Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials

Chen-xia Sheng; Ze-qi Chen; Han-jin Cui; A-li Yang; Cong Wang; Zhe Wang; Nan-xiang Su; Tao Tang

doi:10.1007/s11655-015-2287-y

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Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials

Updated：2021-08-27

- Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials
- Chinese Journal of Integrative Medicine Vol. 23, Issue 5, Pages: 386-395(2017)
- Affiliations：
  
  1. Institute of Integrative Medicine, Xiangya Hospital, Central South University,Changsha,China
  2. Department of Traditional Chinese Medicine, The Second Xiangya Hospital, Central South University,Changsha,China
  3. Key Laboratory of Chinese Gan of State Administration of Traditional Chinese Medicine of China,Changsha,China
- Author bio：
- Funds：
  
  Supported by the Natural Science Foundation of Hunan Proince (No. 14JJ2024) and Traditional Chinese Medicine Science Research Foundation of Health Department of Hunan Province, China (No. 201346)
- DOI：10.1007/s11655-015-2287-y
  CLC：
- Published：2017，
  
  Published Online：10 October 2015，
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Sheng, Cx., Chen, Zq., Cui, Hj. et al. Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 23, 386–395 (2017). https://doi.org/10.1007/s11655-015-2287-y

Chen-xia Sheng, Ze-qi Chen, Han-jin Cui, et al. Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 23(5):386-395(2017)
Sheng, Cx., Chen, Zq., Cui, Hj. et al. Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials., Chin. J. Integr. Med. 23, 386–395 (2017). https://doi.org/10.1007/s11655-015-2287-y DOI：

Chen-xia Sheng, Ze-qi Chen, Han-jin Cui, et al. Is the Chinese medicinal formula Guipi Decoction (归脾汤) effective as an adjunctive treatment for depression? A meta-analysis of randomized controlled trials. [J]. Chinese Journal of Integrative Medicine 23(5):386-395(2017) DOI： 10.1007/s11655-015-2287-y.

摘要

To evaluate the effectiveness and safety of Guipi Decoction (归脾汤

GPD) as an adjunctive in the treatment of depression. A review of all relevant studies retrieved from a search of the following databases were conducted without any language restriction: Excerpt Medica Database (EMBASE)

PubMed

Cochrane Central Register of Controlled Trials

China National Knowledge Infrastructure (CNKI)

VIP Information

Wanfang Data

and the Chinese Biomedical Literature Database. Papers published until February 2013 were taken into consideration. The analysis was performed using the Cochrane software Revman 5.1. Nine randomized controlled trials involving 620 patients with depression were included in this review. The meta-analysis revealed that compared with antidepressant therapy alone

treatment with a combination of GPD and an antidepressant drug signifificantly improved the symptoms of depression [weighted mean difference (WMD):–3.09; 95% confifidence interval (CI):–4.11 to–2.07] and increased the rates of effectiveness (OR: 4.75; 95% CI: 2.66–8.51) as well as recovery (OR: 1.73; 95% CI: 1.17–2.56). The adverse effects of GPD were not found to be signifificant in these studies. The fifindings of this meta-analysis were in keeping with the notion that GPD formulations were effective in the treatment of depression without causing any serious adverse effects. However

currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression.

Abstract

To evaluate the effectiveness and safety of Guipi Decoction (归脾汤

PubMed

Cochrane Central Register of Controlled Trials

China National Knowledge Infrastructure (CNKI)

VIP Information

Wanfang Data

currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression.

关键词

Guipi Decoctiondepressionmeta-analysisChinese medicine formula

Keywords

Guipi Decoctiondepressionmeta-analysisChinese medicine formula

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