Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats

Yuan Guo; Dong-yuan Cao; Zhang-jin Zhang; Fan-rong Yao; Hui-sheng Wang; Yan Zhao

doi:10.1007/s11655-015-2300-5

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Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats

Updated：2021-08-27

- Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats
- Chinese Journal of Integrative Medicine Vol. 22, Issue 7, Pages: 537-544(2016)
- Affiliations：
  
  1. Department of Physiology and Pathophysiology, School of Basal Medical Science, Xi’an Jiaotong University Health Science Center,Xi’an,China
  2. Research Center for Stomatology, Stomatological Hospital, Xi’an Jiaotong University Health Science Center,Xi’an,China
  3. School of Chinese Medicine, The University of Hong Kong,Hong Kong SAR,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81200604)
- DOI：10.1007/s11655-015-2300-5
  CLC：
- Published：2016，
  
  Published Online：2 December 2015，
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Guo, Y., Cao, Dy., Zhang, Zj. et al. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats., Chin. J. Integr. Med. 22, 537–544 (2016). https://doi.org/10.1007/s11655-015-2300-5

Yuan Guo, Dong-yuan Cao, Zhang-jin Zhang, et al. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats. [J]. Chinese Journal of Integrative Medicine 22(7):537-544(2016)
Guo, Y., Cao, Dy., Zhang, Zj. et al. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats., Chin. J. Integr. Med. 22, 537–544 (2016). https://doi.org/10.1007/s11655-015-2300-5 DOI：

Yuan Guo, Dong-yuan Cao, Zhang-jin Zhang, et al. Electrical signal propagated across acupoints along Foot Taiyang Bladder Meridian in rats. [J]. Chinese Journal of Integrative Medicine 22(7):537-544(2016) DOI： 10.1007/s11655-015-2300-5.

摘要

To investigate the electrical signals propagated along Foot Taiyang Bladder Meridian (BL) in a rat model. The experiments were performed on Dark-Agouti (DA)

DA.1U and Sprague Dawley (SD) rats. The antidromic electrical stimulation was applied on the nerve innervating "Pishu" (BL 20) to mimic the acupoint electro-acupuncture (EA). The activities recording from adjacent nerve innervating acupoint "Danshu" (BL 19) or "Weishu" (BL 21) were recorded as indics for acupoint

including the mechanical threshold and discharge rate. After mimic EA on BL 20

C and Aδ units from adjacent BL 19 or BL 21 were sensitized including the decrease in mechanical threshold and increase in discharge rates in DA

DA.1U and SD rats

especially in DA rats. The average discharge rate increased from 2.40±0.26 to 6.06±0.55 and from 1.92±0.42 to 6.17±1.10 impulse/min (P<0.01)

and the mechanical threshold decreased from 0.52±0.12 to 0.24±0.05 and from 0.27±0.02 to 0.16±0.01 mmol/L (P<0.01) in C (n=15) and Aδ (n=18) units in DA rats. The net change in discharge rates from C units were 152.5%

144.7% and 42.4% in DA

DA.1U and SD rats

respectively

among which DA rat’s was the highest (P<0.05). In Aδ units

the net change in DA rats were also the highest (221.5%

139.2% and 49.2% in DA

DA.1U and SD rats). These results showed that mimic acupoint EA activated adjacent acupoints along BL in three rat strains

which might be related to propagated sensation along meridians (PSM). In addition

DA rats were more sensitive and might be a good model animal for PSM research.

Abstract

To investigate the electrical signals propagated along Foot Taiyang Bladder Meridian (BL) in a rat model. The experiments were performed on Dark-Agouti (DA)

including the mechanical threshold and discharge rate. After mimic EA on BL 20

C and Aδ units from adjacent BL 19 or BL 21 were sensitized including the decrease in mechanical threshold and increase in discharge rates in DA

DA.1U and SD rats

especially in DA rats. The average discharge rate increased from 2.40±0.26 to 6.06±0.55 and from 1.92±0.42 to 6.17±1.10 impulse/min (P<0.01)

144.7% and 42.4% in DA

DA.1U and SD rats

respectively

among which DA rat’s was the highest (P<0.05). In Aδ units

the net change in DA rats were also the highest (221.5%

139.2% and 49.2% in DA

DA.1U and SD rats). These results showed that mimic acupoint EA activated adjacent acupoints along BL in three rat strains

which might be related to propagated sensation along meridians (PSM). In addition

DA rats were more sensitive and might be a good model animal for PSM research.

关键词

propagated sensation along meridianselectro-acupunctureFoot Taiyang Bladder Meridiannerve innervating acupointacupuncture

Keywords

propagated sensation along meridianselectro-acupunctureFoot Taiyang Bladder Meridiannerve innervating acupointacupuncture

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Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University

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Department of Traditional Chinese Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences

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