Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice

Jian-ping Shi; Shui-xiu Li; Zheng-lai Ma; Ai-li Gao; Yan-jun Song; Hong Zhang

doi:10.1007/s11655-015-2303-2

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Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice

Updated：2021-08-27

- Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice
- Chinese Journal of Integrative Medicine Vol. 22, Issue 12, Pages: 925-931(2016)
- Affiliations：
  
  1. Department of Dermatology First Affiliated Hospital and Institute of Mycology, Jinan University,Guangzhou,China
  2. Department of Dermatology Shenzhen Shajing Affiliated Hospital of Guangzhou Medical University,Guangdong Province,Shenzhen,China
  3. Department of Histology and Embryology, Key Laboratory for Regenerative Medicine of the Ministry of Education, Institute of Fetal-Preterm Labor Medicine, Medical College of Jinan University,Guangzhou,China
  4. Guangzhou Institute of Dermstology,Guangzhou,China
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation of China (No. 81171542 and Na 81471995)
- DOI：10.1007/s11655-015-2303-2
  CLC：
- Published：2016，
  
  Published Online：29 October 2015，
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Shi, Jp., Li, Sx., Ma, Zl. et al. Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice., Chin. J. Integr. Med. 22, 925–931 (2016). https://doi.org/10.1007/s11655-015-2303-2

Jian-ping Shi, Shui-xiu Li, Zheng-lai Ma, et al. Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice. [J]. Chinese Journal of Integrative Medicine 22(12):925-931(2016)
Shi, Jp., Li, Sx., Ma, Zl. et al. Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice., Chin. J. Integr. Med. 22, 925–931 (2016). https://doi.org/10.1007/s11655-015-2303-2 DOI：

Jian-ping Shi, Shui-xiu Li, Zheng-lai Ma, et al. Acute and sub-chronic toxicity of tetrandrine in intravenously exposed female BALB/c mice. [J]. Chinese Journal of Integrative Medicine 22(12):925-931(2016) DOI： 10.1007/s11655-015-2303-2.

摘要

To evaluate the acute and sub-chronic toxicity of intravenously administered tetrandrine (TET) in female BALB/c mice. The median lethal dose (LD50) of intravenously administered TET was calculated in mice using Dixon's up-and-down method. In the acute toxicity study

mice were intravenously administered with TET at a single dose of 20

100

180

260 and 340 mg/kg

respectively and were evaluated at 14 days after administration. In the sub-acute toxicity study

mice were intravenously administered various doses of TET (30

90 and 150 mg/kg) each day for 14 consecutive days. Clinical symptoms

mortality

body weight

serum biochemistry

organ weight and histopathology were examined at the end of the experiment

as well as after a 1-week recovery period. LD50 was found to be 444.67±35.76 mg/kg. In the acute toxicity study

no statistically signifificant differences in body weight

blood biochemistry

or organ histology were observed between the administration and control groups when mice were intravenously administered with single dose at 20

100

180

260 and 340 mg/kg of TET (P >0.05). In the sub-acute toxicity study

no signifificant changes in body weight

biochemistry and organ histology were observed with up to 90 mg/kg of TET compared with the control group (P >0.05)

however

in the 150 mg/kg administered group

TET induced transient toxicity to liver

lungs and kidneys

but withdrawal of TET can lead to reversal of the pathological conditions. The overall fifindings of this study indicate that TET is relatively non-toxic from a single dose of 20

100

180

260 or 340 mg/kg

and that up to 90 mg/kg daily for 14 consecutive days can be considered a safe application dose.

Abstract

mice were intravenously administered with TET at a single dose of 20

100

180

260 and 340 mg/kg

respectively and were evaluated at 14 days after administration. In the sub-acute toxicity study

mice were intravenously administered various doses of TET (30

90 and 150 mg/kg) each day for 14 consecutive days. Clinical symptoms

mortality

body weight

serum biochemistry

organ weight and histopathology were examined at the end of the experiment

as well as after a 1-week recovery period. LD50 was found to be 444.67±35.76 mg/kg. In the acute toxicity study

no statistically signifificant differences in body weight

blood biochemistry

or organ histology were observed between the administration and control groups when mice were intravenously administered with single dose at 20

100

180

260 and 340 mg/kg of TET (P >0.05). In the sub-acute toxicity study

no signifificant changes in body weight

biochemistry and organ histology were observed with up to 90 mg/kg of TET compared with the control group (P >0.05)

however

in the 150 mg/kg administered group

TET induced transient toxicity to liver

lungs and kidneys

but withdrawal of TET can lead to reversal of the pathological conditions. The overall fifindings of this study indicate that TET is relatively non-toxic from a single dose of 20

100

180

260 or 340 mg/kg

and that up to 90 mg/kg daily for 14 consecutive days can be considered a safe application dose.

关键词

Tetrandrinefemale BALB/c miceacute and sub-chronic toxicityChinese Medicine

Keywords

Tetrandrinefemale BALB/c miceacute and sub-chronic toxicityChinese Medicine

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