Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats

Fan Pan; Tian-yuan Yu; Steven Wong; Si-tong Xian; Meng-qian Lu; Jian-cong Wu; Yu-feng Gao; Xiao-qin Li; Nan Geng; Bin-bin Yao

doi:10.1007/s11655-015-2142-1

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Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats

Updated：2021-08-27

- Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats
- Chinese Journal of Integrative Medicine Vol. 23, Issue 8, Pages: 617-624(2017)
- Affiliations：
  
  1. Collage of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine,Beijing,China
  2. The 2nd Massage Department, Beijing Massage Hospital,Beijing,China
  3. Department of Encephalopathy of Mogol Medicine, Affiliated Hospital of Inner Mongolia University for the Nationalities, Tongliao, Inner Mongolia Autonomous Region,China
  4. Department of Acupuncture and Moxibustion, Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang,China
  5. Department of Massage Physiotherapy, Beijing University of Chinese Medicine Dongfang Hospital,Beijing,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81373759), Research Fund for the Doctoral Program of Higher Education (No. 20130013110016), Natural Science Foundation of Beijing (No. 7142097)
- DOI：10.1007/s11655-015-2142-1
  CLC：
- Published：2017，
  
  Published Online：13 May 2015，
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Pan, F., Yu, Ty., Wong, S. et al. Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats., Chin. J. Integr. Med. 23, 617–624 (2017). https://doi.org/10.1007/s11655-015-2142-1

Fan Pan, Tian-yuan Yu, Steven Wong, et al. Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats. [J]. Chinese Journal of Integrative Medicine 23(8):617-624(2017)
Pan, F., Yu, Ty., Wong, S. et al. Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats., Chin. J. Integr. Med. 23, 617–624 (2017). https://doi.org/10.1007/s11655-015-2142-1 DOI：

Fan Pan, Tian-yuan Yu, Steven Wong, et al. Chinese tuina downregulates the elevated levels of tissue plasminogen activator in sciatic nerve injured Sprague-Dawley rats. [J]. Chinese Journal of Integrative Medicine 23(8):617-624(2017) DOI： 10.1007/s11655-015-2142-1.

摘要

To elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury

and to detect the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)

which is thought to play an important role in nerve regeneration. Thirty-two adult male Sprague-Dawley rats were subjected to sciatic nerve crush injury and 16 rats (sham-operated group) went through a sham operation. Control group was given no treatment while tuina group received tuina therapy since day 7 post-surgery. Tuina treatment was performed once a day and lasted for 20 days. The sciatic functional index was examined every 5 days during the treatment session. The rats’ gastrocnemius muscles were evaluated for changes in mass and immunohistochemistry techniques were performed to detect the levels of tPA and PAI-1. Tuina therapy improved the motor function of sciatic nerve injured rats (P<0.05)

however

it did not increase muscle volume (P<0.05). Tuina downregulated the levels of tPA and PAI-1 (P<0.05). The present study implies that tuina treatment could accelerate rehabilitation of peripheral nerve injury.

Abstract

To elucidate the mechanism of Chinese tuina in treating sciatic nerve crush injury

and to detect the levels of tissue plasminogen activator (tPA) and plasminogen activator inhibitor-1 (PAI-1)

however

关键词

Chinese Medicinephysical therapyperipheral neuropathymassage

Keywords

Chinese Medicinephysical therapyperipheral neuropathymassage

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