogren's syndrome. Chin J Integr Med 2011;17:710–714.

Cao YX, Liu J, Zhu Y. Effect of Xinfeng Capsule on the cardiac function in patients with rheumatoid arthritis. Chin J Integr Med 2011;17:738–743.

Liu J, Liu RL. The potential role of Chinese medicine in ameliorating extra-articular manifestations of rheumatoid arthritis. Chin J Integr Med 2011;17:735–737.

Liu J, Yu XF, Zong RK, Wang Y. Effects Xinfeng Capsule on patients of active rheumatoid arthritis with depression. J Tianjin Tradit Chin Med (Chin) 2008;25:274–276.

Liu J, Yu XF, Zong RK. Effects of Xinfeng Capsule on behaviors and myocardial ultrastructure in adjuvant arthritis rats. J Chin Integr Tradit West Med (Chin) 2008;28:606–610.

Hakala M, Pöllänen R, Nieminen P. The ARA 1987 revised criteria select patients with clinical rheumatoid arthritis from a population based cohort of subjects with chronic rheumatic diseases registered for drug reimbursement. J Rheumatol 1993;20:1674–1678.

Ministry of Health of the People's Republic of China. Clinical guideline of new drugs for traditional Chinese medicine (Trial). Beijing: China Medical Science Press; 1993:91–94.

Bian ZX, Li YP, Moher D, Dangenais S, Liu L, Wu TX, et al. Improving the quality of randomized controlled trials in Chinese herbal medicine. Part I: clinical trial design and methodology. J Chin Integr Med 2006;4:120–129.

Zheng XY. Clinical guideline of new drugs of traditional Chinese medicine. Beijing: Chinese Medicine Science and Technology Publishing House; 2002:64,115,118.

Prevoo ML, van't Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995;38:315–324.

Ware JE, Snow KK, Kosinski M, SF-36 health survey manual and interpretation guide. Boston: Quality Metric Incorporated; 1993:203–205.

Liu CJ, Li NX, Ren XH, Li J, Zhang J, Sun D. Feasibility of using Short Form 36 in Chinese population. J West Chin Univ Med Sci (Chin) 2001;32:39–42.

Li J, Liu CJ, Li NX, He TW, Li BY. Scaling the SF-36 in a Chinese population. J West Chin Univ Med Sci (Chin) 2001;32:36–38, 47.

Chen GZ, Xu YX, Zhang JW, Liu SH, Guo ZY. Effect of acupoint catgut-embedding on the quality of life, reproductive endocrine and bone metabolism of postmenopausal women. Chin J Integr Med 2010;16:498–503.

Yang QY, Lu S, Sun HR. Clinical effect of Astragalus granule of different dosages on quality of life in patients with chronic heart failure. Chin J Integr Med 2011;17:146–149.

Li H, Liu LT, Zhao WM, Liu JG, Yao MJ, Han YX, et al. Effect of traditional and integrative regimens on quality of life and early renal impairment in elderly patients with isolated systolic hypertension. Chin J Integr Med 2010;16:216–221.

Basra MK, Hussain S. Application of the dermatology life quality index in clinical trials of biologics for psoriasis. Chin J Integr Med 2012;18:179–185.

Shen HH, Wang K, Li W, Ying YH, Gao GX, Li XB, et al. Astragalus Membranaceus prevents airway hyperreactivity in mice related to Th2 response inhibition. J Ethnopharmacol 2008;116:363–369.

Wei H, Sun R, Xiao W, Feng J, Zhen C, Xu X, Tian Z. Traditional Chinese medicine Astragalus reverses predominance of Th2 cytokines and their up-stream transcript factors in lung cancer patients. Oncol Rep 2003;10:1507–1512.

Dong JC, Zhao FD, Xie JY. Effects of milkvetch root on neuro-endocrino-immune network in asthma model rat. Chin J Integr Tradit West Integr Med (Chin) 2007;27:619–622.

Yao HT, Lin JH, Chiang MT, Chiang W, Luo MN, Lii CK. Suppressive effect of the ethanolic extract of adlay bran on cytochrome P-450 enzymes in rat liver and lungs. J Agric Food Chem 2011;59:4306–4314.

Hoyle GW, Hoyle CI, Chen J, Chang W, Williams RW, Rando RJ. Identification of triptolide, a natural diterpenoid compound, as an inhibitor of lung inflammation. Am J Physiol Lung Cell Mol Physiol 2010;298:L830–L836.

Chen M, Lv Z, Jiang S. The effects of triptolide on airway remodelling and transforming growth factor-ß1/ Smad signalling pathway in ovalbumin-sensitized mice. Immunology 2011; 32:376–384.

Zhao HM, Zuo ZQ, Cheng SM. Effects of scorpion and centipede on IL-2, IL-4, and IL-10 in the small intestinal mucosa and joint injury of rats with collagen induced arthritis. Chin J Integr Tradit West Integr Med (Chin) 2012;32:80–83.

Ai Q, Zhang JH, Tian G, Yang Y, Li DY, Gao M. Effect of Astragalus implant on actions of mice with chronic unpredictable mild stress depression. J Dalian Med Univ (Chin) 2010;32:405–407.

Ding YP, Ma LM, Li YP. The effect of Astragalus injection on the behavior and SOD activity and MAD content of hippocampus in chronic stress depression rats. J Northwest Normal Univ (Chin) 2011;47(6):75–79.

Lu YL, Wang ML, Yan Y. Coix comprehensive development and utilization. Food Nutri China (Chin) 2013;19:64–66.

An XD, Lin Z, May BH, Lin L, Xu YJ, Xue CL. Oral Chinese herbal medicine for improvement of quality of life in patients with stable chronic obstructive pulmonary disease: a systematic review. J Altern Complement Med 2012;18:731–743.

FULL TEXT LINK

More>

Views

Downloads

CSCD

Alert me when the article has been cited

Submit

Tools

Publicity Resources

The potential role of Chinese medicine in ameliorating extra-articular manifestations of rheumatoid arthritis

Effect of Xinfeng Capsule (新风胶囊) on the cardiac function in patients with rheumatoid arthritis

Clinical trials of integrative medicine for rheumatoid arthritis: Issues and recommendations

Dalitong Granule (达立通颗粒) combined with electroacupuncture in the treatment of functional dyspepsia: A randomized controlled trial

Related Author

No data

Related Institution

Department of Rheumatology, The First Affiliated Hospital of Anhui College of Traditional Chinese Medicine

Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences

Hong Kong Institute for Advancing Translational Medicine in Bone & Joint Diseases, School of Chinese Medicine, Hong Kong Baptist University

Department of Gastroenterology, the First Affiliated Hospital of Xinxiang Medical University, Weihui

Department of Stomatology, the First Affiliated Hospital of Xinxiang Medical University, Weihui

Address：1 Caochang, xiyuan, Beijing, People's Republic of China Postal code：100091
Tel：010-62886827, 62877592 Fax：010-62874291
Technical support is provided by Beijing Founder electronics co., LTD 京ICP备05067934号-1 京公网安备11010802024621
It is recommended to read the content of this site in Chrome&IE9+. Please switch to extreme mode in browser 360.
Cookies We use cookies to help provide and enhance our service and tailor content. By continuing, you agree to the use of cookies.

⁰