Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism

Yue Xing; Ri-bao Wei; Lu Tang; Yue Yang; Xiao-yong Zheng; Zi-cheng Wang; Yu-wei Gao

doi:10.1007/s11655-015-2137-y

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Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism

Updated：2021-08-27

- Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism
- Chinese Journal of Integrative Medicine Vol. 21, Issue 4, Pages: 266-273(2015)
- Affiliations：
  
  1. State Discipline and State Key Laboratory of Kidney Disease (Chinese PLA General Hospital, 2011DAV),Beijing,China,00088
  2. Department of Rheumatism Immunity, Tianjin First Center Hospital,Tianjin,China
- Author bio：
- Funds：
  
  Supported by the National Nature Science Foundation of China (No. 81273968 and No. 81471027), and Ministerial Project of the National Working Commission on Aging (No. QLB2014W002)
- DOI：10.1007/s11655-015-2137-y
  CLC：
- Published：2015，
  
  Published Online：16 April 2015，
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Xing, Y., Wei, Rb., Tang, L. et al. Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism., Chin. J. Integr. Med. 21, 266–273 (2015). https://doi.org/10.1007/s11655-015-2137-y

Yue Xing, Ri-bao Wei, Lu Tang, et al. Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism. [J]. Chinese Journal of Integrative Medicine 21(4):266-273(2015)
Xing, Y., Wei, Rb., Tang, L. et al. Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism., Chin. J. Integr. Med. 21, 266–273 (2015). https://doi.org/10.1007/s11655-015-2137-y DOI：

Yue Xing, Ri-bao Wei, Lu Tang, et al. Protective effect of salidroside on contrast-induced nephropathy in comparison with N-acetylcysteine and its underlying mechanism. [J]. Chinese Journal of Integrative Medicine 21(4):266-273(2015) DOI： 10.1007/s11655-015-2137-y.

摘要

To study the prevention effect of salidroside on contrast-induced-nephropathy (CIN) and its underlying mechanism. A total of 24 Wistar rats were randomly divided into 4 groups with 6 in each group. Rats were firstly administrated with normal saline (control and model groups)

N-acetylcysteine (NAC

NAC group) and salidroside (salidroside group) for 7 days before model establishment in each group

respectively. Histopathological analysis was performed by periodic acid-Schiff (PAS) staining. Oxidative stress related parameters including superoxide dismutase (SOD) and methane dicarboxylic aldehyde (MDA)

nitric oxide (NO)

angiotensin II (Ang II)

8-hydroxy-2′-deoxyguanosine (8-OHdG)

mRNA and protein levels of endothelial nitric oxide synthase (eNOS)

and nitric oxide synthase (NOS) activity were measured. Compared with the control group

the levels of MDA

Ang II and 8-OHdG were all significantly increased and levels of SOD

and eNOS mRNA and protein were decreased significantly in the model group (P<0.05). Meanwhile

the NOS activity was also significantly decreased in the model group (P<0.05). In addition

the levels of these parameters were all improved in the NAC (P<0.05) and salidroside groups and no significant different was found between these two groups (P>0.05). Salidroside can be the potential substitute of NAC to prevent CIN. The underlying mechanism may be associated with oxidative stress damage caused by contrast agents.

Abstract

N-acetylcysteine (NAC

NAC group) and salidroside (salidroside group) for 7 days before model establishment in each group

nitric oxide (NO)

angiotensin II (Ang II)

8-hydroxy-2′-deoxyguanosine (8-OHdG)

mRNA and protein levels of endothelial nitric oxide synthase (eNOS)

and nitric oxide synthase (NOS) activity were measured. Compared with the control group

the levels of MDA

Ang II and 8-OHdG were all significantly increased and levels of SOD

and eNOS mRNA and protein were decreased significantly in the model group (P<0.05). Meanwhile

the NOS activity was also significantly decreased in the model group (P<0.05). In addition

关键词

salidrosidecontrast-induced-nephropathyoxidative stressN-acetylcysteineChinese Medicine

Keywords

salidrosidecontrast-induced-nephropathyoxidative stressN-acetylcysteineChinese Medicine

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