Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

Hyun Jun Park; Sangmin Choe; Nam Cheol Park

doi:10.1007/s11655-015-2139-9

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Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study

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- Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study
- Chinese Journal of Integrative Medicine Vol. 22, Issue 7, Pages: 490-495(2016)
- Affiliations：
  
  1. Department of Urology, Pusan National University School of Medicine, Busan, Republic of Korea
  2. Medical Research Institute of Pusan National University Hospital, Busan, Republic of Korea
  3. Division of Clinical Pharmacology, Clinical Trial Center, Pusan National University Hospital, Busan, Republic of Korea
- Author bio：
- Funds：
  
  Supported by a 2010 grant from the Korean Society for Ginseng funded by the Korean Ginseng Corporation, Republic of Korea
- DOI：10.1007/s11655-015-2139-9
  CLC：
- Published：2016，
  
  Published Online：12 May 2015，
Scan for full text
Park, H.J., Choe, S. & Park, N.C. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study., Chin. J. Integr. Med. 22, 490–495 (2016). https://doi.org/10.1007/s11655-015-2139-9

Hyun Jun Park, Sangmin Choe, Nam Cheol Park. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study. [J]. Chinese Journal of Integrative Medicine 22(7):490-495(2016)
Park, H.J., Choe, S. & Park, N.C. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study., Chin. J. Integr. Med. 22, 490–495 (2016). https://doi.org/10.1007/s11655-015-2139-9 DOI：

Hyun Jun Park, Sangmin Choe, Nam Cheol Park. Effects of Korean red ginseng on semen parameters in male infertility patients: A randomized, placebo-controlled, double-blind clinical study. [J]. Chinese Journal of Integrative Medicine 22(7):490-495(2016) DOI： 10.1007/s11655-015-2139-9.

摘要

To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized

double-blind

placebo-controlled study. A total of 80 male infertility patients with varicocele were recruited from April 2011 to February 2012. The subjects were then divided into the following four groups: non-varicocelectomy (V)+placebo (P) group

V+P group

non-V+KRG group (1.5-g KRG daily)

and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. All groups but not the non-V+P group

showed significant improvements in sperm concentrations

motility

morphology

and viability at the end of the study. However

there were no significant differences in serum follicle-stimulating hormone

luteinizing hormone

and testosterone among groups. The incidence of adverse events was low

and all events were assumed to be unrelated to the treatments administered. Although the exact mechanism by which KRG improves spermatogenesis remains unclear

KRG may be a useful agent for the treatment of male infertility. Nevertheless

additional studies to evaluate the optimal dose and duration of treatment are needed.

Abstract

To investigate the effects of Korean red ginseng (KRG) on semen parameters in male infertility patients in a randomized

double-blind

V+P group

non-V+KRG group (1.5-g KRG daily)

and V+KGR group (1.5-g KRG daily). Semen analysis was performed and hormonal levels were measured in each treatment arm after 12 weeks. All groups but not the non-V+P group

showed significant improvements in sperm concentrations

motility

morphology

and viability at the end of the study. However

there were no significant differences in serum follicle-stimulating hormone

luteinizing hormone

and testosterone among groups. The incidence of adverse events was low

and all events were assumed to be unrelated to the treatments administered. Although the exact mechanism by which KRG improves spermatogenesis remains unclear

KRG may be a useful agent for the treatment of male infertility. Nevertheless

additional studies to evaluate the optimal dose and duration of treatment are needed.

关键词

Panax GinsengMale Infertilityspermatogenesis

Keywords

Panax GinsengMale Infertilityspermatogenesis

references

Kamischke A, Nieschlag E. Analysis of medical treatment of male infertility. Hum Reprod 1999;14 Suppl 1:1–23.

Lombardo F, Sansone A, Romanelli F, Paoli D, Gandini L, Lenzi A. The role of antioxidant therapy in the treatment of male infertility: an overview. Asian J Androl 2011;13:690–697.

Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567–575.

Bahrke MS, Morgan WR. Evaluation of the ergogenic properties of ginseng: an update. Sports Med 2000;29:113–133.

Cho YK, Sung H, Lee HJ, Joo CH, Cho GJ. Long-term intake of Korean red ginseng in HIV-1-infected patients: development of resistance mutation to zidovudine is delayed. Int Immunopharmacol 2001;1:1295–1305.

Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A doubleblind crossover study evaluating the efficacy of Korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070–2073.

Park JS, Hwang SY, Lee WS, Yu KW, Paek KY, Hwang BY, et al. The therapeutic effect of tissue cultured root of wild Panax ginseng C.A. Mayer on spermatogenetic disorder. Arch Pharm Res 2006;29:800–807.

Hwang SY, Kim WJ, Wee JJ, Choi JS, Kim SK. Panax ginseng improves survival and sperm quality in guinea pigs exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. BJU Int 2004;94:663–668.

Tsai SC, Chiao YC, Lu CC, Wang PS. Stimulation of the secretion of luteinizing hormone by ginsenoside-Rb1 in male rats. Chin J Physiol 2003;46:1–7.

Chen JC, Chen LD, Tsauer W, Tsai CC, Chen BC, Chen YJ. Effects of ginsenoside Rb2 and Rc on inferior human sperm motility in vitro. Am J Chin Med 2001;29:155–160.

Zhang H, Zhou Q, Li X, Zhao W, Wang Y, Liu H, et al. Ginsenoside Re promotes human sperm capacitation through nitric oxide-dependent pathway. Mol Reprod Dev 2007;74:497–501.

Salvati G, Genovesi G, Marcellini L, Paolini P, De Nuccio I, Pepe M, et al. Effects of Panax ginseng C.A. Meyer saponins on male fertility. Panminerva Med 1996;38:249–254.

Takihara H, Sakatoku J, Cockett AT. The pathophysiology of varicocele in male infertility. Fertil Steril 1991;55:861–868.

Lyon RP, Marshall S, Scott MP. Varicocele in childhood and adolescence: implication in adulthood infertility? Urology 1982;19:641–644.

World Health Organization, Department of Reproductive Health and Research. WHO laboratory manual for the examination and processing of human semen. 2010. Available at: http://www.who.int/reproductivehealth/publications/infertility/9789241547789/en/ index.html. Accessed January 20, 2014.

Nieschlag E, Lenzi A. The conventional management of male infertility. Int J Gynaecol Obstet 2013;123 Suppl 2:S31–35.

Park WS, Shin DY, Kim do R, Yang WM, Chang MS, Park SK. Korean ginseng induces spermatogenesis in rats through the activation of cAMP-responsive element modulator (CREM). Fertil Steril 2007;88:1000–1002.

Yang WM, Park SY, Kim HM, Park EH, Park SK, Chang MS. Effects of Panax ginseng on glial cellderived neurotrophic factor (GDNF) expression and spermatogenesis in rats. Phytother Res 2011;25:308–311.

Kim IH, Kim SK, Kim EH, Kim SW, Sohn SH, Lee SC, et al. Korean red ginseng up-regulates C21-steroid hormone metabolism via Cyp11a1 gene in senescent rat Testes. J Ginseng Res 2011;35:272–282.

Jang M, Min JW, In JG, Yang DC. Effects of red ginseng extract on the epididymal sperm motility of mice exposed to ethanol. Int J Toxicol 2011;30:435–442.

Agarwal A, Hamada A, Esteves SC. Insight into oxidative stress in varicocele-associated male infertility: part 1. Nat Rev Urol 2012;9:678–690.

Bae HM, Kim SS, Cho CW, Yang DC, Ko SK, Kim KT. Antioxidant activities of ginseng seeds treated by autoclaving. J Ginseng Res 2012;36:411–417.

Ryu JK, Lee T, Kim DJ, Park IS, Yoon SM, Lee HS, et al. Free radical-scavenging activity of Korean red ginseng for erectile dysfunction in non-insulin-dependent diabetes mellitus rats. Urology 2005;65:611–615.

Kim MK, Lee JW, Lee KY, Yang DC. Microbial conversion of major ginsenoside Rb(1) to pharmaceutically active minor ginsenoside Rd. J Microbiol 2005;43:456–462.

Christensen LP, Jensen M. Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds. J Nat Med 2009;63:159–168.

Choi J, Kim TH, Choi TY, Lee MS. Ginseng for health care: a systematic review of randomized controlled trials in Korean literature. PLoS One 2013;8:e59978.

Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol 2008;66:444–450.

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