Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis

Qian-qian Liang; Qi Shi; Ronald W. Wood; Lian-ping Xing; Yong-jun Wang

doi:10.1007/s11655-015-2305-0

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Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis

Updated：2021-08-27

- Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis
- Chinese Journal of Integrative Medicine Vol. 21, Issue 9, Pages: 648-655(2015)
- Affiliations：
  
  1. Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine,Shanghai,China
  2. Department of Obstetrics and Gynecology, Urology, and Neurobiology and Anatomy, University of Rochester Medical Center,Rochester,USA
  3. Department of Pathology and Laboratory Medicine, University of Rochester Medical Center,Rochester,USA
  4. Center for Musculoskeletal Research, University of Rochester Medical Center,Rochester,USA
- Author bio：
- Funds：
  
  Supported by the National Natural Science Foundation, China (No. 81403417, No. 81330085 and No. 81220108027);Special Funding for the National Outstanding Doctoral Dissertation, China (No. 201276);National Institutes of Health, USA (No. AR048697 and No. AR063650);the Lymphatic Malformation Institute, USA;Ministry of Education, Innovative Research Team, China (No. IRT1270);and Shanghai University of Traditional Chinese Medicine, China (085 Project, No. 085ZY1204)
- DOI：10.1007/s11655-015-2305-0
  CLC：
- Published：2015，
  
  Published Online：3 October 2015，
Scan for full text
Liang, Qq., Shi, Q., Wood, R.W. et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis., Chin. J. Integr. Med. 21, 648–655 (2015). https://doi.org/10.1007/s11655-015-2305-0

Qian-qian Liang, Qi Shi, Ronald W. Wood, et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis. [J]. Chinese Journal of Integrative Medicine 21(9):648-655(2015)
Liang, Qq., Shi, Q., Wood, R.W. et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis., Chin. J. Integr. Med. 21, 648–655 (2015). https://doi.org/10.1007/s11655-015-2305-0 DOI：

Qian-qian Liang, Qi Shi, Ronald W. Wood, et al. Peri-articular lymphatic system and "Bi" theory of Chinese medicine in the pathogenesis and treatment of arthritis. [J]. Chinese Journal of Integrative Medicine 21(9):648-655(2015) DOI： 10.1007/s11655-015-2305-0.

摘要

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases

and they have characterization of synovial inflammation and cartilage destruction

associated with the accumulation of numerous catabolic mediators and inflammatory cells in the synovial space and surrounding soft tissues. How these factors are cleared and if the "clearance" process contributes to pathogenesis of arthritis are not known. Recently

we found the existence of the peri-articular lymphatic system in mouse joints. The blockade of lymphangiogenesis and lymphatic draining function accelerates while stimulation of lymphatic function attenuates the severity of joint tissue lesions in mouse models of RA and OA. More importantly

we noticed the similarity between the dysfunction of lymphatic drainage in arthritic joints and "Bi" theory of Chinese medicine (CM)

and demonstrated that several Bi disease-treated herbal drugs directly affect the function of lymphatic endothelial cells. Here we review the advances about the interactions between joint inflammation and changes in the peri-articular lymphatic system and discuss our view of linking "Bi" theory of CM to lymphatic dysfunction in arthritis.

Abstract

Rheumatoid arthritis (RA) and osteoarthritis (OA) are the two most common joint diseases

and they have characterization of synovial inflammation and cartilage destruction

we noticed the similarity between the dysfunction of lymphatic drainage in arthritic joints and "Bi" theory of Chinese medicine (CM)

关键词

rheumatoid arthritisosteoarthritislymphatic systemBi diseaseChinese Medicine

Keywords

rheumatoid arthritisosteoarthritislymphatic systemBi diseaseChinese Medicine

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